N/A N=10 Post Bariatric Closed Loop Glucagon Trial
Hypoglycemia
Primary: Area Over the Curve and <60 mg/dl (CGM) Measured in mg/dl *Min — 1066.30; 2004.80 mg/dl *minute
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=18 Safety and Efficacy of Exendin 9-39 in Patients With Postbariatric Hypoglycemia
Postbariatric Hypoglycemia
Primary: Postprandial Glucose Nadir — 57.1; 59.2; 47.1 mg/dL
Phase 2 N=16 Closed-Loop Glucagon Pump for Treatment of Post-Bariatric Hypoglycemia
Post-bariatric Hypoglycemia
Primary: Number of Participants With Meal-provoked Hypoglycemia, Defined as Sensor Glucose <65 mg/dL — 1; 5 participants — p=0.103
Phase 2 N=9 Effect of Mizagliflozin on Postprandial Glucose and Insulin in Post-Bariatric Hypoglycemia Subjects
Postbariatric Hypoglycemia
Primary: Glucose Nadir After Mizagliflozin Dosing — 6.2; 4.0; 17.5; 31.5 mg/dL
N/A N=62 Comparison Between Pyloric Preserving and Non-Pyloric Preserving Bariatric Surgery With Glucose Challenge
Hypoglycemia · Obesity
Primary: Mean Serum Glucose Levels — 123.1; 157.5; 103.2; 138 mg/dl
N/A N=16 Cognition in Patients With Hypoglycemia, Without Diabetes
Hypoglycemia · Cognition
Primary: Assessment of Immediate Verbal Memory — 50; 48 RAVLT scores on a scale (range 0 to 69) — p=0.90
N/A N=22 Diabetes and Gastric By- Pass
Type 2 Diabetes
Primary: Response in Glucose AUC at Baseline vs. Following Gastric Bypass Surgery — 61647.0; 59476.1 mg/dL*min
Phase 2 N=3 Efficacy, Tolerability and Pharmacokinetics of Subcutaneous Exendin (9-39) in Patients With Post Bariatric Hypoglycemia
Post Bariatric Hypoglycemia
Primary: Nadir Glucose — 41; 43; 39; 42 mg/dL
Phase 4 N=22 Pramlintide (Symlin) for the Treatment of Hypoglycemia Following Gastric Bypass Surgery
Hypoglycemia · Evidence of Previous Gastric Surgery
Primary: Plasma Glucose Levels in Response to Mixed Meal Testing - Area Under the Curve for Plasma Glucose — 2828; 2893 mg*min/dL — p=0.90
N/A N=25 Continuous Glucose Monitoring to Reduce Hypoglycemia and Improve Safety After Gastric Surgery
Hypoglycemia, Reactive · Hypoglycemia
Primary: Percentage of Time Sensor Glucose <70 mg/dL in the Masked Versus the Unmasked Phase. — 4.7; 2.9 Percentage of time — p=0.04
N/A N=7 Role of Glucagon-Like Peptide-1 in Postprandial Hypoglycemia
Postprandial Hypoglycemia
Primary: Mean Plasma Glucose Area Under the Curve (AUC 0-3h) — 22,192.5; 25,207.1; 21,715.9 mg*min/dl
Phase 2 N=7 Delivery of G-Pump™ (Glucagon Infusion) From an OmniPod® to Prevent Hypoglycemia in Post-Bariatric Surgery Patients
Hypoglycemia · Complications of Bariatric Procedures
Primary: Detection/Notification of Hypoglycemia — 9 successful events
Phase 4 N=11 The Effect of Glucomannan Soluble Fiber on Glucose Homeostasis in Patients With Roux En Y (RNY) Gastric Bypass Surgery
Hypoglycemia
Primary: Difference Score: Percent of Time Spent in Hypoglycemic State — 1.2 Difference score, trt-control (percent) — p=0.99
N/A N=48 An Analysis of Lipid and Glucose Metabolism Following Bariatric Surgery
Morbid Obesity
Primary: Triglycerides Post-prandial — 95; 71; 134 mmol/L
N/A N=34 Food Preference Following Bariatric Surgery
Obesity
Primary: Total Food Intake (Lunch Buffet) at 24 Months — 2540.1; 721 kJ
N/A N=587 Associated Factors in Perioperative Hypoglycemia in Patients With Diabetes
Diabetes · Hypoglycemia
Primary: Hypoglycemia Incidence — 53; 10 participants — p=<0.001
N/A N=41 The Effects of Glycemic Optimization Before Gastric Bypass Surgery
Type 2 Diabetes
Primary: Composite of Fasting Glucose, Glycosylated Haemoglobin c and Rates of Type 2 Diabetes Mellitus Remission. — 6; 6 Participants
N/A N=60 Impact Of Post-Bariatric Body Contouring Procedures on Patient Body Weight and Metabolism
Bariatric Surgery Candidate
Primary: Weight Changes by Kilograms — 94.3; 96.17; 96.27; 89.4 Kilo gram
N/A N=10 Bionic Pancreas in Children With Hyperinsulinism and Post-Pancreatectomy Diabetes
Hyperinsulinism · Diabetes · Pancreatic Diseases
Primary: Mean Plasma Glucose Level. — 149.666118; 162.574753 mg/dL
N/A N=88 Beta Cell Restoration Through Fat Mitigation
Prediabetes · Type 2 Diabetes · Obesity
Primary: Steady State Beta Cell Compensation — 3.01; 3.19 (nmol/L) adjusted for M/I — p=0.05
N/A N=5 Pancreatic Enzymes to Restore Digestive Function in Malnourished Gastric Bypass Patients
Obesity
Primary: Fat Absorption — 60.6 g/d — p=<0.05
N/A N=35 Resolution of Type 2 Diabetes Mellitus: Intensive vs. Conventional Glycaemic Control After Obesity Surgery
Type 2 Diabetes Mellitus · Obesity
Primary: Percentage of Patients With Type 2 Diabetes Mellitus Who Achieve Fasting Blood Glucose of Less Than 5.6 mmol/l and/or HbA1c of Less Than 6% — 4; 4 Participants
N/A N=30 Ileal Interposition With Sleeve Gastrectomy for Control of Diabetes
Diabetes
Primary: Percentage of Participants Having Remission of Type 2 Diabetes — 76.66 Percentage of Participants
Early Phase 1 N=20 Metabolic Causes of Thrombosis in Type 2 Diabetes - Question 4
Type 2 Diabetes
Primary: Percent Changes in Endothelial Function as Measured by Flow Mediated Dilation by 2D Doppler Ultrasound on Day 2 — 2; 7 percentage of change
Phase 2 N=12 The Effect of Bariatric Surgery on Metabolism, the Metabolome and Microbiome in Patients With Type 2 Diabetes
Type 2 Diabetes Mellitus · Obesity
Primary: Fasting Glucose — 6.1; 7.23; 6.48; 5.89 mmol/l
N/A N=29 Exendin-9,39 and Satiety After Bariatric Surgery
Obesity
Primary: Caloric Intake — 531; 465; 444; 494 calories
N/A N=5 Gastrectomy, Eating Behaviour and GLP-1
Gastric Cancer · Dumping Syndrome
Primary: Nadir Blood Glucose — 3; 4.4 mmol/l — p=0.008
Phase 3 N=46 Effect of GLP-1 Receptor Agonism After Sleeve Gastrectomy
Obesity
Primary: Weight — 127; 130; 126; 75 kilograms
N/A N=19 Post-Prandial Liver Glucose Metabolism in PCOS
Polycystic Ovarian Syndrome · Obesity · Hepatic Steatosis
Primary: Hepatic Fat Fraction — 8.35 Percent
N/A N=20 Hepatic Mitochondrial Function in Youth
Hepatic Steatosis · Bariatric Surgery Candidate · Adolescent Obesity
Primary: Change in Percentage of Liver Fat Per MRI — -13.93 percentage of liver fat