Clinical Trial Search

Primary: Change From Baseline in Mean Oxygen Consumption (mL/kg/Min) at 6 Weeks — 30.5; 30.5; 31.3; 31.3 mL/kg/min — p=0.73

Primary: To Evaluate the Incidence of the Pre-proendothelin SNP at Nucleotide 5665 — 10 participants

Primary: Area Under the Curve for Ambrisentan Plasma Concentration — 7871.46 ng*hr/mL

Primary: Feasibility Evaluation and Major Cardiac Adverse Events Related to Transcoronary Infusion of Cardiac Progenitor Cells — 0; 0 participants

Primary: Maximum Sildenafil Plasma Concentration — 181; 515; 545; 202 ng/mL

Primary: The Number of Graft Related Post-operative Complications That Require a Repeat Surgery or a Non Surgical Treatment Within 12-month Post Implantation. — 0 Participants

Primary: Length of Hospital Stay Following Fontan — 11.2; 11 days

Primary: The Change in Exercise Capacity Measured Via Maximum Oxygen Consumed During Exercise (VO2) — 39.4; 36.8; 41.2; 34.4 ml/min/kg

Primary: Chest Tube Drainage — 686.83; 535.50 ml/kg

Primary: End-systolic Elastance — 0.85; 1.8 Ees in mmHg/ml/m2

Primary: Pulmonary Blood Flow as Determined by MRI Velocity Encoding at 3-6 Months — 3.3; 4.4 L/min — p=0.03

Primary: Change in VO2 Max — 1.33; 0.745 Change in ml/kg min

Primary: Change in Peak Oxygen Uptake From Baseline Peak Oxygen Uptake — -2.01; -1.01 ml/kg/min

Primary: Change From Baseline in Peak Oxygen Uptake/Consumption (VO2) Up to Week 16 — -0.67; -0.16 Milliliter/kilogram/minute (mL/kg/min) — p== 0.1930

Primary: Peak Oxygen Uptake — 15 ml/kg/min

Primary: Liver Stiffness as Measured by Magnetic Resonance Elastography (MRE) — 5.69; 5.72; 5.02; 5.68 kPa

Primary: Hemodynamics as Characterized by Vasoactive Inotrope Score (VIS) — 11; 11.3 units

Primary: Proportion of Patients Who Died or Received a Heart Transplant — 100; 72 Participants — p=0.013

Primary: Change in Pulmonary Pulsatility Index — 51.6; 57.6 Ratio — p=0.1

Primary: Change in Peak VO2 Between Baseline and Post-inspiratory Muscle Training Measurements. — 24.0 ml/kg/min — p=0.1673

Primary: Number of Subjects With Left Ventricular Recovery and LVAD Explant — 8 Participants

Primary: Impaired Post-operative Functional Capacity — 35 Participants

Primary: Changes in End Diastolic and End Systolic Volume as Measured by Standard and Advanced MRI Parameters — 3.3; 3.0; 3.0; 4.4 ml

Primary: Cardiac Index — 3.39; 3.42; 3.23 L/min/m2

Primary: Shear Wave Speed (Liver Stiffness) — 1.18; 2.28; 2.22; 2.08 meters per second — p=<0.0001

Primary: Feasibility of Pacemaker Implant With Total Thoracoscopic Approach to Epicardial Pacing Lead — 100 percentage of particiapants

Primary: Time to First Post-operative Negative 24 Hour Fluid Balance — 2.7; 2.67 Days

Primary: Weight-for-age Z-score at 14 Months of Age — -0.62; -0.42 standard deviation — p=0.28

Primary: Percentage of Participants With Any Thrombotic Event (Venous or Arterial and Symptomatic or Asymptomatic) — 8.3; 1.6; 8.8; 0 percentage of participants

Primary: Freedom From Device or Procedure Related Death or Reintervention — 97.1 percentage of participants