N/A N=120 Clinical Evaluation of Enamel Microhardness Using Tooth Whitening Agents
Dental Atraumatic Restorative Treatment
Primary: Enamel Hardness — 348.4; 351.6; 354.5 Vickers hardness kg f/mm2 — p=0.231
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=90 A Clinical Study Assessing the Effects of a Marketed Dentifrice on Tooth Sensitivity While Undergoing Tooth Bleaching
Dentin Sensitivity
Primary: Visual Analogue Scale (VAS) Scores of the Tooth Sensitivity Questionnaire Collected Through the Study — 33.8; 41.6; 36.9; 31.1 millimeter
Phase 4 N=108 Combined Bleaching Technique: Efficacy and Tooth Sensitivity
Tooth Bleaching · Tooth Sensitivity
Primary: Tooth Sensitivity (TS) — 1; 1; 1; 0 score on a scale
N/A N=160 A Study Assessing the Effects of an Experimental Dentifrice in Maintaining Tooth Color Following Tooth Bleaching
Dentin Sensitivity · Oral Hygiene
Primary: Adjusted Mean VITA Shade Score at 24 Weeks After Tooth Bleaching — 12.00; 12.06 score on a scale — p=0.9141
N/A N=80 Resin Infiltration and Resin Infiltration With Bleaching in Improving the Esthetics for Fluorosis Stains
Caries Infiltration · Fluorosis · Dental Care
Primary: Esthetic Changes — 1.90; 5.50; 5.53; 5.35 score on a scale
N/A N=227 A Clinical Trial to Test the Effect of a Marketed Mouth Rinse on Stain Removal
Tooth Stain
Primary: Lobene Stain Index Composite Score at Day 15 — 2.568; 1.909; 1.575 units on a scale — p=<0.001
N/A N=70 Anti-inflammatory Steroids in the Prevention of Tooth Sensitivity
Inflammation
Primary: Visual Analogic Scale (0-100) for Tooth Sensibility. — 6.31; 11.14 units on a scale
Phase 4 N=160 An Efficacy Study of Stain Control of a 67% Sodium Bicarbonate Containing Toothpaste on Chlorhexidine Tooth Staining
Oral Hygiene
Primary: Modified Lobene Stain Index (MLSI) at Week 6 — 0.97; 1.22 Score on a Scale — p=0.1313
Phase 2 N=247 To Evaluate the Efficacy and Tolerability of Sodium Bicarbonate Toothpaste
Oral Hygiene
Primary: Number of Gingival Bleeding Sites at 24 Weeks — 45.13; 45.84; 18.67; 36.39 number of gingival bleeding sites — p=<0.0001
N/A N=129 Efficacy of Two Sonic Toothbrushes in Reducing Extrinsic Tooth Stain
Tooth Bleaching
Primary: Lobene Stain Index of Stain Intensity Scores 4 Weeks After Toothbrush Use — 0.89; 0.88; 1.13 score on a scale
Phase 3 N=626 The Efficacy of a Toothpaste to Reduce Sensitivity
Dentin Hypersensitivity
Primary: Hypersensitivity Tactile(Yeaple Probe) — 19.81; 13.94 units on a scale — p=0.05
N/A N=79 Clinical Efficacy of a Toothpaste on Hypersensitivity Reduction
Hypersensitivity
Primary: Tooth Hypersensitity to Touch Stimuli (Tactile) — 10.83; 10.63 Units on a scale — p=0.05
N/A N=279 Clinical Study to Investigate the Tooth Stain Removal Efficacy of Two Experimental Toothpastes Compared to a Standard Toothpaste When Used Twice Daily for 8 Weeks
Oral Hygiene
Primary: Change From Baseline in Mean Total Modified Lobene Stain Index (MLSI) Score at Week 8 — -2.33; -2.42; -0.38 score on a scale — p=<0.0001
N/A N=86 Whitening Efficacy of Dentifrice Containing 10% High Cleaning Silica, 0.5% Sodium Phytate and 0.5% Sodium Pyrophosphate
Tooth Bleaching
Primary: Lobene Stain Index of Stain Extent Scores 4 Weeks After Dentifrice Use — 1.35; 1.64 score on a scale
N/A N=375 Test on a New Experimental Mouth Rinse for Relieving Tooth Sensitivity
Dentin Sensitivity
Primary: Percentage of Subjects With Reduction From Baseline by at Least 30% in Mean Cold Air VAS Stimulus Score at Week 4 — 44.6; 69.3 percentage of participants — p=<0.001
N/A N=181 Clinical Evaluation of the Efficacy of a Marketed Dentifrice on Plaque and Gingivitis
Plaque · Gingivitis
Primary: Within-Treatment Whole-Mouth Differences (vs Baseline) - Gingival Efficacy — .230; .155; .3701; .205 units on a scale
Phase 3 N=48 Reducing Bacteria That Cause Tooth Decay
Caries, Dental · Cariostatic Agents
Primary: Microbial Levels — 11; 7; 15; 15 Participants — p=0.35
N/A N=153 A Test on a New Experimental Mouth Rinse for Relieving Tooth Sensitivity
Dentin Sensitivity
Primary: Mean Tactile Sensitivity Score at Week 4 — 11.21; 23.81; 22.07 grams of force — p=<0.001
N/A N=174 Tooth Sensitivity Relief by Two Mouthrinses
Dentin Sensitivity
Primary: Mean Tactile Sensitivity Score at Week 6 — 37.91; 36.77; 30.16 grams — p=0.811
Phase 2 N=246 To Evaluate Efficacy and Tolerability of Sodium Bicarbonate Toothpaste and Its Effect on Opportunistic or Resistant Organisms
Oral Hygiene
Primary: Number of Gingival Bleeding Sites at 24 Weeks — 13.24; 24.90 Number of bleeding sites — p=<0.0001
Phase 3 N=103 Compare the Clinical Efficacy of Prototype Toothpastes.
Gingival Diseases
Primary: Dental Plaque — 2.273; 1.806; 2.041 Units on a scale — p=<0.05
Phase 2 N=123 A Study to Investigate the Stain and Plaque Removal Capability of Two Experimental Potassium Nitrate Dentifrices
Oral Hygiene
Primary: Change From Baseline in Overall Macpherson Modification of the Lobene Stain Index (MLSI) at 8 Weeks. — -0.32; -0.47; -0.38; -0.40 Score on a scale — p=0.6499
N/A N=220 Study to Investigate the Stain Control of Two Stannous Fluoride Dentifrices
Extrinsic Dental Stain · Oral Hygiene
Primary: Overall Modified Lobene Stain Index (MLSI) Mean Score at Week 4 — 1.38; 1.43; 1.42; 1.38 Score on a scale — p=0.2681
Phase 3 N=102 Compare the Clinical Efficacy of Prototype Toothpastes
Dental Plaque
Primary: Plaque Index — 0.91; 0.84; 1.77 Units on a scale — p=0.05
N/A N=38 Fluoride Varnish for Treatment of White Spot Lesions
White Spot Lesions
Primary: DIAGNOdent Readings at Baseline, Three and Six Months - Intergroup Comparison — 5.10; 6.01; 4.08; 5.50 units on a scale — p=0.636
Phase 3 N=113 Clinical Efficacy of a Toothpaste in Providing Relief From the Pain of Dentinal Hypersensitivity
Dentine Hypersensitivity
Primary: Change From Baseline in Evaporative Air Sensitivity Pain Response on a Schiff Sensitivity Scale at Day 14 — -1.20; -0.37 Score on a scale — p=<0.0001
N/A N=25 Exploratory Study on Effect of Whitening Agent With Emulsion Gel in Xerostomic Population
Xerostomia
Primary: Subjective Perception of Mouth Dryness — 6.92; 6.46; 4.21; 3.46 units on a scale — p=.45
N/A N=45 Efficacy of Three Toothpastes Using an in Situ Caries Model
Dental Caries
Primary: Percentage Surface Microhardness Recovery (SMHR) of Phyte (0% 0.425% and 0.85%) at 2 Weeks — 25.53; 26.81; 7.41; 28.88 % SMHR — p=0.7603
N/A N=226 A Study of the Relief of Tooth Sensitivity of an Experimental Mouthrinse Device
Dentin Sensitivity
Primary: Mean Tactile Sensitivity Score at Week 4 — 10.39; 21.83; 18.72 grams of force — p=<0.001
N/A N=153 Study of an Experimental Toothbrush for Treatment and Prevention of Gingivitis
Dental Devices, Home Care
Primary: Whole-mouth Mean Modified Gingival Index (MGI) Score at Day 42 — 1.880; 1.770 Unit on a scale