Clinical Trial Search

Primary: Number of Genes Upregulated or Downregulated as Assessed by RNA Sequencing (Older Group, Retinol Versus Placebo) — 23; 21 genes

Primary: Inter-rater Reliability of Assessment of Facial Lines Using the 4-Point Facial Wrinkle Scale (FWS-A) — 0.653; 0.637; 0.647; 0.654 Kappa statistics

Primary: Number of Participants With Effectiveness and Safety Success — 30; 41 participants

Primary: The Change in Skin Tightening in the Upper Inner or Outer Arm (as Measured by Millimeters) — 45.17 millimeters

Primary: Change From Baseline in Ra (a dermaTOP Parameter), of Test Product Treated Versus (vs.) Untreated Side at Day 29 — -1.90; -0.12 Micro meter (µm) — p=0.0638

Primary: Change in Neck and Facial Wrinkles Using the Fitzpatrick Wrinkle Assessment — 74 percentage of participants

Primary: Subject Satisfaction — 2.8 score on a scale

Primary: Change From Baseline in Overall Dry Skin Score (ODS) — -0.9; -1.2; -0.9 units on a scale

Primary: Skin Aging Measured With the Photonumeric Scale. — 21.25; 21.36; 21.21; 21.03 Units on a scale

Primary: Assessment of Wrinkle Severity Using the Lemperle Wrinkle Assessment Scale — 3.31; 2.45 Score on a Scale — p=<0.01

Primary: Change in Facial Wrinkles at 12 Weeks Post Final Treatment Compared to Baseline — -0.10 units on a scale

Primary: Photographic Knee Laxity and Texture Evaluation — 1.87; 2.02 score on a scale

Primary: Analysis of Elasticity (Collagen & Elastin) — 1.7; 0.5; 1.5; 0.5 units on a scale

Primary: Changes to the Surface by Visual and Photographic Analysis. — 41 participants

Primary: Fitzpatrick Wrinkle Assessment — 1.0; 1.5; 1.1 units on a scale, change in Fitzpatrick

Primary: Overall Improvement in Periorbital Wrinkles and Rhytids Around the Eyes — 47; 50 percentage of participants improved

Primary: Fitzpatrick Classification of Wrinkling and Degree of Elastosis. — 5.6; 5.56; 5.36; 5.32 Fitzpatrick Classification Scale

Primary: Percent Change From Baseline in Microtopographic Profilometry Ra Values (Skin Roughness). — 3.62; 18.57 Percent change post-treatment — p=<0.0001

Primary: Principal Investigator's Assessment of Improvement at 12 Weeks Post-final Treatment (Physician's Global Assessment of Improvement=GAIS) — 1.04 score on a scale

Primary: Hydration Level — 53.19; 46.75 AU (arbitrary unit) — p=<0.05

Primary: Percentage of Treated Subjects With Improvement in Lines and Wrinkles of the Décolleté at Day 90 — 62.2 percentage of subjects

Primary: Blistering Time (Full Blister) — 63; 54; 65; 62 Minutes

Primary: Percentage of Participants With Safety Adverse Events — 3.92 Percentage of Participants

Primary: Responder Rate for Décolleté Wrinkles According to the Merz Aesthetics Scale (MAS)-At Rest Scale as Assessed by the Blinded Live Rater — 71.8; 83.7; 73.5 percentage of…

Primary: Global Photodamage Severity — 4.8; 5.45 units on a scale

Primary: Overall Wrinkle Improvement Assessed by the Fitzpatrick Wrinkle and Elastosis Scale (FWES) at 12 Weeks Post-Final Treatment — 5.97; 5.78 units on a scale

Primary: Improvement in Facial Wrinkles — 24 Participants

Primary: Difference in Basal Layer Keratinocytes Positive for Both Ki67 and Thymine Dimers — 21.5; 14.7 positive cells/1000 basal layer cells

Primary: Proportion of Participants With Improvement in Periorbital Wrinkles From Baseline — 10; 2; 8; 2 Participants

Primary: Change in Facial Skin Elasticity — 0.7658; 0.7244 ratio