N/A N=4,559 CENTER-TBI: Collaborative European NeuroTrauma Effectiveness Research in TBI
Traumatic Brain Injury
Primary: Glasgow Outcome Scale - Extended (GOSE) at 6 Months — 2419; 207; 665; 1547 Participants — p=<0.0001
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=31 The Feasibility of Home-Based Measurement of Circadian Timing for Veterans With TBI and Insomnia
Brain Injuries, Traumatic · Sleep Initiation and Maintenance Disorders
Primary: Number of Participants With Adequate Data for Estimation of Dim Light Melatonin Onset (Self-Collected Saliva) — 7 Participants
N/A N=345 Comparison of Sleep Apnea Assessment Strategies to Maximize TBI Rehabilitation Participation and Outcome
Apnea, Sleep · Brain Injury, Traumatic
Primary: Apnea-Hypopnea Index (AHI) — 24.4 times per hour
N/A N=1,516 Brain Injury Rehabilitation Improving the Transition Experience
Traumatic Brain Injury
Primary: Participation Assessment With Recombined Tools - Objective 17 (PART-O-17) — 1.30; 1.33 units on a scale — p=0.44
N/A N=282 INTRuST Structured Assessment For Evaluation of TBI (SAFE-TBI)
Brain Injuries, Traumatic
Primary: Test-retest Reliability SAFE-TBI — 0.372; 0.504; 0.581 kappa (reliability)
N/A N=1,051 Shock, Whole Blood, and Assessment of TBI S.W.A.T. (LITES TO 2)
Hemorrhagic Shock · Traumatic Brain Injury
Primary: 4 Hour Mortality — 50; 32 Participants
N/A N=479 Smart Phone Application for Postconcussion Symptom Reduction
Concussion
Primary: Neurobehavioral Symptom Inventory — 33; 33 score on a scale
Phase 1 N=1,236 A Brief Educational Intervention to Improve Traumatic Brain Injury (TBI) Screening Outcomes
TBI
Primary: mTBI Questionnaire — 5.38; 7.52 correct answers out of 10
Phase 2 N=50 Translocator Protein and Inflammation After Traumatic Brain Injury
Traumatic Brain Injury (TBI) · Healthy
Primary: Receptor Binding (Vt) — 2.53; 2.21; 3.21; 3.22 mL/cm^3
Phase 2 N=122 Brain Tissue Oxygen Monitoring in Traumatic Brain Injury (TBI)
Severe Traumatic Brain Injury
Primary: Fraction of Time That Brain Oxygen Levels Are Below the Critical Threshold of 20 mm Hg . — 0.15; 0.44 Proportion
N/A N=50 Valproate for Mood Swings and Alcohol Use Following Head Injury
Traumatic Brain Injury (TBI) · Alcoholism
Primary: Severity of Affective Lability Based on Shortened Agitated Behavior Scale — 9.22; 9.39 units on a scale
N/A N=438 Evaluation of VA's Traumatic Brain Injury (TBI) Clinical Reminder and Comprehensive TBI Evaluation (CTBIE)
Traumatic Brain Injury
Primary: Diagnostic Accuracy of the TBI Clinical Reminder Screen (TCRS) — 71; 79; 74; 85 Percentage of participants
Phase 3 N=94 Rivastigmine Patch in Veterans With Cognitive Impairment Following TBI
Traumatic Brain Injury · Cognitive Impairment
Primary: Number of Participants With Demonstrated Improvement From Baseline on the Hopkins Verbal Learning Test-Revised (HVLT-R) Total Recall — 20; 23 Participants
Phase 4 N=23 A Psychophysiologic Study of Weakening Traumatic Combat Memories With Post-Reactivation Propranolol
Posttraumatic Stress Disorder
Primary: Physiological Posterior Probability of Posttraumatic Stress Disorder (PTSD) as Determined From Psychophysiologic Responses During Script-Driven Traumatic Memory…
N/A N=96 Vasopressin Versus Catecholamines for Cerebral Perfusion Pressure Control in Brain Injured Trauma Patients
Traumatic Brain Injury
Primary: Time ICP >20 — 1.7; .9 Hours