Phase 4 N=434 Comparative Infection Rates for the Codman BACTISEAL TM External Ventricular Drainage (EVD) System
Intraventricular Hemorrhage · Subarachnoid Hemorrhage
Primary: Number of Infections — 4; 5; 4; 5 Infections
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=433 A Registry for Comparing Catheter-Related Infection Rates Among Various Shunt Systems in the Treatment of Hydrocephalus
Hydrocephalus
Primary: Number of Subjects With Shunt Infections — 14 participants
N/A N=5 Quantitative Characterization of Safe Irrigation for Ventricular Shunt Catheters
Hydrocephaly
Primary: To Demonstrate That the Flusher Can be Primed, Connected, and Activated in a Sterile Clinical Setting Per the Instructions for Use by the Treating Investigator . — 4; 4…
N/A N=64 Treatment of Peritonitis in Automated Peritoneal Dialysis
Secondary Peritonitis
Primary: Peritonitis Resolved — 26; 29 participants — p=<0.05
N/A N=198 Prevention of Neurosurgical Wound Infections
Surgical Wound Infections
Primary: Incidence of Infection That Requires Removal of the Neurosurgical Device — 97; 98 Participants
N/A N=117 External Ventricular Drainage Post-Market Clinical Follow-up Registry
Cerebrospinal; Disorder
Primary: Anticipated Drainage of Cerebrospinal Fluid (CSF) — 116 Participants
N/A N=80 Vancomycin Plus Moxifloxacin Versus Vancomycin Plus Ceftazidime for the Treatment of Peritoneal Dialysis (PD)-Related Peritonitis
Peritoneal Dialysis Associated Peritonitis
Primary: Complete Cure Rate — 32; 31 Participants
N/A N=37 Ventriculostomies in SAH: ICP Open or Not?
Subarachnoid Hemorrhage
Primary: Cerebral Artery Vasospasm — 16; 7 Participants
Phase 2 N=100 Dilute Povidone-iodine Irrigation vs No Irrigation for Children With Acute, Perforated Appendicitis
Acute, Perforated Appendicitis
Primary: Number of Participants With Postoperative Intra-abdominal Abscess — 6; 8 Participants
Phase 2 N=10 Pharmacokinetics of Ceftolozane/Tazobactam in Plasma and Cerebrospinal Fluid
Pharmacokinetics
Primary: Unbound Ceftolozane Exposure in the Plasma — 322.6 mg*h/L
Phase 2 N=52 Clinical Trial on Treatment of Intraventricular Hemorrhage
Intraventricular Hemorrhage
Primary: 30-day Mortality — 1; 1; 6 Number of participants
Phase 4 N=242 Primary Tube Versus Trabeculectomy Study
Glaucoma
Primary: Number of Participants With Surgical Failure — 31; 23; 18; 9 Participants
Phase 1 N=4 Vancomycin Pharmacokinetics in Patients on Peritoneal Dialysis
Peritoneal Dialysis-associated Peritonitis
Primary: Maximum Total Plasma Concentration (Cmax) — 28.7 mg/L
N/A N=555 Comparison of Two Types of Shunts in Infants With Single Ventricle Defect Undergoing Staged Reconstruction--Pediatric Heart Network
Heart Defects, Congenital
Primary: Proportion of Patients Who Died or Received a Heart Transplant — 100; 72 Participants — p=0.013
Phase 2 N=32 Antibiotic Instillation in Appendicitis
Complicated Appendicitis · Acute Appendicitis
Primary: Feasibility of the Use of Antibiotic Solution Instillation Following Intraoperative Diagnosis of Complex Appendicitis as Assessed by Percentage of Eligible Participants…
Phase 4 N=10 Evaluation of Intravenous and Intraperitoneal Pharmacokinetics of Dalbavancin in Peritoneal Dialysis Patients
Infectious Peritonitis
Primary: Determine Dalbavancin Plasma Area Under the Curve in Peritoneal Dialysis Patients After Intravenous and Intraperitoneal Administration — 40573.2; 13532.3 mg*h/L
N/A N=41 Wound Vac Bandage Comparison After Spinal Fusion
Neuromuscular Scoliosis
Primary: Number of Participants With Wound Dehiscence or Infection — 0; 0 Participants
N/A N=141 Assessment of CSF Shunt Flow With Thermal Measurements B
Hydrocephalus
Primary: Study Device Sensitivity — 88.9 percent of ground truth positive cases
Phase 3 N=1,103 Topical Vancomycin for Neurosurgery Wound Prophylaxis
Infection · Surgery · Nervous System Diseases
Primary: Any Surgical-site Infection as Evidenced by Surgeon or Attending Physician Diagnosis, or Signs and Symptoms of Infection Assessed by Phone Call Interview or at In-office…
N/A N=83 Repair of Infected or Contaminated Hernias
Hernia
Primary: Incidence of Wound Events — 53 participants
N/A N=44 Assessment of CSF Shunt Flow With Thermal Measurements A
Hydrocephalus
Primary: Study Device Sensitivity — 88 percent
N/A N=671 Prevention of Peritonitis in Peritoneal Dialysis
Kidney Failure, Chronic · Peritoneal Dialysis-associated Peritonitis · Dialysis Capd Infection
Primary: Time to the First Dialysis-associated Peritonitis Episode in the Retraining Group and the Control Group — 381; 368 Days to first peritonitis episode — p=0.51
N/A N=130 A Study on the Safety of Hakim Programmable Shunt System
Hydrocephalus
Primary: Number of Participants With Non-infection Within One Year — 5 Participants
N/A N=190 Antibiotic Irrigation for Pancreatoduodenectomy
Surgery · Infection
Primary: The Number of Patients With Infections — 11; 10 Participants
Phase 3 N=250 Reducing INfection at the Surgical SitE With Antibiotic Irrigation During Ventral Hernia Repair (RINSE Trial)
Ventral Hernia Repair
Primary: Surgical Site Infection — 11; 10 Participants
N/A N=102 Intravenous Versus Intravenous/Oral Antibiotics for Perforated Appendicitis
Perforated Appendicitis
Primary: Abscess After Appendectomy — 10; 10 number of patients
N/A N=25 Catheter Placement for Hepatic Hydrothorax
Pleural Effusion
Primary: Feasibility of Using Indwelling Tunneled Pleural Catheters for the Management of Hepatic Hydrothorax — 25 Participants
Phase 3 N=1,010 Perioperative Antibiotic Therapy to Prevent Cardiac Implantable Electronic Device Infections.
Sick Sinus Syndrome · Complete Heart Block · Syncope
Primary: Number of Patients With a Major Cardiac Implantable Electronic Devices (CIED) Infection — 5; 6 Participants
N/A N=82 Role of Intravenous Versus Home Oral Antibiotics in Perforated Appendicitis
Perforated Appendicitis
Primary: Number of Participants With Postoperative Abscess — 5; 3 Participants — p=0.7188
Phase 3 N=607 Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR)
Vesicoureteral Reflux · Urinary Tract Infections
Primary: Recurrent Febrile or Symptomatic Urinary Tract Infection During 2-year Follow-up — 39; 72 participants — p=<0.001