Phase 2 RCT of IV CN-105 in older adults undergoing noncardiac surgery shows fewer grade 2+ adverse events versus placebo.
Could a simple IV drug help older adults avoid confusion after surgery?
This Phase 2 randomized clinical trial enrolled 203 older adults (60 years or older) scheduled for noncardiac or nonintracranial surgery. Pa…
A new IV drug given before surgery reduced confusion and side effects in older adults, though more testing is needed to confirm it truly pre…
Review of ISG15 pathway targeting for inflammatory and cardiovascular diseases
A Tiny Protein That Fuels Your Inflammation
This narrative review examines the potential of targeting the ISG15 pathway to treat inflammatory diseases, including skin, cardiovascular, …
Understanding this protein could lead to better medicines for skin, heart, and brain diseases.
Lysine lactylation links metabolism to neuroinflammation via chromatin and protein modification
Review explores how a metabolic process may influence brain inflammation
A systematic review synthesizes emerging evidence that lysine lactylation (Kla) couples glycolytic state to chromatin remodeling and protein…
A metabolic process adding lactate to proteins may signal how brain cells respond to inflammation and stress in injury or disease.
Review suggests TWEAK-Fn14 axis contributes to brain injury and cardiac dysfunction pathology
Review explores protein link between brain and heart diseases
A systematic review summarizes evidence on the TWEAK-Fn14 signaling pathway in cardio-cerebrovascular diseases. The review reports that TWEA…
High levels of two specific proteins linked to brain swelling and heart scarring may offer a future target for treating brain-heart syndrome…