N/A N=420 The CDR Implementation Trial
Pediatric Abusive Head Trauma
Primary: The Number of Higher Risk Patients Evaluated Thoroughly for Abuse at Intervention vs. Control Sites — 128; 128 Participants — p=0.11
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=116 Pediatric Guideline Adherence and Outcomes- Argentina
TBI (Traumatic Brain Injury)
Primary: First 3-day Cumulative Intensive Care Unit (ICU) Traumatic Brain Injury (TBI) Guideline Adherence Rate, Overall — 81.7; 81.0; 83.7; 84.4 mean percentage of guideline…
N/A N=73 Rapid MRI for Acute Pediatric Head Trauma
Head Trauma · Image, Body
Primary: Sensitivity: Percentage of MRIs Correctly Identifying Clinically Important Intracranial Injury (True Positives) — 70 Percentage of MRIs correctly identifying
N/A N=120 Neurocognitive Evaluation of Mild Traumatic Brain Injury in the Hospitalized Pediatric Population
Mild Traumatic Brain Injury · Concussion
Primary: The Feasibility of Inpatient Bedside Neurocognitive Testing of Pediatric Patients With Minor Traumatic Brain Injury. — 120 participants
N/A N=971 Shared Decision Making in Parents of Children With Head Trauma: Head CT Choice
Head Injury
Primary: Assess Parents' Knowledge Regarding Their Child's Risk for a Significant Brain Injury — 6.2; 5.26 Number of questions correct out of 10
N/A N=3,063 Predicting Persistent Postconcussive Problems in Pediatrics (5P)
Concussions · PCS
Primary: Count of Children Who Have Persistent Post-concussive Symptoms (PCS) at One-month Follow-up. — 510; 291 Participants
N/A N=22,430 Development and Testing of a Pediatric Cervical Spine Injury Risk Assessment Tool
Cervical Spine Injury
Primary: Cervical Spine Injury — 274; 159 Participants — p=.05
N/A N=329 Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Pediatric Patients-THAPCA-IH [In Hospital] Trial
Cardiac Arrest
Primary: Survival With Good Neurobehavioral Outcome — 48; 48; 85; 76 Participants — p=0.63
Phase 3 N=295 Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Pediatric Patients-THAPCA-OH [Out of Hospital] Trial
Cardiac Arrest
Primary: Survival With Good Neurobehavioral Outcome — 27; 15; 111; 107 Participants — p=0.14
Phase 4 N=5 Management of Acute Pulmonary Hypertensive Crisis in Children With Known Pulmonary Arterial Hypertension
Pulmonary Arterial Hypertension
Primary: Change in Systemic Vascular Resistance Index (SVRI) to Pulmonary Vascular Resistance Index (PVRI) Ratio (Rp:Rs Ratio) — 0.8; 0.75; 0.61; 0.73 Rp:Rs ratio — p=0.9
N/A N=17 Pediatric Aggression and Violence
Pediatric Aggression and Violence
Primary: Salivary Hormone Correlation With Brief Rating of Aggression by Children and Adolescent (BRACHA) Score — 0.8; 0.4; 0.3; 0.4 ul/dL
N/A N=32 Improving Family-Centered Pediatric Trauma Care: The Standard of Care Versus the Virtual Pediatric Trauma Center
Trauma · Injuries
Primary: Consumer Assessment of Healthcare Providers and Systems Child Hospital Survey Communication Subscale — 0.769; 0.775; 0.735; 0.747 score on a scale
Phase 3 N=523 PreHospital Air Medical Plasma Trial
Hemmorhagic Shock During Air Medical Transport
Primary: Our Primary Outcome for the Proposal Will be 30 Day Mortality — 53; 89 Participants
Phase 3 N=85 Stepped Preventive Care to Reduce the Impact of Acute Pediatric Injury
Stress Disorders, Posttraumatic
Primary: PTSD Symptoms in Children 6 Weeks Post-injury — 12.6; 13.6 Units on a scale — p=.69
N/A N=14 VR Cognitive Rehabiliation for Pediatric TBI
TBI (Traumatic Brain Injury)
Primary: VR-based EF Assessment Task — 1.41; 1.53; 1.71; 1.82 Z-Score
Phase 3 N=500 High-dose Erythropoietin for Asphyxia and Encephalopathy
Neonatal Encephalopathy · Birth Asphyxia
Primary: Number of Participants With Death or Neurodevelopmental Impairment — 126; 110 Participants
N/A N=80 Use of Ibuprofen and Acetaminophen for Treatment of Acute Headache Post Concussion in Children
Concussion · Headache
Primary: Number of Headache Days — 4; 3; 3; 4 number of headache days
N/A N=27 VR-based EF Rehabilitation for Pediatric TBI
Traumatic Brain Injury
Primary: Level of Simulator Sickness [Feasibility and Safety] — 0.16; 0.03 score on a scale
Phase 4 N=26 Methylphenidate for Attention Problems After Pediatric TBI
Traumatic Brain Injury · TBI · ADHD
Primary: Parent Outcome-Vanderbilt ADHD Parent Rating Scales (VADPRS) — 1.10; 1.47; .84; 1.14 units on a scale
N/A N=11 Premie Pouch to Manage Deformational Plagiocephaly in Very Low Birth Weight Infants
Plagiocephaly
Primary: Safety of Use of the Premie Pouch in VLBW Infants — 0 participants
Phase 3 N=1 CEUS Evaluation of Hypoxic Ischemic Injury
Hypoxic-Ischemic Encephalopathy · Brain Ischemia Hypoxia
Primary: Detection of Brain Perfusion Abnormalities Using Contrast-enhanced Ultrasound — 1; 0 Participants
Phase 3 N=256 Safety and Efficacy of Hypothermia to Treat Neonatal Hypoxic-Ischemic Encephalopathy
Hypoxic-Ischemic Encephalopathy
Primary: Death — 27; 22 participants
Phase 2 N=44 Hypertonic Saline as Therapy for Pediatric Concussion
Pain
Primary: Change in Pain — 1.14; 3.5 units on a scale
Phase 1 N=6 A Safety Study of the Auditory Brainstem Implant for Pediatric Profoundly Deaf Patients
Profound Bilateral Deafness Due to · Bilateral Cochlear Aplasia · Bilateral Cochlear Nerve Deficiency
Primary: Primary Endpoint — 6 Participants
N/A N=624 Determining Prevalence of Acute Bilirubin Encephalopathy in Developing Countries
Hyperbilirubinemic Encephalopathy
Primary: Bilirubin Induced Neurologic Dysfunction II Score (BIND II) — 1 units on a scale
Phase 2 N=18 Hyperbaric Treatment of Traumatic Brain Injury (TBI)
Traumatic Brain Injury
Primary: Number of Participants With Improved Cerebral Perfusion — 8 Participants
Phase 2 N=50 Neonatal Erythropoietin And Therapeutic Hypothermia Outcomes in Newborn Brain Injury (NEATO)
Hypoxic-ischemic Encephalopathy · Neonatal Encephalopathy · Birth Asphyxia
Primary: Markers of Organ Function — 10; 6; 9; 12 participants
N/A N=63 Prospective Research in Infants With Mild Encephalopathy
Hypoxic-Ischemic Encephalopathy · Brain Injury · Neonatal Seizure
Primary: Percentage of Infants With Evidence of Neurological Dysfunction, Brain Injury and/or Abnormality. — 28 Participants
N/A N=77 Brain Imaging and Developmental Follow up of Infants Treated With Erythropoietin
Prematurity
Primary: Full Scale IQ, Performance IQ, Verbal IQ, Executive Function — 79; 91; 103; 83 standardized score on a scale
N/A N=14 Measuring Head Control Change With 2D Video Analysis After Utilization of Headpod in Children With Poor Head Control
To Determine Efficacy of the Headpod · Cerebral Palsy
Primary: Change in Head Holding Active Time From Baseline to 6 Months — 83.63 Seconds