Systematic review and meta-analysis reports 36.6% cognitive impairment prevalence in coronary heart disease patients
Photo by Ecliptic Graphic / Unsplash
Key Takeaway
Consider age, stroke history, and smoking as risk factors for cognitive impairment in CHD patients.
This systematic review and meta-analysis examines the prevalence of cognitive impairment and associated risk factors among patients with coronary heart disease. The analysis included data from 9,207 patients to determine the overall burden of cognitive dysfunction in this population.
The primary outcome showed a pooled prevalence of cognitive impairment at 36.6% (95% CI 27.6%–45.7%). Several specific risk factors were evaluated to understand their contribution to cognitive decline in these patients.
Age was identified as a risk factor with an odds ratio of 1.10 (95% CI 1.04–1.17, P = 0.001). A history of stroke was associated with an odds ratio of 1.99 (95% CI 1.09–3.62, P = 0.02). Smoking showed the strongest association with an odds ratio of 3.05 (95% CI 2.00–4.66, P = value not reported).
The review did not report adverse events, discontinuations, or tolerability data. Because the study synthesizes observational data, causal language is avoided. The findings provide a reference for the implementation of targeted interventions but require cautious interpretation regarding clinical management.
More on Cognitive Impairment
Systematic review and meta-analysis of Zingiberaceae-derived interventions for memory-related outcomes in adults
Turmeric and Ginger May Boost Memory, New Research Shows
This systematic review and meta-analysis evaluated Zingiberaceae-derived interventions, including curcumin, turmeric, ginger, and related pr…
Forget the spice rack debate: turmeric and ginger may actually sharpen your memory, but only for certain types of thinking, according to a n…
Ashwagandha supplementation shows cognitive and physical benefits in adults
Your Brain and Muscles Could Get Stronger with This Common Herb
A meta-analysis of 20 studies found ashwagandha significantly improved memory, attention, and muscle strength in adults, with no effect on b…
• Ashwagandha significantly boosts memory and muscle strength in adults • Helps adults seeking natural cognitive and physical support daily …
Meta-analysis finds combined exercise and tDCS improves cognition in older adults
Combined exercise and brain stimulation may help older adults with memory
This meta-analysis of randomized controlled trials synthesized evidence on combined exercise and transcranial direct current stimulation for…
A review of trials suggests pairing exercise with brain stimulation can boost memory and thinking in older adults with cognitive issues.
Narrative review links soil contaminants and micronutrient depletion to hypertension, atherosclerosis, and neurodegenerative processes
The Hidden Link Between Dirty Soil and Your Heart and Brain
This narrative review synthesizes a plausible pathophysiologic framework linking soil contaminants and depleted essential micronutrients to …
The soil your food grows in may be quietly damaging your heart and brain, and experts say we have been overlooking this danger for too long.
View Original Abstract ↓
BackgroundThe prevalence and risk factors of cognitive impairment in patients with coronary atherosclerotic heart disease (CHD) vary substantially depending on the measurement approaches and time points adopted. Through a meta-analysis, we aim to clarify the prevalence and risk factors of cognitive impairment in CHD patients, thereby providing a reference for the implementation of targeted interventions.MethodsComputerized searches were conducted across 9 databases, including the China National Knowledge Infrastructure (CNKI), VIP Database, Wanfang Database, China Biomedical Literature Database (CBM), PubMed, Cochrane Library, Embase, Medline, and Web of Science, to retrieve literature on risk factors for cognitive impairment in patients with coronary heart disease (CHD). Searches were run from database inception to July 2025. After literature screening, data extraction and quality assessment, a meta-analysis was performed using Stata 16.0 and RevMan 5.4 software.ResultsA total of 22 studies were included, involving 9,207 patients. The prevalence of cognitive impairment in CHD patients was 36.6% [95% CI (27.6%–45.7%)]. Meta-analysis and systematic review revealed that age [OR: 1.10 (1.04–1.17), P = 0.001], history of stroke [OR: 1.99 (1.09–3.62), P = 0.02], smoking [OR: 3.05 (2.00–4.66), P
Oral semaglutide reduces composite heart failure outcomes in patients with type 2 diabetes and heart failure history
A Common Diabetes Pill May Also Protect Your Heart From Failure
Related in Cardiology
Systematic review and meta-analysis finds no mortality benefit for alternative loop diuretics in chronic heart failure
Alternative heart failure diuretics show no mortality benefit but higher risk
This meta-analysis of 23 RCTs with 4902 patients with chronic heart failure found that alternative loop diuretics did not reduce all-cause m…
A review of 23 trials found alternative diuretics did not lower death risk in heart failure patients, but some raised safety concerns.
Review discusses digital twin architecture for predicting aortic disease progression versus static thresholds
Digital Twins Predict Aortic Aneurysm Growth Before It Becomes Dangerous
This review examines the potential of patient-specific digital twin architecture for managing patients with aortic disease. The authors cont…
A new digital twin model predicts how your aortic aneurysm will grow, helping doctors time treatment earlier and more precisely.
RAS inhibitor use after TAVI linked to lower mortality in severe aortic stenosis
Common Heart Pill May Boost Survival After Valve Replacement
This systematic review and meta-analysis of observational data from 36,015 patients with severe aortic stenosis undergoing TAVI found that u…
A common class of blood pressure pills appears to help people live longer after minimally invasive heart valve replacement, but doctors stil…
Health and Wellness coaching for blood pressure control in minor stroke or TIA
Your Daily Habits Could Shield You From Another Stroke
This is a Phase III randomized controlled trial protocol for adults with minor stroke or transient ischaemic attack in New Zealand. The stud…
• Lifestyle coaching cuts blood pressure better than standard care.
From Other Specialties
Psychological interventions significantly reduce anxiety and depression in cancer pain patients compared to conventional care
Cancer Pain Patients Find Unexpected Relief Through Talk Therapy
This meta-analysis evaluated psychological interventions for anxiety and depression in cancer pain patients. The analysis included 879 parti…
• Talk therapy cuts anxiety and depression scores by nearly 9 points • Helps patients suffering pain during chemotherapy or radiation • Not …
Meta-analysis of GWAS in Native Hawaiians and Polynesians identifies 25 trait loci for diabetes and obesity traits
Genome scans in Native Hawaiians and Polynesians reveal 25 genetic links to diabetes traits
This meta-analysis review synthesized genome-wide association studies in Native Hawaiians and Polynesian-ancestry populations. It identified…
A large genetic analysis found 25 confirmed links between DNA variants and traits like blood sugar in Native Hawaiian and Polynesian populat…
Acupuncture combined with Chinese medicine reduces cancer pain intensity compared to usual care in a meta-analysis of 884 patients
Cancer Patients Feel Less Pain With Acupuncture and Herbal Therapy Today
This systematic review and meta-analysis evaluated acupuncture combined with Chinese medicine versus acupuncture alone, analgesic therapy, o…
• Acupuncture plus Chinese herbs cuts cancer pain better than standard treatments • Helps people with moderate to severe pain from cancer ca…
Intraosseous route for out-of-hospital cardiac arrest linked to lower outcomes than intravenous access
Using a bone needle instead of a vein line lowers survival chances for cardiac arrest patients
This systematic review and meta-analysis of 245,132 out-of-hospital cardiac arrest patients found that intraosseous access was associated wi…
A huge study of over 245,000 people found that putting medicine into a bone vein works worse than using a standard arm vein. Doctors should …