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Off-pump CABG showed similar wound complications but fewer transfusions and shorter stays versus on-pump CABG in 394 patientsOff-Pump Surgery Does Not Reduce Leg Wound Risks In Heart Patients

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Key Takeaway
Consider that OPCAB reduces transfusions and hospital stays but does not lower wound complications compared to on-pump CABG.

This single-center retrospective cohort study included 394 patients who underwent isolated coronary artery bypass grafting with available pre- and postoperative coronary angiography. The analysis utilized propensity score matching to create 157 matched pairs comparing off-pump coronary artery bypass grafting (OPCAB) against conventional on-pump coronary artery bypass grafting (CABG). The primary outcome assessed leg wound complications, while secondary outcomes included early graft occlusion, saphenous vein graft stenosis, reintervention, perioperative outcomes, and major adverse cardiac and cerebrovascular events (MACCE). Follow-up extended up to 10 years.

Regarding wound healing, leg wound complications occurred in 1.3% of the OPCAB group versus 0.6% in the on-pump group, with a p-value of 1.00 indicating no significant difference. Early graft occlusion rates were 9.6% for OPCAB and 10.3% for on-pump CABG (p = 0.553). Saphenous vein graft occlusion occurred in 5.7% of OPCAB patients compared to 4.5% in the on-pump group (p = 0.798). Thirty-day mortality was 12.1% in both groups, and 12-month MACCE rates were also identical at 12.1%.

Resource utilization favored the off-pump approach. Red blood cell transfusions were fewer in the OPCAB group at 49.7% versus 64.3% in the on-pump group (p = 0.012). Operative time, intensive care unit stay, and hospital stay were all shorter in the OPCAB group, though specific duration values were not reported. No significant differences were found for long-term MACCE-free survival.

The study was limited to a single-center setting. Funding or conflicts of interest were not reported. While OPCAB improved perioperative resource utilization, it did not reduce GSV harvest-site complications compared with on-pump CABG. These findings are derived from an observational design and associations should be interpreted with caution regarding causality.

Imagine walking into the hospital for heart surgery. You want the best chance to heal quickly and avoid pain. Many people worry about the cuts made in their legs to take veins for the bypass. These wounds can sometimes get infected or fail to heal properly.

Doctors have long hoped that avoiding the heart-lung machine would protect these leg sites. The theory was that less blood flow disruption would mean less stress on the leg veins. But a new study from 2026 asks if this hope is still true today.

The Reality Of Modern Heart Surgery

Heart disease affects millions of people worldwide. Coronary artery bypass grafting is a common fix for blocked arteries. Surgeons take a healthy vein from the leg and connect it to the heart.

The main goal is to restore blood flow and reduce chest pain. However, the leg wound can be a source of trouble. Infections here can delay recovery and cause extra suffering for the patient.

For years, surgeons believed that doing the surgery without the heart-lung machine would help. This method is called off-pump coronary artery bypass grafting. The idea was that the body would handle the stress better without the machine.

A Twist In The Thinking

But here is the twist. A new look at data from 2005 to 2017 tells a different story. Researchers compared patients who had the heart-lung machine with those who did not. They found no difference in leg wound problems between the two groups.

The study looked at 394 patients total. They used a special matching method to ensure the groups were very similar. This means the results are fair and not skewed by other health issues.

How The Body Handles The Stress

Think of the leg vein like a garden hose. When you connect it to the heart, you are moving it from one place to another. The body reacts to this change.

When the heart stops beating during surgery, blood flow to the legs changes. This can cause swelling or poor healing. Surgeons thought avoiding the heart-lung machine would stop this reaction.

However, the body reacts to the surgery itself. The incision and the manipulation of the vein cause the main stress. The heart-lung machine is just one part of the process.

What The Study Actually Tested

This single-center study included 394 patients who had isolated heart bypass surgery. They had angiograms before and after the operation to check the grafts. The researchers matched 157 patients from each group carefully.

They looked at leg wound complications as the main goal. They also checked for early graft blockage and other heart events. The study tracked patients for up to ten years to see long-term results.

The Surprising Findings

The results were clear and surprising. Leg wound complications were rare in both groups. Only 1.3 percent of patients had issues in the on-pump group. Just 0.6 percent had issues in the off-pump group.

This difference was not statistically significant. In plain English, the numbers were too close to call a winner. Both methods had similar risks for the leg incision.

Early graft blockage was also similar. About 9.6 percent of grafts blocked early in the on-pump group. The off-pump group saw 10.3 percent blockage. These numbers are very close.

But There Is A Catch

This does not mean the off-pump method is useless. It just means it does not fix the leg wound problem specifically.

The study did find real benefits for the off-pump group. Patients had shorter surgery times. They needed fewer red blood cell transfusions. Their time in the intensive care unit was shorter too. Hospital stays were also reduced.

These are important improvements for recovery. Less time in the hospital means less exposure to germs. Fewer transfusions mean less risk of reactions.

What Experts Say About This

Experts note that the off-pump technique is still valuable. It reduces resource use and speeds up recovery. However, it does not solve the leg wound issue.

The field is moving toward better wound care techniques. Surgeons are looking at new ways to protect the leg incision. This might include better dressings or different surgical approaches.

If you are considering heart surgery, talk to your doctor about the options. Ask about the risks of leg wounds specifically. Understand that avoiding the heart-lung machine does not guarantee a better leg outcome.

The choice between methods depends on your specific heart condition. Your surgeon will weigh the benefits of shorter stays against the wound risks. Both methods have their place in modern medicine.

This study was done at one hospital. It included patients from 2005 to 2017. The techniques used may have changed since then. Newer tools might change the results.

The sample size was large, but it is still just one center. More hospitals need to study this question. We need data from many places to be sure.

Future research will focus on wound care improvements. Scientists are testing new dressings and surgical methods. The goal is to protect the leg incision without stopping the heart-lung machine.

Patients should stay informed about new treatments. Medical science moves fast. What is true today might change tomorrow. Always ask your doctor about the latest options.

The off-pump method remains a valid choice. It offers clear benefits for recovery time and resource use. It just does not fix the leg wound risk. Both methods are tools in the surgeon's toolbox.

Study Details

Study typeCohort
EvidenceLevel 3
PublishedApr 2026
View Original Abstract ↓
BackgroundThe impact of off-pump coronary artery bypass grafting (OPCAB) on great saphenous vein (GSV) harvest-site wound complications and graft integrity remains uncertain in the contemporary era. We compared harvest-site morbidity, early angiographic outcomes, and long-term clinical events between OPCAB and conventional on-pump coronary artery bypass grafting (CABG).MethodsThis single-center retrospective study included 394 patients who underwent isolated CABG with available pre- and postoperative coronary angiography between 2005 and 2017. Propensity score matching according to pump usage yielded 157 matched pairs [on-pump CABG, n = 157; OPCAB, n = 157]. The primary endpoint was GSV harvest-site wound complications. Secondary endpoints included early graft occlusion or saphenous vein graft (SVG) stenosis, reintervention, perioperative outcomes, and major adverse cardiac and cerebrovascular events (MACCE).ResultsAfter matching, baseline characteristics were comparable, although the on-pump group had more distal anastomoses. Leg wound complications were rare and similar between groups (1.3% vs. 0.6%, p = 1.00). Early graft occlusion (9.6% vs. 10.3%, p = 0.553) and SVG occlusion (5.7% vs. 4.5%, p = 0.798) did not differ significantly. SVG stenosis severity and reintervention rates were comparable. OPCAB was associated with shorter operative time, fewer red blood cell transfusions (49.7% vs. 64.3%, p = 0.012), shorter intensive care unit stay, and reduced hospital stay. Thirty-day mortality and 12-month MACCE rates (12.1% in both groups) were similar. Long-term MACCE-free survival up to 10 years showed no significant difference.ConclusionOPCAB did not reduce GSV harvest-site complications compared with on-pump CABG. Early graft integrity and long-term clinical outcomes were comparable, although OPCAB improved perioperative resource utilization.
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