Early Phase 1 N=35 Dose-dependent Anti-inflammatory Effects of Vitamin D in a Human Gingivitis Model
Gingivitis
Primary: Proportion of Sites That Bleed on Probing
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Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=6 TRACER [F-18] RDG-K5 Carotid Plaque Imaging Study
Carotid Arteries
Primary: Uptake of [F-18] RGD-K5 by Carotid Plaque With PET/MRI Imaging in the Artery Believed to be the Cause of Transient Ischemic Attack (TIA) or Stroke Symptoms Compared to…
N/A N=152 A Clinical Study Investigating the Effects of a Dentifrice Containing 0.454% Stannous Fluoride on Gingivitis Treatment and Plaque Reduction When Used Twice Daily for 12 Weeks
Gingivitis
Primary: Adjusted Mean Change From Baseline in the Number of Bleeding Sites (NBS) at Week 12 — -14.6 bleeding sites — p=<0.0001
N/A N=90 A Comparative Study of Electric Toothbrushes for the Efficacy Plaque Removal and the Effect on Plaque Accumulation and Gingivitis.
Dental Plaque Induced Gingivitis · Dental Plaque
Primary: Plaque Index — 1.07; 1.19; 1.31; 1.11 units on a scale — p=0.1561
Phase 3 N=55 Effect of Evolocumab on Coronary Atherosclerosis
Cardiovascular Disease · Hyperlipidemia
Primary: Change in Noncalcified Coronary Artery Plaque Volume (NCPV) — -45 mm^3
N/A N=124 Comparison of Modified Circular and Natural Tooth Brushing Methods in Effectiveness of Dental Plaque Removal
Healthy
Primary: Baseline Plaque Level — 2.25; 2.28 plaque index — p=>0.05
N/A N=181 Clinical Evaluation of the Efficacy of a Marketed Dentifrice on Plaque and Gingivitis
Plaque · Gingivitis
Primary: Within-Treatment Whole-Mouth Differences (vs Baseline) - Gingival Efficacy — .230; .155; .3701; .205 units on a scale
N/A N=200 A Clinical Study to Evaluate Effects of an Oral Rinse on Plaque and Gingivitis
Plaque
Primary: Plaque Index Score Per Participant at 6 Months — 2.12; 2.70; 2.23; 2.84 score on a scale — p=<0.0001
N/A N=61 Trial of Toothpaste to Reduce Plaque and Inflammation
Plaque · Inflammation
Primary: Change in Oral Plaque — -1.05; -0.03 log(percentage) — p=0.001
N/A N=10 Evaluation of Toothbrush Bristles in Plaque Reduction
Plaque, Dental · Gingivitis
Primary: Change of Navy Plaque Index (Navy Pl) After One-time Brushing — 367.5; 346.5; 355; 145.4 score on a scale
Phase 2 N=162 The Clinical Investigation of a Zinc Based Toothpaste in Reducing Plaque and Gingivitis
Dental Plaque and Gingivitis
Primary: Gingivitis Scores — 1.48; 1.57; 1.49 units on a scale — p=0.091
Phase 4 N=135 Six Month Plaque and Gingivitis Study Using Colgate Total Toothpaste
Dental Plaque · Gingivitis
Primary: Dental Plaque Score — 3.53; 3.55; 3.59 units on a scale — p=0.919
N/A N=190 A Clinical Study Investigating the Effects of a Dentifrice Containing 67% Sodium Bicarbonate When Used Twice Daily for 12 Weeks on Gingivitis Treatment and Plaque Removal
Gingivitis · Dental Plaque
Primary: Adjusted Mean Change From Baseline in Number of Bleeding Sites at Week 12 — -4.3 bleeding sites — p=0.0032
N/A N=100 Efficacy of a Commercial Dentifrice Containing Ilex Rotunda Thunb Extract for Dental Plaque and Gingivitis
Gingivitis · Dental Plaque
Primary: Plaque Assessment After 6 Weeks of Dentifrice Use — 2.98; 3.04 units on a scale
Phase 3 N=120 The Clinical Efficacy of Three Oral Hygiene Regimens Using a Manual Toothbrush, Toothpaste and a Mouthwash in Controlling Dental Plaque and Gingivitis
Dental Plaque · Gingivitis
Primary: Dental Plaque Scores — 3.33; 3.19; 3.31 units on a scale — p=0.434