Phase 4 N=33 Effects of NOV03 on the Tear Film
Dry Eye Disease (DED)
Primary: Thickness of the Mucus-aqueous Tear Film Layer — 3920.3 nm
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Phase 4 N=19 Tear Lipid Layer Thickness With Emollient Eye Drops
Dry Eye Syndromes
Primary: Change in Tear Lipid Layer Thickness — 4.8; 8.8 nm
Phase 4 N=81 Artificial Tears, Tear Lipids and Tear Film Dynamics
Dry Eye
Primary: Tear Lipid Layer Thickness — 0.72; -7.58; 2.06; 1.41 nm
N/A N=32 Objective Testing of Tear Film Stability
Contact Lens Solutions
Primary: Objective, In-vivo Soft Contact Lens Wettability Index — -1.82; -1.98 wettability index
N/A N=16 Tear Film Break-up Time After Instillation of Artificial Tears
Keratoconjunctivitis Sicca
Primary: Noninvasive Tear Film Break-up Time — 14.67; 7.4 seconds
Phase 4 N=8 Tear Osmolarity Changes After Instilling Isotonic Hyaluronate Artificial Tears
Dry Eye
Primary: Osmolarity Change From Baseline (mOsms/L) as a Function of Time (Minutes) — -0.94; 7.25; 5.31; -4.25 mOsmols/L — p=0.4
N/A N=28 Subjective Comparison of Pre-Lens Tear Film Stability With Daily Disposable Contact Lenses
Myopia · Hyperopia · Refractive Error
Primary: Pre-Lens Non-Invasive Keratograph Break Up Time (PL NIK-BUT) at 8 Hours — 5.28; 3.46; 4.93 seconds
Phase 4 N=31 Lipids of the Human Tear Film and Their Effect on Tear Stability
Blepharitis
Primary: Global Response to Therapy — 16; 41 eyes — p=.001
N/A N=9 Daily Disposable Contact Lens Tear Film Study
Myopia
Primary: Number of Participants With Corrected Visual Acuity of 0.0 or Better — 9; 9; 9; 9 participants
N/A N=29 DAILIES TOTAL1® - Comparative Assessment of Tear Film Evaporation
Refractive Error
Primary: Tear Film Evaporation Rate — 120.88; 105.63 gm^-2 h
Phase 3 N=40 A Two Comparator, Controlled Phase 3 Study in Patients With and Without Evaporative Dry Eye
Dry Eye Syndromes
Primary: Tear Evaporation Rate — 77.7; 67; 75.3 g/m^2*h
N/A N=15 Non-invasive Tear Film Dynamic Measurements in Normal, MGD and ADDE Subjects After Saline Instillation
Aqueous Deficient Dry Eye · Meibomium Gland Dysfunction
Primary: Visual Quality — 0.3; 0.32; 0.19; 0.3 microns
Phase 4 N=21 Comparison of Tear Evaporation Rate With Systane Complete in Dry Eye and Non-Dry Eye
Evaporative Dry Eye
Primary: Tear Evaporation Rate — 1.15; 1.38; 1.26; 1.32 % relative humidity per second — p=0.002
N/A N=20 Tear Film Stability After Instillation of Over-the-Counter (OTC) Artificial Drops
Dry Eye Disease
Primary: Aqueous Tear Evaporation Rate Before and After Use of OTC Artificial Tears — 0.047; 0.049; 0.031; 0.032 (µl/cm2/min)
N/A N=20 The Effect of a New Emulsion in Dry Eye Patients on Tear Layer Aberrometry, Contrast Sensitivity, and Reading Ability
Dry Eye Syndrome
Primary: Contrast Sensitivity — -0.375; -0.169; -0.313; -0.264 arbitrary units
N/A N=91 Evaluation of SYSTANE® BALANCE in Dry Eye Subjects With Lipid Deficiency
Dry Eye Syndrome · Lipid Deficiency
Primary: Mean Bulbar Conjunctival Staining — 0.743; 0.442; 0.531; 0.443 percentage of staining
N/A N=49 The Effect of SYSTANE® BALANCE on Tear Film Break Up Time in Dry Eye Subjects
Dry Eye
Primary: Mean Change From Baseline in NITFBUT at Day 30 — 2.83; 0.66 seconds
N/A N=39 Pre-Lens Tear Film Performance of Silicone Hydrogel Daily Disposable Contact Lenses
Myopia
Primary: Pre-Lens Non-Invasive Tear Break-Up Time (PL-NITBUT) — 13.56; 12.0; 11.86 seconds
Phase 4 N=40 The Effect of BEPREVE 1.5% on Tear Film Osmolarity and Tear Film Lipid Layer
Allergic Conjunctivitis
Primary: Tear Osmolarity — 303; 303 mOsM/L
Phase 4 N=55 Clinical Evaluation of Two Marketed Artificial Tears in Non-contact Lens Wearing Patients
Visual Acuity
Primary: Ocular Comfort — 81.96; 82.49 Units on a scale
N/A N=144 Formula Identification (FID) 114657 in Contact Lens Wearers
Refractive Error
Primary: Mean Pre-lens Tear Lipid Layer Thickness After 2 Hours of Lens Wear on Day 1 — 61.2; 61.5 ICU
N/A N=20 Comparison of Tear Evaporation Rate With DAILIES TOTAL1 and Biotrue ONEday
Evaporative Dry Eye
Primary: Tear Evaporation Rate With Nesofilcon A — 0.81; 0.88; 0.92 % relative humidity per second
N/A N=26 Keratometric Tear Breakup Time and Fluorescein Tear Breakup Time
Dry Eye
Primary: Difference Between Keratometric Tear Break Up Time (KTBUT) and Fluorescein Tear Break Up Time (FTBUT) — 5.95; 5.39 time in seconds — p=0.074
Phase 3 N=38 Evaluation of the Effect of Repeated Usage on the Tear Film Characteristics of an Investigational Eye Drop in Dry Eye Sufferers
Dry Eye Syndrome
Primary: Tear Film Evaporation Rate — 26.0 10^-7g/cm^2/sec
N/A N=10 Controlled Adverse Environment: A Pilot Study to Evaluate Tear Film Stability and Tear Evaporation
Environmental Exposure
Primary: Tear Evaporation Rate — 39.0; 44.8; 30.6; 26.7 Watt/meter^2
N/A N=31 Tear Film Stability of DAILIES® AquaComfort Plus® Contact Lenses vs. MyDay® Daily Disposable Contact Lenses
Refractive Error
Primary: Mean Time Post-blink to 15% Distortion of the Projected Rings After 12 Hours of Lens Wear — 22.84; 22.87 seconds
N/A N=20 Acute Comfort and Blurring Profile Evaluation of Marketed Lubricant Eye Drops
Dry Eye
Primary: Drop Comfort — 0.7; 1.05; 1.84; 1.1 units on a scale
N/A N=45 Tear Film Evaluation of Dailies® AquaComfort Plus® Multifocal and Toric
Refractive Error
Primary: Percentage of Subjects With Wettability Grade of 2 or 3 After 12 Hours of Wear — 55.8; 47.2; 46.5; 49.5 percentage of subjects
N/A N=23 Multicenter Trial Evaluating Quality of Tears Produced by Nasal Neurostimulation
Dry Eye Syndromes
Primary: Fluorescein Tear Clearance With Application
N/A N=39 Meibography and Tear Scan Using the Oculus Keratograph 4
Meibomian Gland Dysfunction
Primary: Meibomium Gland Dropout Score - Evidence of Meibomian Gland Dysfunction (MGD) Confirmed by Meibograhpy Imaging Using the Keratograph 4 Measured on a Subjective Grading…