Peri- and postmenopausal hormonal changes may exacerbate asthma, rhinitis, cough, allergies, hypersensitivity, anaphylaxis, and angioedema.

This systematic review evaluates the relationship between menopause, characterized by declining and fluctuating estrogen and progesterone levels, and a spectrum of allergic and inflammatory conditions. The conditions under review include asthma, allergic rhinitis, chronic cough, skin allergies, drug hypersensitivity, anaphylaxis, and angioedema within a population of peri- and postmenopausal women. The review notes that sample size and specific setting details were not reported in the available data.

The primary finding relies on clinical observations suggesting that the hormonal shifts of menopause may exacerbate existing conditions or trigger new-onset disease. However, the review explicitly states that specific main results and numerical data regarding the magnitude of these effects were not reported in the input evidence. Consequently, no exact numbers or statistical significance can be provided for these outcomes.

Safety and tolerability data, including adverse events, serious adverse events, discontinuations, and overall tolerability, were not reported. The review highlights that the mechanistic understanding of these interactions remains limited. Furthermore, evidence-based guidelines for the diagnosis, management, and individualized therapy in this specific population are currently scarce.

Key limitations include the lack of mechanistic clarity and the scarcity of robust guidelines for managing these conditions in peri- and postmenopausal women. Practice relevance dictates that clinicians must integrate the patient's menopausal status into their assessment and management strategies. Due to the uncertainty and limited nature of the current evidence, definitive causal conclusions cannot be drawn, and clinical decisions should be made conservatively.