Phase 2 N=172 Celecoxib After Tonsillectomy
Tonsillectomy
Primary: Difference in Number of Days Requiring Rescue Pain Medication — 5.00; 5.75 Days
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=30 Comparison of Sleep Study Results After Partial Intracapsular Tonsillectomy Versus Total Tonsillectomy
Sleep-disordered Breathing · Obstructive Sleep Apnea
Primary: Median Change in Apnea-hypopnea Index (AHI) — 3.8; 8.0 events per hour of sleep — p=.590
Phase 3 N=120 Pediatric Tonsillectomy Pain Reduction Study
Postoperative Pain
Primary: Total Number of Post-operative Doses of Analgesics. — 12; 12; 14 number of doses
Phase 2 N=688 Postoperative Ibuprofen and the Risk of Bleeding After Tonsillectomy With or Without Adenoidectomy
Tonsillectomy · Adenoidectomy
Primary: Number of Participants With Level 3 Postoperative Hemorrhage — 10; 4 Participants
N/A N=75 Peak(R) vs. Electrocautery in Children Undergoing Tonsillectomy With Adenoidectomy
Sleep Disordered Breathing
Primary: Pain Control Assessed by Validated Pain Scores: Days to Having no Pain Following Surgery — 7.0; 9.0 Days
N/A N=314 Evaluating Perioperative Dexamethasone and the Risk of Bleeding in Tonsillectomy
Post-operative Hemorrhage
Primary: Number of Participants With Post-tonsillectomy Bleeding — 13; 17 participants — p=0.05
N/A N=60 A Study of BiZact™ on Children and Adolescents Undergoing Tonsillectomy
Tonsillectomy
Primary: Intra-operative Blood Loss — 1.7 mL
Phase 3 N=50 Management of Post-Tonsillectomy Pain in Pediatric Patients
Pain, Postoperative · Tonsillar Hypertrophy · Tonsillitis
Primary: Number of Participants With FLACC Pain Scores ≥7 From POD 1 Through POD 3 — 1; 1 participants
N/A N=24 Efficacy and Safety of Irreversible Electroporation for Chronic Symptomatic Tonsillar Hypertrophy Treatment
Tonsillar Hypertrophy
Primary: Change of Tonsil(s) Size at 3 Months Compared to the Baseline. — -1.13; -1.26 Scores on a scale
Phase 2 N=116 Effect of Steroids on Post-tonsillectomy Morbidities
Postoperative Pain · Postoperative Nausea and Vomiting
Primary: Maximum Severity of Post-operative Pain — 37; 26; 13; 21 participants — p=0.033
N/A N=48 A Study of BiZact™ on Adults Undergoing Tonsillectomy
Tonsillectomy
Primary: Pain Assessment Using a Visual Analog Scale (VAS) — 5.4 units on a scale
N/A N=453 Childhood Adenotonsillectomy Study for Children With OSAS
Obstructive Sleep Apnea · Snoring
Primary: Improvements in Attention/Executive Domain Index of the Developmental Neuropsychological Assessment (NEPSY) From Baseline to 7 Months. — 7.1; 5.1 units on a scale — p=0.16
N/A N=58 Comparing Healthcare Utilization Between Adenotonsillectomy Patients With and Without Postoperative Antibiotic Use
Snoring · Strep Throat
Primary: Healthcare Utilization — 5; 16; 5; 8 participants
Phase 4 N=12 Pharmacokinetic Evaluation of EXPAREL in Adults Undergoing Tonsillectomy
Pain
Primary: Maximum Plasma Concentration (Cmax) — 254 ng/mL
Phase 2 N=66 Pediatric Pain Optimization After Tonsillectomy
Obstructive Sleep Apnea · Tonsillitis · Pain, Procedural
Primary: Total Amount of Opioid Medications Administered — 1.5; 0.9; 0.5 morphine mg equivalents/kg — p=0.045
Phase 3 N=137 Decrease Emergence Agitation and Provide Pain Relief for Children Undergoing Tonsillectomy & Adenoidectomy
Obstructive Sleep Apnea
Primary: Emergence Agitation and Pain — 14; 10; 4; 3 units on a scale — p=.001
Phase 3 N=60 Magnesium vs Placebo for Tonsillectomy
Pain
Primary: Postoperative Pain — 30; 45 scores on a scale*minutes
N/A N=36 Preoperative Gabapentin for Post-tonsillectomy Pain in Children
Post Operative Pain Management in Children With Tonsillectomy/Adenoidectomy
Primary: Total Oral Analgesia Consumption — 0.228; 0.224; 0.200; 0.193 cumulative hydrocodone (mg/kg)
N/A N=459 Pediatric Adenotonsillectomy Trial for Snoring
Sleep-Disordered Breathing
Primary: Change From Baseline to 12 Months in Caregiver-reported Behavior Rating Inventory of Executive Function (BRIEF) Global Executive Composite (GEC) T Score — -1.90; -3.08…
N/A N=186 Adenotonsillectomy for Obstructive Sleep-Disordered Breathing in Childhood:The Chania Community Oximetry-Based Study
Sleep Disordered Breathing · Obstructive Sleep Apnea · Snoring
Primary: Change in Number of Subjects Without Oxygenation Abnormalities — 12; 10 Participants — p=0.54
Phase 2 N=17 Celecoxib as a Post-tonsillectomy Pain Medication
Tonsillitis
Primary: Self-reported Pain Score — 5.0; 6.0; 5.1; 6.0 pain score (units on a scale) — p=.674
N/A N=100 Safety Study of Quickclot for Bleeding Control After Adenotonsillectomy
Sleep Apnea, Obstructive
Primary: Total Suction Electrocautery Time Required for Hemostasis Will be Recorded as Seconds — 155.3; 60.9; 94.5 seconds
Early Phase 1 N=188 Hydromorphone vs Fentanyl in Children Undergoing Tonsillectomy Surgery
Obstructive Sleep Apnea · Tonsillitis
Primary: Number of Patients Requiring Rescue Intravenous Opioid — 48; 66 Participants
Phase 4 N=39 EXPAREL® for Pain After Tonsillectomy
Tonsillectomy · Tonsillitis · Post-operative Pain
Primary: Pain Score (Pain Scores on a 0/10 Scale) — 3.07; 4.9; 1.76; 1.42 units on a scale — p=0.043
Phase 3 N=116 Does Montelukast Decrease Post Adenotonsillectomy Pain in Children
Pain
Primary: Postoperative Physician Contacts — 20; 24 participants
Phase 4 N=109 Dexmedetomidine in Pediatric Tonsillectomy
Pediatric Adenotonsillectomy · Post Operative Analgesia
Primary: Amount of Post-Operative Rescue Morphine Required for Analgesia — 45.2; 37.0; 43.3; 36.5 ug/kg
Phase 4 N=84 A Comparison of Postoperative Tramadol Versus Acetaminophen With Codeine in Children Undergoing Tonsillectomy
Tonsillitis · Pain
Primary: Efficacy of Two Different Liquid Pain Medications: Tramadol vs. Codeine/Acetaminophen During the Post-tonsillectomy Recovery Period. — 1.5; 1 days
N/A N=99 Adenotonsillectomy Postoperative Parental Teaching Tool
Tonsillectomy
Primary: Difference in Answers to Pre & Post Teaching Questionnaires — -1; 0; 0 difference in testing scores
Phase 4 N=41 Acetaminophen's Efficacy For Post-operative Pain
Tonsillitis · Airway Obstruction · Difficulty Swallowing
Primary: Total Pain Medication — 1.7; 2.2 mg
N/A N=280 Individualized Analgesia After Adenotonsillectomy
Analgesia
Primary: The Percentage of Patients Requiring at Least One Medical Intervention for Respiratory Events — 16; 29 Participants — p=<0.05