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Multivessel coronary endarterectomy increases 30-day mortality and perioperative myocardial infarction compared to single-vesselMultivessel coronary endarterectomy increases risk for heart surgery patients

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Key Takeaway
Note that multivessel coronary endarterectomy significantly increases 30-day mortality and perioperative myocardial infarction.

This meta-analysis evaluated the outcomes of patients with diffuse coronary disease undergoing coronary artery bypass grafting (CABG) combined with coronary endarterectomy (CE). The study included a total sample size of 7302 patients to compare the safety and efficacy of multivessel CE as an adjunct to CABG versus single-vessel CE as an adjunct to CABG. The primary objective was to determine the impact of the number of vessels undergoing endarterectomy on early mortality rates.

The primary outcome measured was 30-day or in-hospital mortality. The analysis revealed that multivessel CE was associated with a significantly higher risk of mortality compared to single-vessel CE, with a reported relative risk (RR) of 2.59 (95% CI, 1.78 to 3.77). This finding suggests a substantial increase in early mortality when multiple vessels are treated with endarterectomy in the context of diffuse disease.

Secondary outcomes included perioperative myocardial infarction, stroke, and the requirement for intra-aortic balloon pump (IABP) use. For perioperative myocardial infarction, multivessel CE showed a significantly higher risk with an RR of 2.09 (95% CI, 1.67 to 2.62). Stroke was also more frequent in the multivessel group, with an RR of 1.62 (95% CI, 1.01 to 2.61). In contrast, there was no reported difference in the requirement for intra-aortic balloon pump use between the two groups.

Regarding safety and tolerability, the study identified mortality as a serious adverse event and noted higher rates of perioperative myocardial infarction and stroke in the multivessel group. No specific data regarding treatment discontinuations or general tolerability scores were provided. The findings remained stable even after leave-one-out analysis, HKSJ adjustment, and the exclusion of studies published before 2000, suggesting the results are robust across different subsets of the included data.

These results provide critical context for the management of diffuse coronary disease. While the study does not provide a direct comparison to other specific coronary interventions, it highlights the specific risks associated with the extent of endarterectomy. The findings suggest that multivessel CE substantially increases early mortality and infarction relative to single-vessel CE. This supports a selective approach to CE, where the decision to perform endarterectomy is guided by the specific prognostic value of the target vessels rather than a broad application to all available vessels.

There are notable limitations to these findings. The evidence is largely based on retrospective studies and is largely unadjusted for potential confounders. Because the data are derived from retrospective reports, the association between multivessel CE and increased mortality should be interpreted with caution regarding causality.

Clinical implications for practice suggest that clinicians should weigh the potential benefits of multivessel endarterectomy against the significantly higher risks of mortality and myocardial infarction. The data suggest that a more targeted approach to coronary endarterectomy may be safer for patients with diffuse disease. Questions remain regarding the specific anatomical features of the vessels that most significantly contribute to these risks and how these risks change in different patient risk profiles.

How this fits prior evidence

How this fits prior evidence: This finding addresses the management of diffuse coronary disease. While prior evidence noted that focal and mixed coronary artery disease phenotypes show higher revascularization rates than diffuse patterns, this current meta-analysis highlights the specific risks of multivessel endarterectomy within those diffuse patterns. It provides a specific risk profile for the extent of endarterectomy in patients with diffuse disease.

When a person suffers from coronary artery disease, their heart muscles may not get enough blood. Doctors often perform a coronary artery bypass grafting, or CABG, to create new pathways for blood flow. In some cases, they also perform a procedure called coronary endarterectomy. This involves removing plaque from the artery walls. While this can be a helpful tool, choosing how many vessels to treat during one surgery is a critical decision for patient safety.

To understand the risks involved, researchers looked at data from 7,302 patients who underwent these procedures. They compared patients who had a single-vessel endarterectomy with those who had a multivessel endarterectomy performed alongside their bypass surgery. The goal was to see if treating multiple vessels at once changed the immediate risks for the patient.

The findings showed a significant difference in outcomes for those undergoing multivessel procedures. Patients who had multiple vessels treated saw a much higher risk of death within 30 days or during their hospital stay. Additionally, these patients faced a higher risk of suffering a heart attack during the surgery and a higher risk of suffering a stroke. One specific metric, the need for an intra-aortic balloon pump, did not show a difference between the two groups.

It is important to keep these findings in perspective. The data comes from a meta-analysis, which is a study that combines results from several other studies. However, many of those original studies were retrospective, meaning they looked back at past records rather than following patients in a controlled, forward-looking trial. Some of the data was also unadjusted, meaning it did not account for every possible outside factor that could influence a patient's health.

Because of these limitations, this study does not mean that multivessel procedures should be avoided entirely. Instead, it suggests that doctors should be very selective. The results support a careful approach where the decision to perform a multivessel endarterectomy is based on the specific health needs and the likely benefits for the patient's specific arteries.

For patients right now, this means that their surgical team will likely use these findings to guide their choices. Rather than a one-size-fits-all approach, doctors can use this data to weigh the risks of more complex procedures against the potential benefits. The focus remains on choosing the safest path to improve long-term heart health.

What this means for you:
Multivessel endarterectomy during heart surgery is linked to higher rates of stroke and heart attack.

Study Details

Study typeMeta analysis
Sample sizen = 7,302
EvidenceLevel 1
PublishedNov 2026
View Original Abstract ↓
OBJECTIVES: Coronary endarterectomy (CE) extends complete revascularization to patients with diffuse coronary disease unsuitable for conventional bypass but adds perioperative risk to coronary artery bypass grafting (CABG). Whether the number of vessels endarterectomized influences early outcomes has not been formally synthesized. We compared short-term outcomes of single-vessel and multivessel CE-CABG. METHODS: MEDLINE, Embase, and CENTRAL were searched for studies of CE-CABG reporting outcomes stratified by single-vessel vs multivessel CE within the same cohort. The primary outcome was 30-day or in-hospital mortality. Risk ratios (RR) were pooled using DerSimonian-Laird random-effects models. Sensitivity analyses included leave-one-out analysis, Hartung-Knapp-Sidik-Jonkman (HKSJ) adjustment, and univariate meta-regression on study-level covariates. Risk of bias was assessed with ROBINS-I. RESULTS: Nine studies (1988-2022; 7302 patients; 4731 single-vessel CE, 2571 multivessel CE) met inclusion criteria. Multivessel CE was associated with higher mortality (RR, 2.59; 95% CI, 1.78-3.77), higher perioperative myocardial infarction (RR, 2.09; 95% CI, 1.67-2.62), and higher stroke (RR, 1.62; 95% CI, 1.01-2.61). Intra-aortic balloon pump use did not differ. Findings were stable on leave-one-out, HKSJ adjustment, and exclusion of pre-2000 studies. No single covariate accounted for the multivessel effect on meta-regression. CONCLUSIONS: Multivessel CE substantially increases early mortality and infarction relative to single-vessel CE. The signal is consistent across analyses but the evidence is largely retrospective and unadjusted. These data support a selective approach to CE in which the prognostic value of each target vessel is weighed against the cumulative operative cost, rather than routine extension of endarterectomy to multiple territories.
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