N/A N=1,516 Brain Injury Rehabilitation Improving the Transition Experience
Traumatic Brain Injury
Primary: Participation Assessment With Recombined Tools - Objective 17 (PART-O-17) — 1.30; 1.33 units on a scale — p=0.44
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=122 Brain Tissue Oxygen Monitoring in Traumatic Brain Injury (TBI)
Severe Traumatic Brain Injury
Primary: Fraction of Time That Brain Oxygen Levels Are Below the Critical Threshold of 20 mm Hg . — 0.15; 0.44 Proportion
Phase 2 N=18 Hyperbaric Treatment of Traumatic Brain Injury (TBI)
Traumatic Brain Injury
Primary: Number of Participants With Improved Cerebral Perfusion — 8 Participants
N/A N=6 Team Based Initiative Support
Traumatic Brain Injury
Primary: Number of Participants Who Reported 5 Themes — 6; 6; 6; 6 participants
N/A N=23 Optimizing Cognitive, Environmental, and Neuromotor Stimulation in Traumatic Brain Injury
Traumatic Brain Injury · Dementia Alzheimers · Military Activity
Primary: Change in Executive Functioning as Assessed by the Trail Making Test — -9.2; 24.7 change in seconds — p=.323
N/A N=97 Traumatic Brain Injury (TBI) Screening Instruments
Brain Injury
Primary: Responses From the TBI Clinical Reminder — 61; 88 percentage of participants
N/A N=31 Enhancing the Transition From Hospital to Home for Patients With Traumatic Brain Injury and Families
Brain Injuries, Traumatic · Transitional Care · Family Members
Primary: Change in Quality of Life as Measured by the Short Form-36 (SF-36) — 47.97 score on a scale
N/A N=55 Cognitive-Behavioral Therapy for Veterans With TBI
Insomnia · Traumatic Brain Injury
Primary: Change in Insomnia Severity — 8.833; 7.810; 9.625; 8.364 score on a scale
Phase 3 N=83 TBI Dose De-escalation for Fanconi Anemia
Fanconi Anemia
Primary: Number of Participant With Neutrophil Recovery — 78 Participants
Phase 2 N=50 Treatment of Traumatic Brain Injury With Hyperbaric Oxygen Therapy
Brain Injury, Chronic
Primary: Computer Cognitive Test Scores - ImPACT Verbal Memory — 70.48; 74.21; 78.12; 75.36 units on a scale
N/A N=257 Improving Outcomes for Care Partners of Persons With Traumatic Brain Injury
Caregivers
Primary: Change From Baseline in Self-reported Caregiver Strain as Measured by Traumatic Brain Injury Caregiver Quality of Life (TBI-CareQOL) Caregiver Strain — -1.09; 0.34 T Score
Phase 4 N=15 Anterior Pituitary Hormone Replacement in Traumatic Brain Injury
Growth Hormone Deficiency · Traumatic Brain Injury
Primary: Maximum Oxygen Uptake at Baseline. — 29.0 mL/kg/min
N/A N=39 One-Day Life Skills Workshop for Veterans With TBI, Pain and Psychopathology
Mild Traumatic Brain Injury · Distress-based Psychopathology · Chronic Pain
Primary: World Health Organization-Quality of Life (WHO-QOL) — 6.11; 5.20 units on a scale
N/A N=6 Deep Brain Stimulation for the Treatment of Traumatic Brain Injury
TBI (Traumatic Brain Injury)
Primary: Percent Change in Trail Making Test Part B Time to Completion — -25.6 percent change in time
Phase 2 N=61 A Study of Modified Stem Cells in Traumatic Brain Injury (TBI)
Traumatic Brain Injury
Primary: Change From Baseline in Fugl-Meyer Motor Scale (FMMS) Score at Week 24 Among All Patients — 6.0; 11.0; 8.1; 2.3 Change in score on a scale from baseline — p=0.0401
N/A N=33 rTMS to Improve Cognitive Function in TBI
Traumatic Brain Injury
Primary: Trail Making Test Part B — 52.1; 45.3; 52.9; 50.8 T-score
N/A N=184 Intervention to Promote Survivor Resilience and Adjustment: Efficacy and Sustainability
Traumatic Brain Injury
Primary: Number of Subjects Completing the Two Structured Outpatient Intervention Programs Resilience and Adjustment Intervention (RAI) vs. RAI With Follow-up Booster Sessions…
N/A N=77 Improving Sleep in Veterans With TBI
Traumatic Brain Injury
Primary: Change in Self-reported Pain — 9.8; 10.2; 9.3; 10.0 Score on Pain Interference — p=<0.02
Phase 1 N=52 Behavioral and Neuroimaging Changes After Cognitive Rehab in Traumatic Brain Injuries (TBI) and Mild Cognitive Impairment (MCI)
Mild Cognitive Impairment · Alzheimer's Disease · Traumatic Brain Injury
Primary: Memory Test Accuracy on Trained Stimuli — 53.9; 37.6; 48.9; 37.3 Percent correct
N/A N=108 Brain Training to Enhance Frontal Lobe Reasoning
Traumatic Brain Injury
Primary: Glasgow Outcome Scale-Extended — 6.21; 6.30 units on a scale
N/A N=205 Telephone Tinnitus Education for Patients With Traumatic Brain Injury (TBI)
Tinnitus
Primary: Tinnitus Functional Index — 69.9; 68.2; 47.8; 66.8 units on a scale — p=<.0001
N/A N=91 Executive Functioning in TBI From Rehabilitation to Social Reintegration: COMPASS
Traumatic Brain Injury · Post-Traumatic Stress Disorder
Primary: Change From Baseline in Community Reintegration for Injured Service Members at 2 Months — 40.22; 37.79 score on a scale
N/A N=637 Transforming Research and Clinical Knowledge in TBI Pilot
Traumatic Brain Injury
Primary: Glasgow Outcome Scale Extended (GOSE) — 7; 5 Glasgow Outcome Scale Extended (GOSE)
Phase 1 N=1,236 A Brief Educational Intervention to Improve Traumatic Brain Injury (TBI) Screening Outcomes
TBI
Primary: mTBI Questionnaire — 5.38; 7.52 correct answers out of 10
N/A N=93 Neuroplasticity in TBI and Schizophrenia
Schizophrenia · Traumatic Brain Injury
Primary: Mismatch Negativity (MMN) Amplitudes in Microvolts — -0.59; -1.19; -0.41; -0.65 microvolts
Phase 3 N=34 Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Depression & Other Neuropsychiatric Symptoms After Traumatic Brain Injury (TBI)
TBI Depression
Primary: Average Depression Score Using the Hamilton Depression (HAM-D) 17 Scale — 23.154; 23.076; 13.154; 12.706 units on a scale
Phase 4 N=81 Buspirone for the Treatment of Traumatic Brain Injury (TBI) Irritability and Aggression
Traumatic Brain Injury
Primary: Neuropsychiatric Inventory-Irritability Domain - Observer-rated Proportion Improved ≥ 3 Points Baseline to Day-91 — 30; 31 Participants
N/A N=12 Acute Intermittent Hypoxia in Traumatic Brain Injury
Brain Injuries, Traumatic
Primary: Change in Vitals at Visit 2 — 0 Participants
Phase 2 N=50 Translocator Protein and Inflammation After Traumatic Brain Injury
Traumatic Brain Injury (TBI) · Healthy
Primary: Receptor Binding (Vt) — 2.53; 2.21; 3.21; 3.22 mL/cm^3
Phase 2 N=24 Functional Connectivity as a Biomarker of rTMS
Traumatic Brain Injury
Primary: Functional Connectivity (FC) Changes Between the Left Hippocampus and Left Parietal Cortex — -0.03; 0.13; 0.02; -0.01 Change in z-transformed R-value