N/A N=7 Sensory Afferents for Deep Pressure Sensation
Normal Physiology
Primary: Difference Between Arms in the Change of Pressure Intensity From Baseline to After Loss of A-beta Sensation — -25.0 Units on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=15 A Device to Determine Return of Sensation From Spinal Block
Sensation Diminished, Pinprick
Primary: Block Recovery Time (Device) — 40.7 minutes
N/A N=22 Characterization of Transient Alterations of Cutaneous Sensory Nerve Function by Cryolipolysis
Adiposity
Primary: Vibration Detection Threshold (VDT) — 26.3; 19 (um/sec)
N/A N=4 Epidural Spinal Cord Stimulation for Sensory Restoration and Phantom Limb Pain in Upper-Limb Amputees
Phantom Limb
Primary: Stimulation Thresholds to a Variety of Stimulus Parameters — 2.13 milliamps
N/A N=101 Variable Perception of Cutaneous Stimulation
Pain, Acute · Anesthesia, Local · Dermatology/Skin - Other
Primary: Numeric Rating Score — 2.0; 1.2 score on a scale — p=< 0.05
N/A N=28 Research Study to Determine Sensitivity to Gentle Touch and Pressure During an Active Migraine Attack.
Migraine
Primary: Proportion of Subjects With Allodynia During a Migraine Attack — 15 participants
N/A N=8 Peripheral Sensory Input in Central Post Stroke Pain (CPSP)
Central Post Stroke Pain
Primary: Reduction in Spontaneous Pain Intensity After a Peripheral Nerve Block. — 6.5; 0.0 units on a scale
N/A N=10 Autofluorescent Flavoprotein Imaging of Intraepidermal Nerve Fibers: a Pilot Study
Small Fiber Neuropathy
Primary: AFI-intensity After Nociceptive Stimulation — 0.60; 0.25; 0.50 unitless
N/A N=31 Study To Assess The Reproducibility And Sensitivity Of Quantitative Sensory Testing In Patients With Neuropathic Pain
Neuropathic Pain
Primary: Mean Change From Baseline in Dynamic Allodynia Intensity at Visits 3 and 6 and Visits 4 and 7 — -1.09; -1.16; -1.31; -0.67 scores on a scale — p=0.7319
Phase 4 N=16 Pathophysiology of Post Amputation Pain
Amputation Stumps · Neuroma
Primary: Change in Pain — -0.3; -2; -1; 1.3 units on a scale
N/A N=20 Somatosensory Profiling in Radicular Pain Patients And it's Correlation With Treatment Outcome
Radiculopathy · Lower Extremity Radicular Pain
Primary: Pre-epidural Warm Sensation Quantitative Sensory Testing (QST) Results — 2.68; 5.67 Degrees Celsius — p=.04
N/A N=42 A New Method for Identifying Sensory Changes in Painful Chemotherapy-induced Peripheral Neuropathy (CIPN)
Chemotherapy-induced Peripheral Neuropathy
Primary: Aδ:C Fiber Detection Threshold Ratio — 2.04; 1.57 ratio — p=0.05
N/A N=140 Effectiveness of the Precision Spinal Cord Stimulator System at Sub-Perception Amplitude
Chronic Pain
Primary: Proportion of Subjects With 50% or Greater Reduction in Overall Pain Intensity From Baseline — 32; 41 Participants
N/A N=30 Effects Of Sensory Training and Electrical Stimulation on Sole of The Foot Sensations in Patients With Acute Hemiplegia
Hemiplegia · Stroke, Acute · Sensory Disorders
Primary: Assessment Of Joint Position Sense — 5.0; 6.4; 8.1; 8.6 correct responses
N/A N=34 Lidocaine for Diabetic Peripheral Neuropathy
Diabetes · Peripheral Neuropathy · Pain
Primary: Change in Spontaneous Pain at 60-120 Minutes After Lidocaine Infusion Initiated (Assessed on 0-10 NRS) — 33; 51 percentage of pain change from baseline — p=0.03
Phase 2 N=39 Lidocaine Patches Prior to Percutaneous Nerve Evaluation
Overactive Bladder · Urge Incontinence · Fecal Incontinence
Primary: Visual Analog Scale Pain Score — 45; 61 mm
N/A N=22 Nociceptive Pain Fiber Response
Painful Peripheral Diabetic Neuropathy
Primary: Changes in Small Nerve Fiber Density by Assessment of a Skin Biopsy Comparing Baseline to Day 60 — .1; .1 nerve fibers / mm squared
N/A N=13 Assessment of Laryngopharyngeal Sensation in Adductor Spasmodic Dysphonia
Spasmodic Dysphonia · Adductor Spasmodic Dysphonia · Voice Disorders
Primary: Laryngeal Adductor Reflex — 13 Participants
N/A N=11 Effect of Prolonged Electrical Stimulation on Neural Plasticity in Spinal Cord Injury
Spinal Cord Injury
Primary: Conduct pre-and Post-training Assessments of Behavioral Outcomes Using Wolf Motor Function Test and Jebsen Taylor Hand Function Test to Measure Upper Extremity Function…
Phase 2 N=61 Synera Venipuncture Pain
Pain · Phlebotomy · Palliative Care
Primary: Percentage of Patients With No or Minor Pain (VAS<3) — 38.0; 21.3 percentage of participants
N/A N=143 Pain and Sensory Changes Assessment in HIV+ Patients
HIV Infections
Primary: Number of Participants With Chronic Myogenic Pain, TMJ Disoder, and Burning Mouth Syndrome — 72; 8; 37; 7 Participants
N/A N=250 Evaluation of Blood Volume and Perceived Pain During Fingerstick Monitoring of Blood Glucose
Diabetes Mellitus, Type 1 · Diabetes Mellitus, Type 2
Primary: Blood Sample of Sufficient Volume to Yield a Valid Meter Reading — 245; 246; 124; 63 Participants
N/A N=33 Electrical Stimulation for the Treatment of Post-Amputation Pain Using the SPRINT System
Post-Amputation Pain · Phantom Limb Pain · Residual Limb Pain
Primary: Proportion of Group 1 (Treatment) and Group 2 (Control) Subjects That Achieved ≥ 50% Reduction in All Qualifying Areas of Pain in the First 4 Weeks of Treatment — 7; 2…
N/A N=31 Effects of Transcranial Direct Current Stimulation (tDCS) on Neuropathic Symptoms Following Burn Injury
Burn Injury · Chronic Pain · Pruritus
Primary: Change in Pain Scale — 4.45; 4.19 units on a scale
Phase 3 N=626 The Efficacy of a Toothpaste to Reduce Sensitivity
Dentin Hypersensitivity
Primary: Hypersensitivity Tactile(Yeaple Probe) — 19.81; 13.94 units on a scale — p=0.05
Phase 4 N=120 Ultrasound-guided Axillary Plexus Block - Dose Reduction of Prilocaine
Other Surgical Procedures
Primary: Number of Participants With Complete Sensory Block — 38; 39; 39 participants — p=1
Phase 1 N=259 Contact Sensitization Potential of 828 Ointment
Healthy Volunteers
Primary: Number of Participants That Exhibited a Score Less Than 1.5 on the Jordan-King Scale — 205 participants
Phase 4 N=64 Comparison of Two Topical Anesthetics: Benzocaine Versus Pliaglis
Anesthesia of Mucous Membrane
Primary: Measurement of Pain Associated With Injection, in Millimeters, According to Visual Analog Scale — 38.5; 26.9 mm
N/A N=30 A Pilot Study to Assess Nominal Versus Controlled Stimuli on Dentinal Hypersensitivity
Dentin Sensitivity
Primary: Change From Baseline for Visual Analog Scale - Cold Water — -22.93 Units on a scale
N/A N=134 Effect of a Vibratory Stimulus on Mitigating Nociception-specific Responses to Skin Puncture in Neonates
Infant, Newborn · Infant, Premature · Pain Perception
Primary: Change in Nociception-specific Brain Activity — 17.9; 9.9; 11.5; 10.2 microvolts*milliseconds — p=<0.001