Phase 2 N=21 Metoclopramide for Post-Traumatic Headache. A Pilot Study
Post-Traumatic Headache
Primary: Number of Participants With Sustained Headache Relief — 12 Participants
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Phase 3 N=160 Metoclopramide for Post Traumatic Headache
Post-Traumatic Headache
Primary: 0-10 Pain Scale on Which 0 = no Pain and 10= the Worst Pain Imaginable — 5.2; 3.8 units on a scale
Phase 2 N=40 Sumatriptan as Treatment for Post-traumatic Headache
Post-traumatic Headache
Primary: Change in Headache Relief — 23 percentage of headaches resolved — p=.079
N/A N=193 Cognitive-Behavior Therapy for Posttraumatic Headache
Post-traumatic Headache · PTSD
Primary: Headache-related Disability Scores on the Headache Impact Test 6 (HIT-6) — 66.1; 66.1; 65.2; 61.9 score on a scale — p=<0.001
Phase 4 N=162 Dexamethasone for Post Traumatic Headache
Post-Traumatic Headache
Primary: Frequency of Moderate or Severe Headache After Emergency Department (ED) Discharge — 31; 29; 42; 44 Participants — p=0.751
Phase 4 N=89 Prazosin for Post-Concussive Headaches
Post-Traumatic Headache
Primary: Change From Baseline in Headache Frequency — 16.4; 18.5; -9.2; -7.4 headaches per month
Phase 2 N=87 A Study to Test if Fremanezumab Reduces Headache in Participants With Posttraumatic Headache (PTH)
Post-Traumatic Headache
Primary: DB Period: Mean Change From Baseline in Monthly Average Number of Headache Days of at Least Moderate Severity During the 12-Week Treatment Period After the First Dose of…
N/A N=79 Managing Mild Traumatic Brain Injury Related Headaches With Repetitive Transcranial Magnetic Stimulation
Traumatic Brain Injury (TBI)
Primary: Number of Headache Days Per Week — 4.2; 4.6; 3.1; 4.3 days/week — p=<0.000
Phase 2 N=6 Multidisciplinary Translational Approach to Investigate Mechanisms Predictors & Prevention of Persistent PTH
Post-Traumatic Headache
Primary: Change in the Number of Days Experiencing Moderate-to-Severe Headaches — -8; -0.33 Days
Phase 2 N=89 Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin
Posttraumatic Headache · Combat Disorders · Post Concussion Syndrome
Primary: Headache Diary — -10.7; -6.9 headaches per month — p=0.034
Phase 2 N=50 Amitriptyline to Prevent Headache After Traumatic Brain Injury
Brain Injuries · Post-Traumatic Headache
Primary: Frequency of Headaches — 10 Participants — p=.101
N/A N=26 Remotely Supervised tDCS for Persistent Post-traumatic Headache
Persistent Post Traumatic Headache · Mild Traumatic Brain Injury
Primary: Change From Baseline in the Number of Moderate-to-Severe Headache Days Per Month — -2.5; 2.3; -3.9; 1.2 Days per Month
N/A N=29 Improving Functions in MTBI Patients With Headache by rTMS
TBI (Traumatic Brain Injury)
Primary: Percent Change in Composite Score of Debilitating Headache (Intensity x Duration x Frequency) — -55.3; -1.7; -58.4; -10 percent change from baseline — p=<0.0001
Phase 2 N=79 Hyperbaric Oxygen Therapy (HBO2) for Persistent Post-concussive Symptoms After Mild Traumatic Brain Injury (mTBI)
Post-concussive Symptoms · Traumatic Brain Injury
Primary: Post-Intervation Post-concussion Symptom Scores Using RPQ - Intent to Treat — 3.5; 5.1; 4.2; 3.5 units on a scale
Early Phase 1 N=26 The Effectiveness of Osteopathic Manipulative Medicine in the Management of Headaches Associated With Post Concussion Syndrome
Headache · Post-Concussion Syndrome
Primary: Immediate Change in Headache Scores With a Visual Analog Scale (VAS) — 5.6; NA; 3.5; NA units on a scale
N/A N=38 Acupuncture in Traumatic Brain Injury
Chronic Post-traumatic Headache · Mild Traumatic Brain Injury
Primary: Change in Number of Headache Days — -8; -6 headache days
N/A N=309 Prospective ED Headache Cohort Study
Headache
Primary: Number of Participants Who Report Moderate or Severe Pain Within 24 Hours of Emergency Department(ED) Discharge — 53; 6; 20 Participants
N/A N=50 Enhanced Problem-Solving Training
Brain Concussion
Primary: Brief Symptom Inventory-18 (BSI-18) Global Severity Index T-Score — 64.21; 65.26; 66.8; 61.35 units on a scale — p=.04
Phase 2 N=71 mTBI Mechanisms of Action of HBO2 for Persistent Post-Concussive Symptoms
Traumatic Brain Injury With Brief Loss of Consciousness · Post-Concussion Syndrome
Primary: Summary of Treatment-Emergent Adverse Events — 13; 5; 5; 3 Participants
N/A N=494 Postoperative Headache in Elective Surgery Patients
Drug Withdrawal Headache
Primary: Frequency of Postoperative Headache in Elective Surgery Patients — 126; 37; 89 participants
Phase 2 N=45 Endogenous Modulation and Central Sensitization in New Daily Persistent Headache ( NDPH ) in Children
New Daily Persistent Headache (NDPH)
Primary: Pain Intensity — 5.82; 4.92 score on a scale
N/A N=80 Use of Ibuprofen and Acetaminophen for Treatment of Acute Headache Post Concussion in Children
Concussion · Headache
Primary: Number of Headache Days — 4; 3; 3; 4 number of headache days
N/A N=63 Incidence of Headache Following an Unintentional Dural Puncture
Postdural Puncture Headache · Post-Lumbar Puncture Headache · Cerebrospinal Fluid Leaks
Primary: Participants Who Report Post Dural Puncture Headaches — 21; 27 Participants — p=.877
N/A N=22 Treatment and Recovery Monitoring of Post TBI Symptoms
Brain Injuries, Traumatic
Primary: Change From Baseline in RPQ Score at Post-treatment Sessions — -4.6; -3.4 units on a scale
N/A N=23 Intracranial Pressure in Experimental Models of Headache
High Altitude Headache
Primary: Change in Optic Nerve Sheath Diameter by Ultrasonography — 0.02; 0.02 mm — p=0.98
N/A N=45 Do Patients With Chronic Daily Headache Have Continuous Headache or Moments of Headache Relief?
Chronic Daily Headache
Primary: Number of Subjects With Daily Headache Who Have Continuous Headache — 18; 27 participants
Phase 2 N=126 Levetiracetam to Prevent Post-Traumatic Epilepsy
Epilepsy · Post-traumatic Epilepsy
Primary: Post-Traumatic Epilepsy — 6; 8 participants
N/A N=98 Study of PTSD in Military Veterans Who Have Suffered Traumatic Brain Injuries
PTSD · TBI
Primary: Change in Diagnostic and Statistical Manual of Mental Disorders IV Clinician-Administered PTSD Scale DSM IV-(CAPS) — 73.13 units on a scale
Phase 4 N=50 Comparative Study Between Hydrocortisone and Mannitol in Treatment of Postdural Puncture Headache
Headache
Primary: Number of Patients (in Digits) Got Earlier Relief of PDPH (in Hours) After Use of Hydrocortisone or Mannitol. — 25; 25 Participants
N/A N=112 Peripheral Nerve Stimulation Registry for Intractable Migraine Headache
Intractable Chronic Migraine
Primary: Adverse Events (First 12 Weeks) — 17; 27; 5; 1 events