N/A N=28 The Influence of Antibiotic Prophylaxis on Intraoperative Prosthetic Joint Infection Cultures
Prosthetic Joint Infection
Primary: Positive Cultures — 7; 7 cultures
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=32 Microcurrent Dressing to Treat Infections, Before, During and After Surgery
Shoulder Arthropathy Associated With Other Conditions · Shoulder Arthritis · Shoulder Osteoarthritis
Primary: Measurement of Change in Cutibacterium Acnes — 3; 8; 3; 2 Participants — p=0.004
Phase 1 N=1,999 Vancomycin Powder and Dilute Povidone Iodine Lavage for Infection Prophylaxis in High Risk Total Joint Arthroplasty
Osteoarthritis
Primary: Rate of Periprosthetic Infection (PJI) After Elective Total Joint Arthroplasty. — 7; 0; 3; 2 Participants
Phase 2 N=15 Safety and Efficacy in Patients Treated for Hip or Knee PJI With Vancomycin and Tobramycin Joint Irrigation
Prosthetic Joint Infection
Primary: Safety Evaluations: Number and Frequency of Adverse Events Among Participants — 14; 14; 14; 14 Participants
N/A N=260 MICRO Study: Detecting Bacterial Infections Related to Orthopaedic Surgical Implants
Open Reduction and Internal Fixation of Extremity Fractures
Primary: Number of Blood Samples With High Levels of Absorbance Via ELISA for Patients (Greater Than 1.5 Ratio Compared to Control Human Serum) — 48; 53 blood draw samples
N/A N=156 Diagnostic Utility of a Novel Point-of-Care Test of Calprotectin for Revision Total Knee Arthroplasty
Prosthetic Joint Infection
Primary: Calprotectin POC — 1; 3; 52; 29 Participants
Phase 3 N=230 Antimicrobial Barrier Dressing Versus Closed-incision Negative Pressure Therapy in the Obese Primary Total Joint Arthroplasty
Osteoarthritis
Primary: Visual Analog Scale (VAS) Pain Score — 64; 61 score on a scale
Phase 4 N=23 Intraosseous Vancomycin in Primary Total Hip Arthroplasty - Designing a Protocol
Prosthetic Joint Infection · Vancomycin · Joint Diseases
Primary: Systemic Vancomycin Level - Start of Case — 27.98; 0 ug/mL
Phase 4 N=87 Prophylaxis of Periprosthetic Joint Infections With Calcium Sulfate Beads in Patients With Non-modifiable Risk Factors.
Infection
Primary: Partipants Achieving a Lower Hip or Knee Periprosthetic Joint Infection Rate With Local Versus Conventional Intravenous Antibiotic Prophilaxys, Measured With CRP, ERS in…
N/A N=225 Incidence and Risk Factors for Surgical Site Infection After Intramedullary Nailing of Femoral and Tibial Fractures
Fracture Fixation, Intramedullary · Surgical Wound Infection
Primary: Incidence of Surgical Site Infection (SSI) Relating to Intramedullary Nailing for Fixation of Diaphyseal Femoral and Tibial Fractures — 26; 195 Participants
Phase 4 N=1,054 Oral Versus Intravenous Antibiotics for Bone and Joint Infections (OVIVA B&J)
Bone Infection · Joint Infection
Primary: The Frequency of Definite Failure of Infection Treatment. — 67; 74 Participants
Phase 2 N=76 Abbreviated Protocol for Two-Stage Exchange
Prosthetic Joint Infection
Primary: Composite Endpoint of Overall Success at 90 Days — 33; 11 Participants — p=<0.0001
N/A N=146 Antibiotic Prophylaxis in Orthopaedic Traumatology
Fractures, Closed · Wounds and Injuries
Primary: Number of Participants With Total Wound Infections — 4; 9 participants — p==0.12
N/A N=91 Topical Antibiotic Treatment for Spine Surgical Site Infection
Surgical Wound Infection
Primary: Surgeon Attitudes About Using Intra-wound Antibiotics for Spine Surgery — 9; 36; 46 Participants
N/A N=10 Microbiome and Metagenome in Percutaneous Osseointegrated Prostheses (MMPOP)
Transfemoral Amputation
Primary: Bacterial Community Types as Determined by Percentage RNA Sequence Reads — 3.4; 4.6; 4.7; 8.7 Percentage RNA sequence reads — p=<0.05
N/A N=80 Skin Prep to Reduce Postoperative Shoulder Infection
Shoulder Infection
Primary: Skin Swab and Culture With Colony Forming Units (CFUs) — 39; 51; 35; 22 negative skin cultures — p=0.68
Phase 3 N=1,010 Perioperative Antibiotic Therapy to Prevent Cardiac Implantable Electronic Device Infections.
Sick Sinus Syndrome · Complete Heart Block · Syncope
Primary: Number of Patients With a Major Cardiac Implantable Electronic Devices (CIED) Infection — 5; 6 Participants
Phase 4 N=60 Antibiotic Elution in Total Knee Arthroplasty
Total Knee Replacement
Primary: Amount of Vancomycin and Tobramycin Eluted From Hand Mixed Cement With Both Antibiotics After Total Knee Arthroplasty — 23.9; 30.6; 12.6; 16.2 mg/mL
Phase 4 N=1,697 Prevention of Surgical Site Infections: Effectiveness of Nasal Povidone-Iodine and Nasal Mupirocin
Surgical Site Infection
Primary: Surgical Site Infections Occurring Within 12 Months of Surgical Procedure — 0; 5 participants
N/A N=56 Can Addition of Doxycycline Perioperatively Reduce Propionibacterium Acnes in Shoulder Arthroplasty?
Osteoarthritis
Primary: Bacterial Culture — 14; 15 # Participants with Bacteria in Culture
Phase 2 N=75 Study of Daptomycin in Subjects Undergoing Surgery for Osteomyelitis Associated With an Infected Prosthetic Caused by Staphylococci
Osteomyelitis
Primary: Any Creatine Phosphokinase (CPK) Elevation > 500 Units Per Liter (U/L) — 4; 5; 2 Participants
N/A N=262 Acinetobacter Baumannii-related Osteomyelitis: Clinical and Epidemiological Characterization
Osteomyelitis
Primary: Description of the Clinical and Epidemiological Profile of Patients With Infection — 92; 26; 25; 21 Participants
Phase 2 N=44 Tolerability, Safety, and Efficacy of Tedizolid as Oral Treatment for Bone and Joint Infections (OTTER)
Bone and Joint Infection
Primary: Quantify the Tolerability of Tedizolid for Bone and Joint Infections, Both Hardware and Non-hardware Associated — 0; 0 participants
N/A N=36 Hydrogen Peroxide to the Wound Following Surgical Incision Affecting Cultures in Primary Shoulder Arthroplast
Primary Anatomic or Reverse Total Shoulder Arthroplasty
Primary: Number of Positive vs Negative Culture's Based on Skin Prep Method — 6; 6; 12; 11 Participants
Phase 4 N=20 Intraarticular Antibiotic in TKA
Antibotics in Cementless Knees
Primary: Concentration of Antibiotics in Cementless Knees Post op — 1702.5; 582.5; 56.1; 1943 micrograms per milliliter
Phase 4 N=60 SURGX Antimicrobial Gel Versus Povidone-iodine Skin Incision Prep in Total Shoulder Arthroplasty
Surgery · Surgical Site Infection · Cutibacterium Acnes
Primary: Presence of Bacteria Within Shoulder Culture Using Incisional Prep vs. no Prep — 11; 9; 6 Participants — p=0.275
N/A N=648 Evaluating Advantages of Prevena After Hip and Knee Arthroplasty
Infection of Total Hip Joint Prosthesis
Primary: Number of Participants With Hospital Readmissions — 15; 3 Participants
Phase 4 N=100 Post-Operative Colonization Rates of Femoral Nerve Catheters Treated With Chlorhexidine-Impregnated Patch
Catheter Infections · Spinal Catheter (Epidural) (Subdural); Complications, Infection or Inflammation
Primary: Catheter Tip Colonization — 2; 3 participants
Phase 4 N=99 Efficacy of Ipack Block and Surgeon's Joint Infiltration in Total Knee Arthroplasty
Osteo Arthritis Knee
Primary: Narcotic Consumption — 15.87; 13.67 morphine equivalents, mg
Phase 3 N=22 Regional Prophylactic Vancomycin in Revision Total Knee Replacement
Arthropathy of Knee Joint
Primary: Mean Concentration of Vancomycin in Subcutaneous Fat — 94.1; 3.2; 88.3; 5.0 µg/g — p=<0.0001