N/A N=40 Rod Sensitivity in Age-related Macular Degeneration (AMD) and Retinitis Pigmentosa (RP)
Retinitis Pigmentosa · AMD
Primary: Rod Sensitivity Within the Central Retina as Measured on the Nidek MP-3S — 7; 20 Participants — p=<0.05
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=21 Visual Activity Evoked by Infrared in Humans After Dark Adaptation
Age Related Macular Degeneration · Retinitis Pigmentosa · Congenital Stationary Night Blindness
Primary: Visual Perception to Infrared: Mean Minimal Intensity (uW) at Which Participants Could See IR Between 900 - 1400 nm. — 0.671770454; 0.809204; 0.205456012; 0.222247 uW…
N/A N=58 Blue Light Intraocular Lenses (IOLs) and Photostress
Cataract
Primary: Photostress Recovery Time in Seconds. — 36; 41.46; 24.88 seconds
N/A N=20 Wearable Dark-adaptometer in Normal Adult Healthy Volunteers
Photoreceptor Sensitivity Thresholds
Primary: Time to Rod-cone Break (RCB) — 11.34; 9.98 Minutes
N/A N=6 The Perceptual Experience of Argus II Users
Retinitis Pigmentosa
Primary: Number of Phosphenes Perceived — 1.09; 1.43; 1.46; 1.41 number of phosphenes — p=0.002
N/A N=100 Evaluation of a Night Spectacle Correction Concerning an Improvement of Mesopic Vision Quality
Myopia-Night Blindness
Primary: Night Myopia — -0.30; -0.32 D
N/A N=36 Understanding Circadian Responses to Light in Persons With Mild Cognitive Impairment
Mild Cognitive Impairment · Alzheimer Disease
Primary: Melatonin Levels — 0.89; 0.84; 0.9; 0.68 pg/mL
N/A N=40 Role of Glare and Spectral Filtering on Contrast Sensitivity: A Pilot Study
Visual Acuity
Primary: Area Under the Curve of Photopic Contrast Sensitivity Function Under Bright Light Conditions (∼120 cd/m2) With a Broadband Glare Source — 1.92; 1.62…
N/A N=20 Subthreshold Laser Treatment for Reticular Pseudodrusen and Geographic Atrophy Secondary to AMD
Age-Related Macular Degeneration · Geographic Atrophy · Reticular Pseudodrusen
Primary: Retinal Sensitivity — 12.08; 11.08; 11.45 dB — p=0.404
Phase 2 N=24 Single Dose Study of Phentolamine Mesylate Eye Drops in Patients With Severe Night Vision Disturbances
Decrease in Night Vision · Disturbance; Vision, Loss
Primary: Contrast Sensitivity — 0.6; 0.8; 0.9; 0.7 Patches
Phase 3 N=144 Safety and Efficacy of Nyxol (0.75% Phentolamine Ophthalmic Solution) in Subjects With Dim Light Vision Disturbances
Dim Light Vision Disturbances
Primary: Percent of Subjects With 3 Lines mLCVA Improvement in Study Eye — 9; 2 Participants
N/A N=60 The Use of i/t Curve in Assessment of Phototherapy Effects
Nerve Disorders
Primary: Change in the Pressure Pain Threshold (PPT) — 0.0; -0.5; -1.3; -0.6 lbs — p=0.3879
N/A N=80 Effects of Blue-light Blocking Lens on Visual Functions
Effects of Blue-light Blocking Lens on Visual Functions
Primary: Contrast Sensitivity as Assessed by Mars Contrast Sensitivity Chart — 1.866; 1.861; 1.856; 1.818 log contrast sensitivity score
N/A N=109 Macular Pigment and Glare Disability
Vision, Entoptic
Primary: Macular Pigment Optical Density — 0.54; 0.42 optical density — p=0.01
N/A N=33 Investigating the Effects of Evening Light Exposure on Melatonin Suppression, Alertness and Nocturnal Sleep
Non-visual Photoreception
Primary: Melatonin Suppression — 71.4; 70.1; 54.3; 32.5 Percentage suppression — p=0.73
Phase 2 N=9 Research Study of Treatment for Winter Depression With Different Colors of Light
Seasonal Affective Disorder
Primary: Structured Interview Guide for the Hamilton Depression Scale - Seasonal Affective Disorder Version (SIGH-SAD); Weekly for Three Weeks — 16.3; 8 units on a scale
N/A N=63 Transcorneal Electrostimulation for Therapy of Retinitis Pigmentosa
Retinitis Pigmentosa
Primary: Visual Field, III4e — 4835.29; 4988.43; 6234.59; 4488.39 deg2
N/A N=110 Infrared Choroidal Reflectance Camera for the Detection of Childhood Cataract
Childhood Cataract
Primary: Results of Red-reflex and Infrared-reflex Tests Compared to Gold Standard — 17; 54; 32; 7 eyes
N/A N=21 The Effects of Contact Lenses With UV/HEV-Filter on Visual Function
Visual Acuity
Primary: Visual Range at Phase 1 — 3.232; 3.049; 3.287; 3.167 log relative energy level
N/A N=180 Variability in Perimetry Study
Glaucoma
Primary: Number of Subjects Progressing in Each Group Using Pointwise Linear Regression — 0; 0 participants — p=.21
N/A N=50 Cone Rescue in Retinitis Pigmentosa by the Treatment of Lycium Barbarum
Retinitis Pigmentosa
Primary: ETDRS Visual Acuity (High Contrast) — -0.02; 0.11 log unit
N/A N=32 Evaluation of the Precision of the Microperimetry Function of the Spectral OCT/SLO
Age-Related Macular Degeneration · Geographic Atrophy · Diabetic Retinopathy
Primary: Standard Deviation and Mean Test Results of Normal and With Pathology Participants Taken by 3 Different Operator-device Configurations — 16.16; 12.23 decibels
Phase 2 N=78 DHA and X-Linked Retinitis Pigmentosa
Retinitis Pigmentosa · X-linked Genetic Diseases
Primary: Rate of LOSS of 31 Hertz Cone Electroretinographic Function — 0.028; 0.022 log microvolts/year — p=0.30
N/A N=51 Normative Database for Pattern Electroretinogram (PERG) and Flash Electroretinogram (FERG)
Glaucoma
Primary: Flash Electroretinogram (FERG) Module Using Diopsys NOVA (Neuro Optic Vision Assessment) Amplitude — -1.68 micro volts
Early Phase 1 N=9 Vitamin A Palmitate Supplementation in Patients With Reticular Pseudodrusen (RPD) and Delayed Dark Adaptation
Reticular Pseudodrusen (RPD) · Age-Related Macular Degeneration
Primary: Change in Dark Adaptation Rod Intercept Time (RIT) From Baseline in the Study Eye at the Treatment Completion Visit (Month 2 for Cohort 1 and Month 1 for Cohort 2)…
Phase 2 N=44 Retinal Imaging in CNTF -Releasing Encapsulated Cell Implant Treated Patients for Early-stage Retinitis Pigmentosa
Retinitis Pigmentosa · Usher Syndrome Type 2 · Usher Syndrome Type 3
Primary: Mean Change in Cone Spacing in Arcminutes (Z Score) of 2 Baseline Values Were Compared With Measurements Obtained at Post-op Month 36 — 1.13; 0.85 Difference in change…
N/A N=35 30-Minute Light Exposure for the Treatment of Seasonal Affective Disorder
Seasonal Affective Disorder
Primary: SIGH-ADS Score — 29.4; 25.8; 5.6; 4.5 units on a scale — p=0.74
N/A N=68 Functional Vision With ACRYSOF® IQ IOLs Blue Light Filtration
Cataract
Primary: Change in Braking Reaction Time From No-glare to Glare — 0.07; 0.15 seconds
Early Phase 1 N=8 Vitamin A Palmitate Supplementation in People With Age-Related Macular Degeneration (and Without Reticular Pseudodrusen) and Delayed Dark Adaptation
AMD
Primary: Change in Dark Adaptation Rod Intercept Time (RIT) From Baseline in the Study Eye at the Treatment Completion Visit (Month 2 for Cohort 1 and Month 1 for Cohort 2)…
N/A N=154 Effect of Blue Light Filtration on Visual Performance
Cataract
Primary: Photostress Recovery Time — 5.66; 6.94 seconds