ACIP Recommends JYNNEOS Vaccine for Occupational Orthopoxvirus Exposure Risk

This is a recommendation report from the Advisory Committee on Immunization Practices (ACIP) regarding the use of the JYNNEOS vaccine for persons at risk of occupational exposure to orthopoxviruses, including smallpox, monkeypox, and cowpox, in the United States. The document recommends JYNNEOS (Smallpox and Monkeypox Vaccine, Live, Nonreplicating) for preexposure vaccination in this population. The ACIP issued this recommendation in 2021.

No study results, efficacy data, or safety outcomes are reported within this document. The report does not provide information on adverse events, serious adverse events, discontinuations, or tolerability. Sample size, follow-up duration, and comparator groups are not applicable as this is not a research study.

Key limitations stem from the document's nature as a recommendation rather than an evidence-generating study. It does not present new clinical trial or observational data to support the recommendation's underlying evidence base. Funding sources and potential conflicts of interest are not reported.

For clinical practice, this report signals official ACIP guidance for considering preexposure vaccination with JYNNEOS in specific occupational settings. Healthcare providers managing workers at risk for orthopoxvirus exposure should consult the complete ACIP recommendations and relevant clinical guidelines for detailed implementation criteria, which are not specified in this summary.