Evidence-Based Medical News

Mode

All Infectious Disease Oncology Neurology Cardiology Psychiatry Diabetes & Endocrinology Pediatrics Allergy & Immunology Rheumatology Gastroenterology Primary Care & Family Medicine Nutrition & Obesity Medicine OB/GYN & Women's Health Orthopedics & Sports Medicine Genetics & Precision Medicine Radiology & Imaging Pulmonology & Critical Care Anesthesiology & Pain Medicine Physical Medicine & Rehab Nephrology Hematology Dermatology Urology Emergency Medicine Ophthalmology Geriatrics & Aging ENT (Otolaryngology) Palliative Care

Research

Clinical Trials Drug Pipeline Weekly Digests

Reference

Conditions Medications

Community

Text Size

Log in / Sign up

Hypothyroidism

7 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Hypothyroidism

13 trials tracked for Hypothyroidism: 3 in phase 3 or 4 and 1 with published results. The most-cited published study has 86 citations.

13Trials tracked

3Phase 3 & 4

0Recruiting

1With published results

Phase distribution

Phase 4 3 Phase 2 4 Other / NA 6

Phase 4 Neurocognitive and Metabolic Effects of Mild Hypothyroidism Completed · 86 cited
Phase 4 Hypothyroidism Treated With Calcitonin Completed
Phase 4 Study to Verify Clinical Utility of Point-of-Care (POC) Thyroid Stimulating Hormone (TSH) Test Kits as Compared to Third Generation TSH Test Kit Completed
Phase 2 Study of Dose Adjustment From Levothyroxine to a New Levothyroxine Sodium Test Formulation Completed
Phase 2 Energy Metabolism in Thyroidectomized Patients Completed
Phase 2 A Study of Armour® Thyroid Compared to Synthetic T4 (Levothyroxine) in Previously Hypothyroid Participants Completed

Show 7 more trials

Phase 2 Study of XP-8121 For the Treatment of Adult Subjects With Hypothyroidism Completed
N/A Generic vs. Name-Brand Levothyroxine Completed
N/A Swallowing Function Before and After Surgery for Thyroid Goiter Completed
N/A Observational Study on Hypothyroidism in Young Children Following Iodine Contrast Exposure Completed
N/A Bone Structure and Strength Evaluated by Extreme-CT Scan Before and After Treatment of Hyper- and Hypothyroidism Completed
N/A Iodinated Contrast Agents and Risk of Hypothyroidism in Young Children in the United States Completed
N/A Thyroid Hormone Dose Adjustment in Pregnancy Completed

Showing the 13 most-cited and recently-updated of 13 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

Questions about Hypothyroidism

Is levothyroxine approved for TSH suppression in hypothyroidism patients?

Levothyroxine is FDA-approved for TSH suppression only as an adjunct to surgery and radioiodine therapy for well-differentiated thyroid cancer, not for benign thyroid nodules or general hypothyroidism.

Full answer →

What TSH cutoff values are used for preterm infants with hypothyroidism?

TSH cutoff values for preterm infants vary by gestational age, birth weight, and postnatal age; a 2024 study suggests a 97.5th percentile cutoff around 7.38 μIU/mL in the third postnatal week, while older studies use cutoffs like 6 mU/L.

Full answer →

Does having hypothyroidism increase the risk of chronic kidney disease?

Yes, hypothyroidism is associated with a higher prevalence of chronic kidney disease, but the evidence on causing new CKD is less clear.

Full answer →

Can levothyroxine tablets treat primary and secondary hypothyroidism?

Yes, levothyroxine tablets are FDA-approved to treat both primary and secondary hypothyroidism as replacement therapy.

Full answer →