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Pre-stenting increases FANS-UAS placement success from 80.0% to 94.8% in RIRS for kidney stonesPre-stenting improves success rates for kidney stone surgery

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Key Takeaway
Note that pre-stenting significantly improves FANS-UAS placement success and reduces stone access time during RIRS.

This randomized controlled trial enrolled 221 patients undergoing retrograde intrarenal surgery (RIRS) for kidney stones. Patients were divided into three groups based on pre-stenting duration: Group 1 (no pre-stenting), Group 2 (2-4 weeks), and Group 3 (4-6 weeks). The primary outcome was successful FANS-UAS placement.

Successful FANS-UAS placement increased from 80.0% in Group 1 to 93.2% in Group 2 and 94.8% in Group 3 (p = 0.006). Multivariable logistic regression identified pre-stenting as the only independent predictor of success, with adjusted ORs of 3.47 (95% CI 1.14-10.59, p = 0.029) for Group 2 and 5.31 (95% CI 1.60-17.68, p = 0.006) for Group 3 compared to Group 1. Additionally, stone access time was markedly shorter in pre-stented groups (p < 0.001).

Secondary outcomes, including successful RIRS (87.1% vs 94.6% vs 94.8%, p = 0.146), stone-free rates (84.3% vs 87.8% vs 88.3%, p = 0.672), and secondary procedure rates (17.1% vs 12.2% vs 7.8%, p = 0.224), did not show statistically significant differences between groups.

Safety data indicated that clinically significant complications (Grade 3 or higher) were similar across all groups (12.9%, 12.2%, and 7.8%, p = 0.558). No significant difference was found between 2-4 weeks and 4-6 weeks of pre-stenting. Pre-stenting is associated with improved technical success and facilitated ureteral access during RIRS.

When a patient has a kidney stone, the surgery to remove it can be complicated by difficult access to the stone. Doctors often use a special tool called a FANS-UAS to help during the procedure. This study looked at how the timing of a pre-placed stent—a small tube used to keep the path open—affected the success of placing that tool.

Researchers tracked 221 patients undergoing surgery. They compared three groups: those with no pre-stenting, those with a stent for 2 to 4 weeks, and those with a stent for 4 to 6 weeks. The results showed that patients with a pre-placed stent had a much higher success rate for placing the FANS-UAS tool. Specifically, success jumped from 80% in the no-stent group to over 93% in the groups that had a stent for at least two weeks.

While the timing between 2 and 6 weeks did not show a major difference in success, the presence of a stent did make the surgery faster by shortening the time needed to reach the stone. Importantly, the study found that the amount of pre-stenting did not increase the risk of serious complications. This suggests that pre-stenting is a reliable way to help surgeons navigate the anatomy more effectively during kidney stone removal.

What this means for you:
Pre-stenting before surgery significantly improves the success rate of placing tools to treat kidney stones.

Common questions

Does a pre-placed stent make the surgery safer?

The study found that patients in all groups had similar rates of serious complications. Specifically, the rates were 12.9%, 12.2%, and 7.8% for the three different groups. This suggests that while the stent helps the surgeon reach the stone, it does not increase the risk of major complications.

How does pre-stenting help the surgery process?

Pre-stenting makes it much easier for doctors to reach the stone. The study found that the time needed to access the stone was markedly shorter for patients who had a stent placed before their surgery compared to those who did not have one.

Does the length of time the stent is in place matter?

The study found that both the 2 to 4 week and 4 to 6 week pre-stenting groups had higher success rates for tool placement than the no-stent group. However, there was no significant difference in success between the 2 to 4 week and 4 to 6 week groups.

Study Details

Study typeRct
Sample sizen = 221
EvidenceLevel 2
Follow-up0.9 mo
PublishedAug 2026
View Original Abstract ↓
PURPOSE: To evaluate the impact of pre-stenting duration on flexible and navigable ureteral access sheaths (FANS-UAS) placement, as well as perioperative and postoperative outcomes, in patients undergoing retrograde intrarenal surgery (RIRS). METHODS: A total of 221 patients were prospectively randomized into three groups: no pre-stenting (Group 1, n = 70), pre-stenting for 2-4 weeks (Group 2, n = 74), and pre-stenting for 4-6 weeks (Group 3, n = 77). Analyses were performed according to the intention-to-treat principle. The primary outcome was successful FANS-UAS placement. Secondary outcomes included successful RIRS, stone-free rate (SFR), stone-related secondary procedures, perioperative parameters, and postoperative complications. Post hoc pairwise comparisons and multivariable logistic regression analyses were performed to identify factors associated with FANS-UAS placement success. RESULTS: FANS-UAS placement success differed significantly among the groups, increasing from 80.0% in Group 1 to 93.2% and 94.8% in Groups 2 and 3, respectively (p = 0.006). Stone access time was markedly shorter in the pre-stented groups (p < 0.001). Successful RIRS (87.1%, 94.6%, and 94.8%; p = 0.146), SFR (84.3%, 87.8%, and 88.3%; p = 0.672), and secondary procedure rates (17.1%, 12.2%, and 7.8%; p = 0.224) were comparable among the groups. Post hoc analysis demonstrated meaningfully higher FANS-UAS placement success in pre-stented patients compared with non-stented patients, whereas no difference was observed between 2 and 4 and 4-6 weeks of pre-stenting. In multivariable logistic regression analysis, pre-stenting remained the only independent predictor of successful FANS-UAS placement (Group 2 vs. Group 1: adjusted OR 3.47, 95% CI 1.14-10.59, p = 0.029; Group 3 vs. Group 1: adjusted OR 5.31, 95% CI 1.60-17.68, p = 0.006). Clinically significant complications (≥ Grade III) were similar among the groups (12.9%, 12.2%, and 7.8%; p = 0.558). CONCLUSIONS: Pre-stenting was independently associated with improved FANS-UAS placement success and facilitated ureteral access during RIRS. No statistically significant differences were detected between patients who underwent 2-4 weeks and those who underwent 4-6 weeks of pre-stenting.
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