Phase 4 N=49 Compare Anti-inflammatory Dentifrices
Gingivitis
Primary: Gingival Index (GI) — 1.04; 1.01 units on a scale — p=<0.05
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=32 Induced Gingivitis & Intra-oral Imaging
Plaque Induced Gingivitis
Primary: Change From Baseline Gingivitis at Day 14 as Measured by Non-invasive Microimaging and Gingival Index. — 0.6; 0.15 units on a scale
Phase 3 N=19 Investigation of Dental Plaque and Gingival Index
Dental Plaque
Primary: Gingival Margin Plaque Index — 15.4; 12.81 Units on a scale — p=0.05
N/A N=61 Trial of Toothpaste to Reduce Plaque and Inflammation
Plaque · Inflammation
Primary: Change in Oral Plaque — -1.05; -0.03 log(percentage) — p=0.001
N/A N=200 A Clinical Study to Evaluate Effects of an Oral Rinse on Plaque and Gingivitis
Plaque
Primary: Plaque Index Score Per Participant at 6 Months — 2.12; 2.70; 2.23; 2.84 score on a scale — p=<0.0001
N/A N=69 IFI16 is a Periodontitis Modulating Protein
Severe Periodontitis · Acute Inflammatory Response
Primary: Change in Absent in Melanoma 2 (AIM2) mRNA Expression Levels — 0.37; 0.65 fold change — p=0.3
Phase 3 N=15 Train New Examiners Via Modified Gingival Margin Plaque
Dental Plaque
Primary: Mean Gingival Plaque Units — 13.38; 14.29 Units on a scale — p=0.05
Phase 4 N=69 Cetylpyridium Chloride (CPC) Based Chewing Gum and Gingivitis
Gingivitis · Plaque, Dental · Periodontal Diseases
Primary: Degree of Plaque as Assessed by the Turesky Modification of the Quigley-Hein Plaque Index — 0.41; 0.43 score on a scale
N/A N=50 Curved Soft-Picks on Plaque Accumulation on Patients With Gingivitis
Gingivitis
Primary: Change in Interproximal Plaque by Modification of the Quigley-Hein Plaque Index at 14 Days — 0.03; -0.07 score on a scale
Phase 2 N=71 Safety and Tolerability of Antiplaque Chewing Gum in a Gingivitis Population
Plaque · Gingivitis
Primary: Safety and Tolerability of KSL-W as Measured by Soft Tissue Erythema, Ulceration and Sloughing (AEs and SAEs) — 2; 1; 4; 2 Participants
Phase 3 N=32 Evaluate Dental Plaque Benefit of a Preventive Treatment Gel
Dental Plaque
Primary: Mean Turesky Modified Quigley-Hein Index at Day 4 — 1.83; 1.96 score on a scale
N/A N=158 A Clinical Trial to Test the Effect of Marketed Mouth Rinses on Decreasing Plaque and Gum Inflammation
Plaque · Gingivitis
Primary: Whole Mouth Mean Modified Gingival Index (MGI) at Week 3 — 2.004; 1.770; 1.807 units on a scale — p=<0.001
Phase 3 N=73 Clinical Research Study Efficacy of a Prototype Oral Rinse
Dental Plaque
Primary: Gingival Index — 1.90; 1.84 Units on a scale — p=0.005
Phase 3 N=23 Clinical Study to Evaluate Dental Plaque
Gingival Diseases
Primary: Dental Plaque Index — 2.48; 2.42 Units on a scale — p=0.05
Phase 3 N=120 Comparative Efficacy of a Toothpaste That Reduces Plaque and Gingivitis
Gingivitis
Primary: Gingivitis Index — 1.00; 1.27 Units on a scale — p=0.05
N/A N=48 Gingival Bleeding and Von Willebrand Disease Typ 2 and 3
Gingival Bleeding · Von Willebrand Diseases
Primary: Bleeding on Probing (BOP) — 14.5; 12.3 percentage of sites
Phase 3 N=6 Effect on Bacterial Glycolytic Acid Formation on Plaque
Dental Plaque
Primary: ph of Dental Plaque After Sucrose Challenge — 4.88; 5.04; 4.98 ph of dental plaque — p=0.05
N/A N=30 Measuring Efficacy of an Oral-Irrigator After Three Weeks of Use
Gingivitis · Plaque
Primary: MGI-Modified Gingival Index — 0.30; -0.13 score on a scale
N/A N=90 A Comparative Study of Electric Toothbrushes for the Efficacy Plaque Removal and the Effect on Plaque Accumulation and Gingivitis.
Dental Plaque Induced Gingivitis · Dental Plaque
Primary: Plaque Index — 1.07; 1.19; 1.31; 1.11 units on a scale — p=0.1561
N/A N=30 The Effectiveness of Brushing and Flossing Sequence on Control of Plaque and Gingival Inflammation
Gingival Inflammation · Plaque · Gingival Bleeding
Primary: Change From Baseline in Mean BPI Index Scores at 2 Weeks — 0.396; -1.028 score on a scale — p=0.022
Phase 4 N=49 Evaluate Inflammation Caused by Gingivitis in Adults
Gingivitis
Primary: Level of Gingival Crevicular Fluid Interleukin - 1 (GCF IL-1) at 2 Hours — 492.2; 326.3 Micrograms — p=0.05
Phase 2 N=127 Safety and Preliminary Efficacy of Lipoxin Analog BLXA4-ME Oral Rinse for the Treatment of Gingivitis
Gingival Inflammation
Primary: Incidence of Adverse Events — 19; 10; 3 Participants
Phase 2 N=23 Effect of a Commercial Cosmetic Mouth Rinse on Plaque Re-growth
Healthy Subjects
Primary: Plaque Index of Test Mouth Rinse Versus Sterile Water After Day 4 of Treatment Administration — 3.03; 3.23 Score on a scale — p=0.0915
Phase 4 N=135 Six Month Plaque and Gingivitis Study Using Colgate Total Toothpaste
Dental Plaque · Gingivitis
Primary: Dental Plaque Score — 3.53; 3.55; 3.59 units on a scale — p=0.919
Phase 3 N=103 Compare the Clinical Efficacy of Prototype Toothpastes.
Gingival Diseases
Primary: Dental Plaque — 2.273; 1.806; 2.041 Units on a scale — p=<0.05
Phase 3 N=39 Collection of Gingival Crevicular Fluid From Periodontitis Patients
Gingival Diseases
Primary: Metabolite Associated With Inflammation (Cadaverine) — 1.119186; 0.92077 ion count — p=<0.05
Phase 2 N=162 The Clinical Investigation of a Zinc Based Toothpaste in Reducing Plaque and Gingivitis
Dental Plaque and Gingivitis
Primary: Gingivitis Scores — 1.48; 1.57; 1.49 units on a scale — p=0.091
Phase 3 N=102 Compare the Clinical Efficacy of Prototype Toothpastes
Dental Plaque
Primary: Plaque Index — 0.91; 0.84; 1.77 Units on a scale — p=0.05
Phase 2 N=27 Is an Antiplaque Chewing Gum (30 mg) Able to Reduce Dental Plaque in a Healthy Population?
Plaque Regrowth
Primary: Safety, Tolerability and Effectiveness in Reducing Dental Plaque of KLS-W Delivered in a Chewing Gum Formulation — 0; 0; 0; 0 participants
Phase 2 N=60 Efficacy of ClōSYS® Sensitive Fluoride Toothpaste and ClōSYS® Sensitive Rinse Regimen on MGI, PI and BOP
Gingivitis · Periodontitis
Primary: Changes in Modified Gingival Index (MGI) — 8.5; 1.5 score on a scale — p=<0.001