Acupuncture promotes microglial transition from pro-inflammatory glycolysis to anti-inflammatory oxidative phosphorylation metabolism
Acupuncture May Tame Brain Inflammation by Changing Energy Use
This systematic review explores the mechanisms of acupuncture in neuroinflammation, specifically focusing on microglial glucose metabolism r…
Acupuncture may calm brain inflammation by shifting immune cells from a pro-inflammatory to an anti-inflammatory state.
Luteolin suppresses neuroinflammation by modulating microglial activation and antioxidant defenses
Luteolin Shows Promise for Brain Inflammation
This systematic review examines luteolin's effects on neuroinflammation in central nervous system disorders. The evidence suggests luteolin …
A compound in celery and parsley may help calm brain inflammation, but more research is needed.
Phase 2 RCT of IV CN-105 in older adults undergoing noncardiac surgery shows fewer grade 2+ adverse events versus placebo
Could a simple IV drug help older adults avoid confusion after surgery?
This Phase 2 randomized clinical trial enrolled 203 older adults (60 years or older) scheduled for noncardiac or nonintracranial surgery.
A new IV drug given before surgery reduced confusion and side effects in older adults, though more testing is needed to confirm it truly pre…
Review of ISG15 pathway targeting for inflammatory and cardiovascular diseases
A Tiny Protein That Fuels Your Inflammation
This narrative review examines the potential of targeting the ISG15 pathway to treat inflammatory diseases, including skin, cardiovascular, …
Understanding this protein could lead to better medicines for skin, heart, and brain diseases.
Dietary restriction may influence neuroinflammation in neurodegenerative and neurological disorders
Eating Less May Protect Your Brain From Inflammation
This narrative review examines the potential of dietary restriction (DR) involving chronic or intermittent calorie or nutrient reduction wit…
Decades of research now suggest that how much — and how often — you eat may directly influence the inflammation driving diseases like Alzhei…
Lysine lactylation links metabolism to neuroinflammation via chromatin and protein modification
Review explores how a metabolic process may influence brain inflammation
A systematic review synthesizes emerging evidence that lysine lactylation (Kla) couples glycolytic state to chromatin remodeling and protein…
A metabolic process adding lactate to proteins may signal how brain cells respond to inflammation and stress in injury or disease.
Review suggests TWEAK-Fn14 axis contributes to brain injury and cardiac dysfunction pathology
Review explores protein link between brain and heart diseases
A systematic review summarizes evidence on the TWEAK-Fn14 signaling pathway in cardio-cerebrovascular diseases.
High levels of two specific proteins linked to brain swelling and heart scarring may offer a future target for treating brain-heart syndrome…
Questions about Neuroinflammation
Will taking CN-105 reduce serious adverse events during my upcoming noncardiac operation?
A 2024 trial found that taking CN-105 before noncardiac surgery reduced serious adverse events in older adults compared to a placebo.
Full answer →Does the TWEAK-Fn14 axis cause brain injury and heart problems in patients?
Research indicates that high levels of the TWEAK-Fn14 axis are linked to brain injury and heart problems, making it a target for treating brain-heart syndrome.
Full answer →