N/A N=21 Pharmacokinetics of Ketamine in Infants and Children
The Pk of IV Ketamine in Children With Heart Disease
Primary: Total Clearance and Intercompartmental Clearance — 60.0; 70.8 L/h/70kg
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=171 Optimal Dosing of Ketamine for Procedural Sedation and Analgesia in Children
Moderate, Deep Sedation
Primary: Sedation Efficacy — 5.5; 6; 6 units on a scale — p=0.2
Phase 4 N=63 Sub-dissociative Ketamine for the Management of Acute Pediatric Pain
Pain
Primary: Cumulative Narcotic Consumption — 19; 14 Participants
N/A N=111 Study to Find the Dose of Rapidly Administered Ketamine for Brief Painful Procedures in Children
Abscess · Fracture
Primary: Median Effective Dose (ED50) and ED95 of Rapidly Administered Ketamine — 0.7; 0.5; 0.6; 0.9 mg/kg of ketamine dose
Phase 3 N=183 Ketamine Versus Co-administration of Ketamine and Propofol for Procedural Sedation in a Pediatric Emergency Department
Procedural Sedation and Analgesia
Primary: Frequency of Adverse Events — 12; 15; 1; 0 participants
Phase 2 N=62 Adjuvant Low-dose Ketamine in Pediatric Sickle Cell Vaso-occlusive Crisis
Sickle Cell Disease · Vaso-Occlusive Crisis
Primary: Number of Participants With Treatment-Emergent Adverse Events [Safety and Tolerability] — 0; 4; 4; 26 Participants
Phase 2 N=200 Recovery After Total Intravenous Anesthesia With Ketofol Versus Mixture of Ketofol and Lidocaine for Short Pediatric Surgery
Surgical Procedure, Unspecified
Primary: Effect of TIVA With Ketofol and Ketofol Plus Lidocaine on Extubation Time in Children — 240; 120 second
N/A N=30 Pharmacokinetics of Acetaminophen in Pediatric Patients With Congenital Heart Disease
Congenital Heart Disease
Primary: Acetaminophen Serum Concentrations — 19; 17; 13; 13 mcg/mL
Phase 4 N=61 Methadone in Pediatric Anesthesia
Anesthesia
Primary: R-methadone Plasma AUC 0-96hr/Dose — 228; 189; 205; 0 (ng * hr-1 * ml-1 * mg-1 — p=<0.05
Phase 4 N=98 Sub-dissociative Dose Ketamine Dosing Study
Acute Pain
Primary: Change in Pain Score From Baseline to 30 Minutes Post Initiation of Drug Administration — 3.8; 3.5 score on a scale
Phase 4 N=240 Low-dose Ketamine vs Morphine for Vaso-occlusive Crisis in Sicklers
Sickle Cell Crisis · Acute Pain
Primary: Maximal Change in NRS Pain Scores as a Percentage of Baseline NRS Pain Score. — -66.4; -61.3; -81.1; -79.8 percent change from baseline NRS score. — p=0.18
Phase 2 N=87 IN Sub-Dissociative Ketamine vs IN Fentanyl
Bone Fracture
Primary: Primary Outcome: Number of Participants With Minor Side Effects and Significant Adverse Events — 0; 0; 41; 25 Participants
Phase 4 N=80 Nebulized Sub-dissociative Dose Ketamine at Three Different Dosing Regimens for Treating Acute Pain in the Pediatric ED
Pain
Primary: Pain Score Reduction From Baseline — 3.5; 3.2; 3.7 pain score
Phase 1 N=12 Oral Ketamine for Control of Chronic Pain in Children
Chronic Pain
Primary: Number of Participants Tolerating Dose — 3; 3; 3; 1 participants
Phase 2 N=40 Measuring the Amount of Methadone or Morphine in the Blood of Neonates, Infants & Children After Cardiac Surgery.
Pain
Primary: Maximum Concentration of Morphine Including Its Metabolites (Morphine-3-glucuronide and Morphine-6-glucuronide) — 27.55; 225; 22.95 ng/mL
Phase 4 N=62 Intravenous Sub-dissociative Dose Ketamine Injection Versus Infusion for Analgesia in the Emergency Department
Pain
Primary: Side Effects — 21; 25 Participants
Phase 1 N=20 The Pharmacokinetics of Ketorolac Tromethamine Administered Intranasally (IN) for Postoperative Pain in Children Aged 12 Through 17 Years
Postoperative Pain
Primary: Cmax (the Maximum Observed Plasma Concentration) — 1153.9; 1625.3 ng/mL
Phase 4 N=60 Ketamine For Acute Treatment of Pain in Emergency Department
Pain
Primary: Change From Baseline of Pain as Described by Numeric Rating Scale (NRS) [Minimum:0, Maximum 10] at 15 Minutes — 3.5; 6.0 units on a scale
Phase 4 N=80 Effect of Ketamine on Analgesia Post-Cardiac Surgery
Pain, Postoperative
Primary: Quantity of Opioids Used in the First 48 Hours Postoperatively — 10.71; 11.14 mg of Dilaudid
Phase 2 N=52 The Impact of Ketamine on Postoperative Cognitive Dysfunction, Delirium, and Renal Dysfunction
Cognitive Disorders · Delirium · Acute Kidney Injury
Primary: Number of Patients With Postoperative Cognitive Dysfunction — 16; 10 Participants — p=0.23
Phase 4 N=90 Low Dose Ketamine Versus Morphine for Moderate to Severe Pain in the Emergency Department
Pain
Primary: Numeric Rating Scale of Pain — 3.93; 4.07 Units on a scale
N/A N=278 Ketamine for Acute Painful Crisis in Sickle Cell Disease Patients
Sickle Cell Crisis
Primary: Pain Scores — 5.6; 5.7 score on a scale
N/A N=56 The Effect of Preoperative Ketamine on the Emergence Characteristics in Children Undergoing Entropion Surgery
Entropion
Primary: Extubation Time — 756.3; 425.9 seconds
Phase 4 N=150 Comparison of Nebulized Ketamine to Intravenous Sub-Dissociative Dose Ketamine for Pain
Pain
Primary: Change in in Pain Score at 30 Minutes — 4.7; 4.5 score on a scale
Phase 4 N=54 Low Dose Ketamine Study on Opioid Tolerance and Hyperalgesia
Idiopathic Scoliosis · Spondylolisthesis
Primary: Morphine Equivalent Consumption (mg/kg) — 1.3; 1.36; 1.28; 1.275 mg/kg
Phase 2 N=10 Low-Dose Ketamine in Children With ADNP Syndrome
ADNP Syndrome
Primary: Number of Participants With an Adverse Event — 9 Participants
Phase 3 N=160 Ketamine / Propofol Admixture "Ketofol" at Induction in the Critically Ill Against Etomidate: KEEP PACE Trial
Critical Illness
Primary: Mean Arterial Pressure — 82.8; 80.9; 81.7; 77.6 mm Hg — p=0.385
Phase 3 N=51 Ketorolac in Postoperative Infants: Pharmacokinetics and Safety
Postoperative Pain in Infants
Primary: Clearance of S-ketorolac and R+ Ketorolac in 2-6 Month Old Infants Following Surgery — 30.7; 6.5 ml/min
Phase 4 N=271 Randomized Clinical Trial of Propofol, 1:1 and 4:1 Combination of Propofol and Ketamine for Procedural Sedation
Procedural Sedation
Primary: Clinical Interventions During Sedation — 41; 33; 48 Clinical interventions performed
Phase 1 N=75 Safety and Pharmacokinetic (PK) Study of Intravenous (IV) Acetaminophen Administration in Pediatric Inpatients
Pain · Fever
Primary: Single-dose Maximum Plasma Concentration (Cmax) , Micrograms Per Milliliter (µg/mL) Pharmacokinetics of IV Acetaminophen — 40.1; 20.1; 16.7; 19.3 micrograms per…