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Coastal regions show higher thyroid cancer prevalence while inland areas have more goiter and hypothyroidismGeographic Location Linked to Different Types of Thyroid Disorders

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Key Takeaway
Note that geographical location and iodine status are associated with differing patterns of thyroid cancer and goiter.

This systematic review synthesizes evidence regarding the distribution of thyroid disorders across different geographical locations, specifically comparing coastal and inland populations. The scope includes the impact of iodine status, seafood consumption, and environmental pollutants such as bisphenol A and polychlorinated biphenyls on thyroid cancer, nodules, goiter, and hypothyroidism.

The synthesis indicates that coastal populations exhibit a higher prevalence of thyroid cancer and thyroid nodules. Conversely, goiter and hypothyroidism are more prevalent in inland and mountainous areas. In both geographical settings, female gender and older age were significantly associated with a greater burden of disease.

A primary limitation noted by the authors is the lack of longitudinal studies to identify causal pathways from socioeconomic factors and environmental determinants. The review notes that while associations exist between geography, iodine levels, and pollutants, these are not established as direct causal links. Clinical relevance lies in recognizing geographical location as a determinant of thyroid disorder distribution due to varying iodine intake and pollutant exposure.

How this fits prior evidence

This systematic review addresses gaps regarding the environmental and geographic determinants of thyroid disorders. While previous coverage has focused on precision immunotherapy for thyroid cancer, immune-inflammation indices for risk stratification, and genomic profiling for treatment selection, this evidence adds a layer of epidemiological context regarding how geography and iodine status influence disease prevalence.

A systematic review looked at how where people live affects their risk for thyroid issues. The study compared people living in coastal areas to those living in inland or mountainous regions. It also looked at factors like iodine levels, seafood consumption, and exposure to environmental pollutants.

The findings show a link between location and specific conditions. People in coastal areas showed a higher prevalence of thyroid cancer and thyroid nodules. In contrast, people in inland and mountainous areas had more cases of goiters and hypothyroidism. These differences are likely linked to local iodine levels and different types of environmental exposure.

While the study shows these links, it is important to note that researchers cannot say for certain what causes these conditions based on this data alone. More long-term studies are needed to understand exactly how pollutants or iodine levels impact health. For now, the results show that geography plays a role in where certain thyroid diseases are most common.

What this means for you:
Coastal areas show higher rates of thyroid cancer, while inland areas show more goiters and hypothyroidism.

Common questions

Why do different locations have different thyroid issues?

The study suggests that geography is a key factor because it affects how much iodine people get from their diet and the types of pollutants they encounter. Coastal areas showed more thyroid cancer and nodules, while inland and mountainous areas showed higher rates of goiters and hypothyroidism.

Are environmental pollutants causing these thyroid conditions?

The review found a link between certain pollutants like bisphenol A and polychlorinated biphenyls and thyroid issues. However, the study does not prove that these pollutants directly cause the diseases; more long-term research is needed to confirm exactly how they affect health.

Who is most at risk for these thyroid conditions?

The data shows that being female and being older are both significantly associated with a higher burden of thyroid disease in both coastal and inland regions. These factors were consistent across the different geographic locations studied.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedJul 2026
View Original Abstract ↓
BackgroundEndocrine conditions such as thyroid disorders can significantly impact maternal and child health. Key determinants such as environmental setting and presence of iodine can influence the incidence of thyroid disorders. Individuals living in coastal regions are exposed to iodine rich foods in comparison to those residing in inland areas, which is a possible differentiating factor in the occurrence of thyroid based diseases in these individuals. Despite this possible relationship, very few studies have investigated the burden of thyroid diseases amongst coastal and inland populations.ObjectiveThe study aims to systematically explore the prevalence of thyroid disorders in coastal and inland regions to understand the impact of differences in diet, environmental determinants, demographic variation and access to healthcare services on thyroid disease occurrence.MethodsDatabases such as PubMed, Google Scholar and Scopus were used to identify articles in accordance with the PRISMA 2020 guidelines. Twenty three articles were selected based on them being in the English language, full length studies published between January 2017 and September 2023 and had reported on prevalence of thyroid diseases in inland and/or coastal areas.ResultsThe review identified that a higher prevalence of thyroid cancer and thyroid nodules were seen amongst coastal populations, while goiter and hypothyroidism were seen in inland and mountainous areas. These differences were influenced by the iodine status of the region, consumption of seafood, presence of environmental pollutants like bisphenol A and polychlorinated biphenyls, iodization of salt, socioeconomic conditions and healthcare access. Female gender and older age was found to be significantly associated with greater burden of disease in both areas of study.ConclusionThe geographical location or setting is a vital determinant of the distribution of thyroid disorders, mainly through the influence of iodine intake and exposure to environmental pollutants. Regular monitoring of environmental pollutants, early detection of cases, universal iodization of salt and proactive supplementation of iodine may lead to decreased prevalence of thyroid disorders and its consequences. Longitudinal studies in this field can help identify the causal pathways emerging from socioeconomic factors and environmental determinants to thyroid disorders.
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