Phase 2 N=9 CC-10004 For The Treatment Of Vulvodynia
Vulvodynia
Primary: Global Response Assessment — 5 participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=31 M-gCBT for Women With Provoked Localized Vulvodynia
Provoked Localized Vulvodynia
Primary: Tampon Test — -2.43; -1.88 units on a scale
Phase 3 N=31 Savella in Treatment for Provoked Vestibulodynia
Vestibulodynia · Vulvodynia
Primary: Pain Rating Index — 12.3 units on a scale — p=.001
Phase 2 N=209 Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments
Vestibulodynia · Temporomandibular Disorder · Fibromyalgia Syndrome
Primary: Pain Score During the Tampon Test — 4.37; 3.75; 4.04; 4.36 score on a scale — p=0.3630
Phase 3 N=9 Novel Topical Therapies for the Treatment of Genital Pain
Female Genital Diseases
Primary: Reduction in Daily Genital Pain. — 2.4; 2.92; 3.42; 2.77 units on a scale — p=0.30
N/A N=89 A Trial of Gabapentin in Vulvodynia: Biological Correlates of Response
Vulvodynia
Primary: Tampon Test Pain Intensity — 4.29; 3.96 units on a scale — p=0.07
N/A N=89 Effect of Acupuncture on Patient Vulvodynia Outcomes
Vulvodynia · Vulvodynia, Generalized · Vulvar Vestibulitis
Primary: Average Pain Intensity Will be Measured With the Pain Intensity Numbers Scale (PINS). — 3.90; 3.51; 2.48; 2.22 score on a scale — p=0.702
N/A N=130 Integrated Mindfulness-based Cognitive Behaviour Therapy Versus Cognitive Behaviour Therapy for Provoked Vestibulodynia
Provoked Vestibulodynia
Primary: Change in Vulvslgesiometer Pain Rating From Baseline to One Month Post-treatment to 6 Months Post-treatment — 6.66; 6.62; 3.21; 3.60 score on a scale
Phase 3 N=50 Therapy to Prevent Sexual Pain in Breast Cancer Survivors
Vulvodynia · Dyspareunia · Breast Cancer
Primary: Prevention of Entry Dyspareunia With Non-hormonal Therapy — 5.3; 1.04; NA; 0.57 Units on a scale — p=0.0149
Phase 4 N=50 Treating Postmenopausal Dyspareunia Where it Hurts
Dyspareunia
Primary: Change in Median Dyspareunia Pain Scores After 4 Weeks Using Study Drug — -1.5; -3 score on a scale — p=0.08
Phase 2 N=75 Preoperative Levator Ani Muscle Injection and Pudendal Nerve Block for Pain Control After Vaginal Reconstructive Surgery
Pelvic Organ Prolapse · Surgery · Postoperative Pain
Primary: Primary Postoperative Pain Measured by the Numerical Rating Scale (NRS) — 3.0; 4.0; 3.75 score on a scale — p=0.39
N/A N=58 Intra-vaginal Electrical Stimulation Device Compared to Sham Device for Chronic Pelvic Pain
Pelvic Pain
Primary: Change From Baseline in Pain on the Visual Analog Scale (VAS) at Week 12 — -8.5; -7.4 units on a scale — p=0.8979
N/A N=56 Dyspareunia and Central Sensitization
Endometriosis · Central Sensitisation · Dyspareunia
Primary: Deep Dyspareunia Score — 3.08 scores on a scale
N/A N=22 Nociceptive Pain Fiber Response
Painful Peripheral Diabetic Neuropathy
Primary: Changes in Small Nerve Fiber Density by Assessment of a Skin Biopsy Comparing Baseline to Day 60 — .1; .1 nerve fibers / mm squared
N/A N=16 Surface Stimulation for Female Sexual Dysfunction
Female Sexual Dysfunction
Primary: 6 Weeks - Total FSFI Score — 26.0; 17.4 score on a scale — p=0.109
N/A N=9 Effect of Peripheral Neuromodulation on Vaginal Blood Flow
Female Sexual Dysfunction · Spinal Cord Injuries
Primary: Percent Change in Average Vaginal Pulse Amplitude (VPA) During Stimulation From the Average Baseline Value — 3.3; 3.5 Percent change
N/A N=32 Injection of Botox in the Perineal Muscles in Resistant Cases of Vaginal Spasm
Vaginismus
Primary: Success of Repeated Penetration of the Penis Through the Vaginal Introitus Into the Vagina Without or With Acceptable Pain — 28 participants
Phase 4 N=199 Investigation to Minimize Prolapse Recurrence of the Vagina Using Estrogen
Pelvic Organ Prolapse · Urogenital Prolapse · Vaginal Vault Prolapse
Primary: Surgical "Failure" Defined by (i) Anatomic Assessment of Prolapse, (ii) Presence of Bulge Symptoms, and/or (Iii) Retreatment of Prolapse — 18; 8 Participants
Phase 4 N=59 Vaginal Estrogen on Postpartum Atrophy, Perineal Pain, and Sexual Function
Vaginal Atrophy
Primary: Vulvar Assessment Scale (VUAS) — 0.10; 0.20 score on a scale
Phase 4 N=10 Vulvoscopy Changes of the Vulva, Vestibule and Vagina With Daily Ospemifene in Women With Dyspareunia From VVA
Vulvovaginal Atrophy · Dyspareunia
Primary: Visible Changes to the Vulva, Vestibule and Vaginal Region on Photography — 8 points improvement on VGTA scale — p=0.05
N/A N=15 Effect of Peripheral Neuromodulation on Vaginal Blood Flow - Study 2
Female Sexual Dysfunction · Female Sexual Dysfunction Due to Physical Condition
Primary: Maximum Percent Change in Vaginal Pulse Amplitude (VPA) From the Average Baseline Value — 119.8; 94.3; 135.4; 113.5 percent change of VPA
Phase 2 N=49 Vaginal Diazepam for the Treatment of Female Pelvic Pain
Pelvic Floor Disorders · Pelvic Pain
Primary: Visual Analog Scale (VAS) for Pain — 50; 39 score on a scale — p=0.62
N/A N=30 Clinical Investigation to Assess the Safety and Efficacy of the Laser for the Treatment of Vulvovaginal Atrophy
Vulvovaginal Atrophy
Primary: The Main Outcome of the Study is the Efficacy of the Laser Procedure, Intended as the Amelioration of 50% of the Severity of the Vaginal Dryness at 12 Months, Compared…
N/A N=47 Radiofrequency and Hybrid Fractional Laser for Vaginal Rejuvenation
Vaginal Atrophy
Primary: Vulvovaginal Symptoms Questionnaire — 8; 7.88; 5.93; 5.93 score on a scale
N/A N=69 Efficacy of Pain Neuroscience Education in Genito-Pelvic Pain/Penetration Disorder. A Randomized Controlled Trial.
Pain · Dysfunction Sexual
Primary: Visual Analogue Scale — 5.3; 5.8; 5.1; 3.8 score on a scale
N/A N=12 The CO2RE® System for Vulvar Lichen Sclerosus
Vulvar Lichen Sclerosus
Primary: Average Scores for VLS Clinical Signs Present At Baseline, 3, 6 and 12 Months After the Last Treatment as Assessed by the Investigators — 1.85; 0.65; 0.65; 0.73 score on…
N/A N=40 Addition of Pudendal Blocks to Pelvic Floor Physical Therapy for the Treatment of Pelvic Floor Tension Myalgia
Pelvic Floor Muscle Spasm
Primary: Visual Analog Pain Score After 6 Weekly Injections — 3.33; 2.99 Visual Analog Pain Score
N/A N=30 Feasibility of Use of Vibrators With Vaginal Dilators for Vaginismus. (Vibrator Therapy and Dilators in Vaginismus)
Vaginismus
Primary: Is Vibration Therapy (Through the Use of Handheld External Vibrators on Clitoral and Vulval Area) Acceptable to Women as Part of Medical Management of Vaginismus and…
Phase 2 N=54 Topical Anesthetic Use In Pessary Management
Pain
Primary: VAS Score at the Time of Pessary Removal Adjusting for Baseline Pain — 1.76; 3.81 Centimeters — p=.02
Phase 3 N=302 The Vaginal Health Trial
Atrophy of Vagina · Menopause · Dyspareunia (Female)
Primary: Most Bothersome Symptom (MBS) Severity — -1.2; -1.0; -0.2; -1.4 units on a scale — p=0.25