29 closest matches · ranked by relevance
Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)
Primary: Maximal Increase From Baseline in Serum Sodium Concentration Following Tolvaptan Administration. — 3.6; 5.3; 7.9 mmol/L
Syndrome of Inappropriate Antidiuretic Hormone Secretion
Primary: Percentage of Subjects With Normalized Serum Sodium Concentration on the Day After Final IMP Administration — 43.8; 80; 80; 85.7 percentage of participants
Hyponatremia · Syndrome of Inappropriate ADH (SIADH) Secretion
Primary: Change in Sodium Levels From Start of Treatment With Tolvaptan Until Hospital Discharge — 10.3 mmol/L
Hyponatremia · Syndrome of Inappropriate ADH (SIADH) Secretion
Primary: Number of Patients Managed According to the SEOM Algorithm (as a Result Adherence to the Algorithm Will be the % of These Patients Among the Total Number of Patients)…
Hyponatremia
Primary: Participants With Adverse Events (AEs) — 105; 76; 73; 19 participants
Heart Failure
Primary: Median Urine Output at 24 Hours Post Randomization — 2910; 3150 mL
Postural Orthostatic Tachycardia Syndrome
Primary: 24hr Urinary Sodium — 16.8; 280; 14.7; 245 milliequivalents
Heart Failure Acute
Primary: Total Natriuresis After 24 Hours — 409; 345 mmol
Advanced Cancers
Primary: Participants Whose Serum Sodium Concentration Corrected to at Least 135 mEq/L on Day 14 — 16; 1 participants
Congestive Heart Failure
Primary: Change in Natriuresis (Urinary Sodium Excretion) in Control Subjects at 60 Minutes After Volume Expansion Compared to Baseline in Response to Placebo Treatment — 87.19…
Hyponatremia
Primary: Change From Baseline in the Neurocognitive Composite Score of Speed Domains (NCS-SD; Sum of All Correct Speed Domain Z-Scores) — 0.20; 0.39 Z-score — p=0.08
Cushing Disease
Primary: Percentage of Responders With Mean Urinary Free Cortisol (UFC) Within Normal Limits — 22.2 percentage of responders
Traumatic Shock
Primary: Number of Blood Products Transfused — 1.7; 3.0 Litre
Hyponatremia
Primary: Incidence of Hyponatremia (Defined as Serum Sodium Less Than 130 mmol/L) — 1; 2; 8 participants — p=<0.05
Hyponatremia
Primary: Change in Serum Sodium From Baseline to the 48 Hour Assessment or Study Drug Discontinuation. — 126.03; 126.39; 125.55; 130.4 mEq/L — p=0.028
Intracranial Pressure Increase · Abdominal Compartment Syndrome
Primary: Changes in Vasopressin Levels During Pneumoperitoneum and Elevated PEEP — 2.37; 45.48; 54.75; 31.57 pg/ml — p=<0.0001
Hyponatremia · Euvolemia · Hypervolemia
Primary: Number and Severity of Infusion Site Reactions (ISRs) Using a Modified ISR Reporting Scale for Phlebitis and Infiltration in Patients Treated With Dose Regimen 1 and…
Intra-dialytic Hypotension
Primary: Change in Intra-dialytic Decline in Systolic Blood Pressure — 26; 23 mm Hg
Congestive Heart Failure
Primary: Change in Body Weight at 48 Hours — -3.3; -0.8 pounds — p=0.094
Postural Orthostatic Tachycardia Syndrome
Primary: Plasma Volume — 2805; 3032; 2362; 2633 mL
Cushing Syndrome · Endocrine Disease
Primary: Sensitivity of Imaging Modalities for the Detection of ACTH-secreting Non-pituitary Tumor in Patients — 96.3; 77.1; 66.7; 100 percentage of patients
Hypertension
Primary: Number of Participants With First Occurrence of a Myocardial Infarction (MI), Acute Coronary Syndrome (ACS), Stroke, Heart Failure (HF), or CVD Death — 243; 319…
Dumping Syndrome
Primary: Response Rate in Plasma Glucose Level — 60.5 percentage of participants
Hyponatremia
Primary: Hospital Acquired Hyponatremia — 10; 11; 1 participants
Electrolyte Imbalance · Hyponatremia · Hypernatremia
Primary: Sweat Sodium Concentration Obtained After the Steady-state Portion of the Trial — 80.1; 76.8; 84.7 mEq/L
Nephrogenic Diabetes Insipidus
Primary: 24h Urine Volume — 6475; 4178; 6652; 4188 urine volume in mL/d
Polycystic Ovary Syndrome
Primary: Mean Overnight Growth Hormone Levels — 0.85; 0.84 ng/mL — p=0.918
Postural Tachycardia Syndrome
Primary: Alldosterone Increase in Response to Adrenocorticotropin Hormone (ACTH). — 52.5; 57.9 nanograms/dL
Postural Orthostatic Tachycardia Syndrome (POTS)
Primary: Mean Arterial Blood Pressure Change — 14; 10 mmHg