Clinical Trial Search

Primary: Blood-oxygen-level-dependent (BOLD) Response During Functional Magnetic Resonance Imaging (fMRI) z Statistic — 2.3; 2.0; 2.1; 1.7 z score — p=.27

Primary: Change in Edinburgh Depression Scale From Baseline — 17.81; 17.9; 12.04; 11.41 units on a scale

Primary: Hamilton Rating Scales of Depression — 12.09; 17.17 units on a scale — p=.01

Primary: Score on the Edinburgh Postnatal Depression Scale (EPDS) — 5.04; 4.36; 4.43; 4.04 score on a scale

Primary: Change From Baseline (CFB) in the 17-item Hamilton Rating Scale for Depression (HAM-D) Total Score at Day 15 — 28.8; 28.6; -11.4; -15.6 score on a scale — p=0.0007

Primary: Depression Symptoms — 10.1; 11 score on a scale

Primary: The Parent Child Early Relational Assessment (PCERA) — 3.0; 3.2; 3.3; 3.3 score on a scale

Primary: Number of Participants With Treatment Emergent Adverse Events (TEAEs) and Treatment Emergent Serious Adverse Events (TESAEs) — 4; 0 Participants

Primary: Number of Participants With Treatment-Emergent Adverse Events (TEAEs) — 4; 3; 5 Participants

Primary: Edinburgh Postnatal Depression Scale (EPDS) Mean Total Score — 3.75; 3; 0; 1.14 Units on a scale

Primary: Structured Clinical Interview for DSM-IV Axis I Disorders — 7.94; 8.20 percentage of participants

Primary: Change in Hamilton Rating Scale for Depression (HRSD) Score, Minus the Sleep Item — -7.62; -5.92; -8.21; -6.18 change in score — p=.367

Primary: Parts A and B: Change From Baseline in the 17-Item Hamilton Rating Scale for Depression (HAM-D) Total Score at Day 15 — -13.6; -17.8 score on a scale — p=0.0028

Primary: Change in Clinician-rated Montgomery-Asberg Depression Rating Scale (MADRS) — -21.33 units on a scale

Primary: Change From Baseline at End of Treatment Period (at 60 Hours) in Hamilton Rating Scale for Depression (HAM-D) Total Score — -8.75; -20.97 score on a scale — p=0.008

Primary: Duration of Breastfeeding Among Women Who Plan to Breastfeed Their Infants After Postpartum or Delayed (4-6 Weeks Postpartum) Initiation of DMPA — 71; 70; 4; 4…

Primary: Hamilton Depression Rating Scale (HAM-D) — 22.0; 21.8; 22.0; 8.8 units on a scale

Primary: Change in Edinburgh Postnatal Depression Scale Score (EPDS) — -4.3; -4.2 score on a scale

Primary: Attendance — 83.3; 3.3 percentage of participants

Primary: Recent PrEP Adherence — 33; 18 Participants — p=<0.001

Primary: Treatment Effect on Mother-infant Bonding — 99.33; 99.35; 101.11; 97.90 score on a scale — p=0.5

Primary: Change From Baseline at 60 Hours in 17-Item Hamilton Rating Scale for Depression (HAM-D) Total Score — -12.12; -14.62 score on a scale — p=0.0160

Primary: Change From Baseline in Hamilton Depression Rating Scale 17-item Version (HAMD17) Through Treatment — -8.0; -5.7; -0.8; -2.6 score on a scale

Primary: Change From Baseline in Hamilton Depression Rating Scale 17-item Version (HAMD17) Total Score — -13.0; -12.0; -14.0; -14.3 Scores on a scale

Primary: Change in Primary Health Questionnaire (PHQ-9) — 10.68; 10.24; 5.78; 7.48 score on a scale — p=.003

Primary: Edinburgh Postnatal Depression Scale — 41; 35; 37 score on a scale

Primary: Change From Baseline at 60 Hours in the 17-Item Hamilton Rating Scale for Depression (HAM-D) Total Score — -14.04; -19.54; -17.72 score on a scale — p=0.0013

Primary: Depression Treatment Outcome — 0.96; 1.33 units on a scale

Primary: Number of Participants Who Relapsed by Week 4 Postpartum — 6; 7 participants

Primary: Change From Baseline Resilience at 4 Weeks — 26.57; 28.29; 1.85 score on a scale — p=<.001