Narrative review suggests exercise rehabilitation may retard Cardiovascular-Kidney-Metabolic Syndrome progression

This narrative review examines the mechanisms and research progress of exercise rehabilitation for Cardiovascular-Kidney-Metabolic Syndrome. The review describes exercise rehabilitation as an effective non-pharmacological intervention that may retard CKM progression through multi-target mechanisms, though specific effect sizes, absolute numbers, and statistical measures are not reported. No safety, tolerability, or adverse event data are presented in the review.

The review's primary limitation is its narrative nature—it summarizes existing literature without conducting new data synthesis, meta-analysis, or reporting specific clinical outcomes. Key methodological details including study population, sample size, setting, follow-up duration, and comparator groups are not reported. The review does not specify which studies were included or the quality of the evidence reviewed.

From a practice perspective, this review provides a theoretical basis for comprehensive CKM management but offers no new clinical data to guide specific exercise prescriptions. The authors describe an association between exercise and potential CKM benefits, but the evidence remains preliminary and descriptive. Clinicians should recognize this as a summary of research progress rather than evidence supporting specific clinical protocols.