Review analyzes PANoptosis mechanisms and potential treatments for ischemia-reperfusion injury

This systematic review examines the concept, molecular mechanisms, detection methods, and regulatory networks of PANoptosis in various ischemia-reperfusion injuries. The analysis explores potential treatment strategies targeting PANoptosis, including small molecule inhibitors, natural products, gene intervention, and stem cell therapy. The review characterizes PANoptosis as a newly described inflammatory cell death form that incorporates features of pyroptosis, apoptosis, and necroptosis, with its own regulatory mechanisms playing an important role in IRI occurrence.

No primary clinical data, effect sizes, or safety outcomes from trials are reported. The review does not specify study populations, sample sizes, settings, interventions, comparators, or follow-up durations. Adverse events, serious adverse events, discontinuations, and tolerability data are not reported.

Key limitations include the absence of primary clinical evidence and unspecified methodology details. The treatment strategies discussed remain theoretical analyses without reported clinical efficacy or safety data. Practice relevance is not established, as this review synthesizes conceptual and mechanistic information rather than clinical trial results. Funding sources and conflicts of interest are not reported.