Phase 4 N=41 Estrogen Dosing in Turner Syndrome: Pharmacology and Metabolism
Turner Syndrome · Hypogonadism · Premature Ovarian Failure
Primary: Change in Weight From Baseline at 12 Months — 1.1; 1.9 kilograms
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N/A N=17 Effect of Growth Hormone on Early Brain Development in Girls With Turner Syndrome
Turner Syndrome
Primary: Total Brain Volume — 18.22; 19.78 percentage change
Phase 4 N=115 Growth Hormone Treatment for the Prevention of Short Stature in Young Girls With Turner Syndrome Before the Age of 4 Years
Turner's Syndrome
Primary: Height SDS at Year 4 — -1.35; -2.44 standard deviation score
Phase 4 N=69 Long-Term Growth and Skeletal Effects of Early Growth Hormone Treatment in Turner Syndrome
Turner Syndrome
Primary: Most Mature Height Standard Deviation Score (SDS) — -1.37; -1.60 standard deviation score
Phase 3 N=154 Somatropin Treatment to Final Height in Turner Syndrome
Turner Syndrome
Primary: Height Standard Deviation Score (SDS) (National Center for Health Statistics [NCHS]), Change From Baseline to Last Measurement, As Randomized Population — 0.09; 0.97…
N/A N=20 Comparison of Transdermal and Oral Estrogens in Adolescent Girls With Ovarian Failure
Ovarian Failure, Premature
Primary: Estradiol — 53; 14; 12 pg/mL
Phase 4 N=318 Predictive Markers in Growth Hormone Deficiency (GHD) and Turner Syndrome (TS) Children Treated With SAIZEN®
Growth Hormone Deficiency · Turner Syndrome
Primary: Change From Baseline in Insulin Like Growth Factor-1 Standard Deviation Score (IGF-1 SDS) at Month 1 — 1.7692; 1.4007 Standard deviation score (SDS) — p=<0.0001
N/A N=48 Study of Psychological and Motor Effects of Testosterone in Adolescents With XXY/Klinefelter Syndrome
Klinefelter Syndrome · XXY Syndrome
Primary: Change From Baseline on the Delis-Kaplan Executive Function System — -0.72; 1.29; 1.28; 0.65 Scaled scores
Phase 4 N=20 Body Composition in Infants With Klinefelter Syndrome and Effects of Testosterone Treatment
Klinefelter Syndrome
Primary: Change in Body Fat Percent Z-score — -0.12; 0.92 score on a scale
Phase 3 N=175 Efficacy Assessment of Systematic Treatment With Folinic Acid and Thyroid Hormone on Psychomotor Development of Down Syndrome Young Children
Down Syndrome
Primary: GMDS (Griffiths Mental Development Scale) — 51.96; 51.27; 51.66; 51.67 developpement quotient