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Home › Conditions › Nephrolithiasis

Nephrolithiasis

Part of Kidney Diseases

15 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Nephrolithiasis

18 trials tracked for Nephrolithiasis: 7 in phase 3 or 4 and 1 with published results. The most-cited published study has 137 citations.

18Trials tracked
7Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 4 Phase 3 3 Phase 2 3 Other / NA 8
  1. Phase 3 Hydrochlorothiazide for Kidney Stone Recurrence Prevention Completed · 137 cited
  2. Phase 4 A Randomized Trial of Preoperative Prophylactic Antibiotics Prior to Kidney Stone Surgery (Percutaneous Nephrolithotomy [PCNL]) Completed
  3. Phase 4 The Use of Belladonna and Opium Suppository in the Treatment of Postoperative Stent Pain Completed
  4. Phase 4 Narcotic-Free Percutaneous Nephrolithotomy Completed
  5. Phase 4 Vitamin D Repletion in Stone Formers With Hypercalciuria Completed
  6. Phase 3 Perioperative Pregabalin in Ureteroscopy: a Pilot Completed
Show 12 more trials
  1. Phase 3 Pain Outcomes of Non-opioid vs. Opioid Analgesia for Kidney Stone Surgery. Completed
  2. Phase 2 Effect of Antihistamines on Ureteral Stent-Related Symptoms Completed
  3. Phase 2 Use of Oral Probiotics to Reduce Urinary Oxalate Excretion Completed
  4. Phase 2 Evaluating ALLN-177 for Reducing Urinary Oxalate Excretion in Calcium Oxalate Kidney Stone Formers With Hyperoxaluria Completed
  5. N/A Noninvasive Electrical Stimulator as a Pain Control Treatment Post-ureteroscopy Completed
  6. N/A Trial Assessing Renal Damage During Ureteroscopy Completed
  7. N/A Intraoperative Cone-beam CT for Percutaneous Nephrolithotomy Completed
  8. N/A Evaluation of a Nonopioid Recovery Pathway Following Surgery for Kidney Stones Completed
  9. N/A A Pilot Study of Oxalate Absorption in Secondary Hyperoxaluria Completed
  10. N/A A Comparison of Ureteroscopic Treatment of Nephrolithiasis With and Without Moses Technology Completed
  11. N/A Thulium vs. Hol:YAG Laser Completed
  12. N/A Impact Ureteral Sheath Design During Ureteroscopy Completed

Showing the 18 most-cited and recently-updated of 18 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Nephrolithiasis: what the trials found

Management of nephrolithiasis includes various pharmacological and procedural interventions. Oxycodone (5mg) was evaluated for pain management, with associated Visual Analog Scale (VAS) scores recorded at 4.5, 5, 1, and 1 1. Ketorolac oral tablets were also studied; while no significant difference was found in satisfaction with pain relief or current pain intensity, a statistically significant difference was observed in peak pain intensity levels (p=0.006) 6.

Procedural interventions for the condition include the use of Thulium Fibre Laser [11, 15]. Other investigated treatments include Ergocalciferol 4, Pregabalin (300mg) 7, and nitrofurantoin monohydrate/macrocrystalline capsules, which were associated with varying grades of postoperative complications on the Clavien-Dindo scale 3.

Historical or alternative pharmacological combinations such as Belladonna and Opium were evaluated in relation to global quality of life scores on postoperative days 1 and 3 2.

Recent results — preliminary, needs further review

  • Fexofenadine Hcl (180mg) was studied for urinary symptoms and body pain, showing specific score changes in a Phase 2 trial 8.

For the clinician treating this condition

  • Ketorolac shows significant impact on peak pain intensity levels compared to control groups, though current pain intensity scores may not differ significantly 6.
  • Thulium Fibre Laser is an established procedural intervention for the management of nephrolithiasis [11, 15].
  • Pharmacological options range from opioids like Oxycodone 1 and Pregabalin 7 to non-opioid options such as Ketorolac 6 or nitrofurantoin 3.

AI synthesis of 7 cited trials, updated Jun 26, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Mini-PCNL and standard PCNL show comparable stone-free rates in pediatric patients with nephrolithiasis
Pediatrics Meta-analysis
Mini-PCNL and standard PCNL show comparable stone-free rates in pediatric patients with nephrolithiasis Mini-PCNL and Standard PCNL Show Similar Success for Kidney Stones
This meta-analysis of 490 pediatric patients compared mini-PCNL to standard PCNL for nephrolithiasis. The analysis found comparable stone-fr…
Mini-PCNL and standard PCNL procedures show similar success rates for removing kidney stones in children, despite differences in surgery tim…
Sep 26, 2026
Establishment of expected 24-hour urine ranges in healthy adults without kidney stone disease
Urology Meta-analysis
Establishment of expected 24-hour urine ranges in healthy adults without kidney stone disease New data establishes expected ranges for 24-hour urine tests
Researchers established expected ranges for various 24-hour urine components in healthy adults without kidney stone disease. While several d…
New data provides clear expected ranges for 24-hour urine tests, helping clarify what is considered normal for people without kidney stones.
medRxiv Sep 20, 2026
Liraglutide may protect against nephrolithiasis in metabolic syndrome via mitochondrial and lipid pathways
Drug Pipeline Sys. Review
Liraglutide may protect against nephrolithiasis in metabolic syndrome via mitochondrial and lipid pathways Liraglutide May Help Prevent Kidney Stones in Metabolic Syndrome
This systematic review synthesizes preclinical and clinical evidence on liraglutide's renal effects in metabolic syndrome, proposing mitocho…
A review suggests liraglutide might protect against kidney stones by calming inflammation and oxidative stress in kidney cells.
Frontiers Sep 14, 2026
Pre-stenting increases FANS-UAS placement success from 80.0% to 94.8% in RIRS for kidney stones
Urology RCT
Pre-stenting increases FANS-UAS placement success from 80.0% to 94.8% in RIRS for kidney stones Pre-stenting improves success rates for kidney stone surgery
This randomized controlled trial of 221 patients undergoing retrograde intrarenal surgery found that pre-stenting significantly improved FAN…
A new study shows that placing a stent before kidney stone surgery can make it easier for doctors to access stones and place necessary tools…
Sep 6, 2026
PDI therapy increases stone-free rates for lower pole stones following ESWL or RIRS
Urology Meta-analysis
PDI therapy increases stone-free rates for lower pole stones following ESWL or RIRS PDI Therapy Linked to Higher Stone Clearance After Kidney Surgery
This meta-analysis of randomized controlled trials evaluated the impact of percussion, diuresis, and inversion (PDI) on patients with lower …
A review of clinical trials suggests that PDI therapy may help patients clear more kidney stones after certain types of surgery.
Aug 17, 2026
Suction-assisted PCNL maintains lower intrarenal pressure and improves perioperative outcomes compared to conventional PCNL
Urology Meta-analysis
Suction-assisted PCNL maintains lower intrarenal pressure and improves perioperative outcomes compared to conventional PCNL Suction Assisted Surgery May Lower Pressure During Kidney Stone Removal
This meta-analysis of 1,171 patients evaluates suction-assisted versus conventional percutaneous nephrolithotomy (PCNL) for nephrolithiasis.…
A new analysis suggests that using suction during kidney stone surgery can lower internal pressure and reduce complications like fever and s…
Jul 5, 2026
Omission of postoperative double-J stents after uncomplicated URS reduces pain and analgesic requirements
Urology Meta-analysis
Omission of postoperative double-J stents after uncomplicated URS reduces pain and analgesic requirements Skipping Stents After Kidney Stone Surgery Reduces Patient Pain
This meta-analysis of randomized trials involving 3572 adults with ureteral and renal stones found that omitting double-J stents after uncom…
Patients undergoing ureteroscopy for kidney stones may experience less pain and fewer complications if a double-J stent is not used after su…
Jun 15, 2026
Active stone-directed intervention reduces odds of composite recurrence and surgery for asymptomatic kidney stones
Urology Meta-analysis
Active stone-directed intervention reduces odds of composite recurrence and surgery for asymptomatic kidney stones Active Intervention Reduces Surgery for Patients with Kidney Stones
This meta-analysis of 592 patients found that active stone-directed intervention significantly reduced the odds of composite recurrence (OR …
Active treatment for asymptomatic kidney stones may lower the risk of future surgeries and stone growth while maintaining a similar safety p…
Jun 15, 2026
ECIRS triples stone-free odds versus PCNL in large kidney stones, meta-analysis finds
Urology Meta-analysis
ECIRS triples stone-free odds versus PCNL in large kidney stones, meta-analysis finds New surgery clears kidney stones better than the standard method without more risk
This systematic review and meta-analysis of 1988 patients with high stone burden found that endoscopic combined intrarenal surgery (ECIRS) s…
A new analysis shows a specific surgery clears kidney stones faster and with fewer complications than the standard approach for tough cases.
Jun 1, 2026
Meta-analysis of RCTs shows mPCNL yields higher single-session stone-free rates than RIRS for medium renal stones
Urology Meta-analysis
Meta-analysis of RCTs shows mPCNL yields higher single-session stone-free rates than RIRS for medium renal stones Mini-PCNL clears kidney stones better than RIRS in one session
This meta-analysis of randomized controlled trials evaluated retrograde intrarenal surgery versus miniaturized percutaneous nephrolithotomy …
Mini-PCNL clears medium-sized kidney stones in one session more often than RIRS, but RIRS has fewer complications and shorter hospital stays…
May 24, 2026
Complication risks in elderly patients undergoing percutaneous nephrolithotomy compared to younger populations
Urology Meta-analysis
Complication risks in elderly patients undergoing percutaneous nephrolithotomy compared to younger populations Older patients can safely undergo kidney stone surgery with careful care
This systematic review and meta-analysis of 45,603 patients investigated complication rates and stone-free rates in elderly versus non-elder…
New research shows older adults can safely have kidney stone surgery, though infection risks rise with age.
May 7, 2026
RIRS with TFLLT shows similar stone-free rates to PNL for 20-30 mm kidney stones in adults
Urology RCT
RIRS with TFLLT shows similar stone-free rates to PNL for 20-30 mm kidney stones in adults Small kidney stones get cleared with less pain and blood loss now
This randomized prospective study compared Retrograde Intrarenal Surgery (RIRS) with Thulium Fiber Laser Lithotripsy (TFLLT) to Percutaneous…
A new laser technique clears large kidney stones with less pain and blood loss while keeping success rates high for patients
May 1, 2026

Questions about Nephrolithiasis

What renal complications might occur in patients with inflammatory bowel disease?

Patients with inflammatory bowel disease face specific kidney risks including chronic kidney disease, glomerulonephritis, and nephrolithiasis, with some stones directly linked to medications like mesalazine.

Full answer →
Do people with inflammatory bowel disease have higher risks of kidney stones?

People with inflammatory bowel disease, especially Crohn's disease, have a higher risk of kidney stones due to malabsorption and chronic inflammation.

Full answer →

All Nephrolithiasis Articles