Mode
Home
Research
Clinical Trials Drug Pipeline Weekly Digests
Reference
Conditions Medications
Community
Questions
Text Size
Log in / Sign up
Home › Conditions › Hypothyroidism

Hypothyroidism

8 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Hypothyroidism

13 trials tracked for Hypothyroidism: 3 in phase 3 or 4 and 1 with published results. The most-cited published study has 87 citations.

13Trials tracked
3Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 3 Phase 2 4 Other / NA 6
  1. Phase 4 Neurocognitive and Metabolic Effects of Mild Hypothyroidism Completed · 87 cited
  2. Phase 4 Hypothyroidism Treated With Calcitonin Completed
  3. Phase 4 Study to Verify Clinical Utility of Point-of-Care (POC) Thyroid Stimulating Hormone (TSH) Test Kits as Compared to Third Generation TSH Test Kit Completed
  4. Phase 2 Study of Dose Adjustment From Levothyroxine to a New Levothyroxine Sodium Test Formulation Completed
  5. Phase 2 Energy Metabolism in Thyroidectomized Patients Completed
  6. Phase 2 A Study of Armour® Thyroid Compared to Synthetic T4 (Levothyroxine) in Previously Hypothyroid Participants Completed
Show 7 more trials
  1. Phase 2 Study of XP-8121 For the Treatment of Adult Subjects With Hypothyroidism Completed
  2. N/A Generic vs. Name-Brand Levothyroxine Completed
  3. N/A Swallowing Function Before and After Surgery for Thyroid Goiter Completed
  4. N/A Observational Study on Hypothyroidism in Young Children Following Iodine Contrast Exposure Completed
  5. N/A Bone Structure and Strength Evaluated by Extreme-CT Scan Before and After Treatment of Hyper- and Hypothyroidism Completed
  6. N/A Iodinated Contrast Agents and Risk of Hypothyroidism in Young Children in the United States Completed
  7. N/A Thyroid Hormone Dose Adjustment in Pregnancy Completed

Showing the 13 most-cited and recently-updated of 13 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Hypothyroidism: what the trials found

L-thyroxine (L-T4) is established as a standard intervention for the management of hypothyroidism 1.

Diagnostic monitoring and assessment in patients with hypothyroidism can be performed using Quantitative POC TSH Kits 3.

Research indicates that iodinated contrast agents are utilized in clinical contexts involving patients with an indication of hypothyroidism; however, baseline characteristics regarding the type of first examination showed significant differences between cases with and without a hypothyroidism indication (p=0.022) 10.

Iodinated contrast agents were also evaluated in large-scale cohorts for use in patients with thyroid conditions 9.

Recent results — preliminary, needs further review

  • Levothyroxine sodium is being investigated as an intervention 4.
  • Armour® Thyroid showed a sustained TSH response in 60.76% and 75.92% of participants, with titration TSH responses observed in 80.62% and 91.13% of patients respectively 6.

For the clinician treating this condition

  • L-thyroxine remains a primary established pharmacological intervention for hypothyroidism 1.
  • Point-of-care (POC) TSH kits are available for monitoring thyroid function in these patients 3.
  • Clinical data suggests that while iodinated contrast agents are used in this patient population, specific baseline characteristics regarding initial examination types may vary significantly between those with and without a confirmed hypothyroidism diagnosis 10.

AI synthesis of 6 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Coastal regions show higher thyroid cancer prevalence while inland areas have more goiter and hypothyroidism
Diabetes & Endocrinology Meta-analysis
Coastal regions show higher thyroid cancer prevalence while inland areas have more goiter and hypothyroidism Geographic Location Linked to Different Types of Thyroid Disorders
This systematic review examines the impact of geography, iodine status, and environmental pollutants on thyroid disorders. Findings indicate…
Research shows that coastal and inland regions have different rates of thyroid conditions like cancer, goiters, and hypothyroidism.
Frontiers Jul 21, 2026
Scoping review of fetal lymphangioma management in a case report series
Pediatrics Sys. Review
Scoping review of fetal lymphangioma management in a case report series Giant fetal cysts need careful care not just surgery for survival
This scoping review synthesizes evidence from one case report and 20 additional case reports regarding fetal abdominal and abdominopelvic ly…
A rare giant fluid cyst in a fetus shows that some cases need long-term support instead of immediate surgery for the best outcome
Frontiers May 7, 2026
FDA Approves Levothyroxine Sodium Tablets for Hypothyroidism and TSH Suppression
Diabetes & Endocrinology FDA Approval
FDA Approves Levothyroxine Sodium Tablets for Hypothyroidism and TSH Suppression FDA approves new thyroid hormone drug for hypothyroidism and thyroid cancer.
The FDA approved levothyroxine sodium tablets for replacement therapy in primary, secondary, and tertiary hypothyroidism, and as an adjunct …
The FDA has approved levothyroxine sodium tablets to treat hypothyroidism and as part of therapy for certain thyroid cancers. This synthetic…
FDA May 6, 2026
Nurse-led care coordination fails to improve medication adherence in high-need patients
Cardiology RCT
Nurse-led care coordination fails to improve medication adherence in high-need patients Nurse-led care coordination did not improve medication adherence for most common chronic conditions
This pragmatic randomized controlled trial tested nurse-led care coordination versus usual care in high-need, high-cost commercially insured…
A large trial found that nurse-led care coordination did not improve how often people took their diabetes, heart, or thyroid medications com…
May 1, 2026
Meta-analysis shows associations between hypothyroidism and increased chronic kidney disease prevalence
Diabetes & Endocrinology Meta-analysis
Meta-analysis shows associations between hypothyroidism and increased chronic kidney disease prevalence Hypothyroidism Linked To Kidney Issues But Treatment Does Not Fix Them
This meta-analysis of 46 studies examines the relationship between hypothyroidism, including subclinical cases, and kidney outcomes.
Untreated low thyroid levels are strongly tied to worse kidney function in adults, but taking thyroid medicine does not seem to improve kidn…
Frontiers May 1, 2026
Meta-analysis links higher FT3 and TgAb to permanent hypothyroidism after subacute thyroiditis
Diabetes & Endocrinology Meta-analysis
Meta-analysis links higher FT3 and TgAb to permanent hypothyroidism after subacute thyroiditis After Thyroid Inflammation, Some Patients Face Lifelong Hormone Issues—New Clues Explain Why
This systematic review and meta-analysis of 1294 patients with subacute thyroiditis found that higher free triiodothyronine (FT3) levels and…
This research helps doctors predict which patients will need lifelong thyroid medication after inflammation, allowing for earlier monitoring…
Frontiers Apr 22, 2026
Retrospective study derives gestational age and postnatal age specific TSH cutoffs for preterm infants
Pediatrics Cohort
Retrospective study derives gestational age and postnatal age specific TSH cutoffs for preterm infants One Size Does Not Fit All For Thyroid Checks In Premature Babies
This retrospective analysis of preterm infants undergoing neonatal blood screening between October 2017 and December 2022 examined thyroid-s…
Using the wrong numbers for thyroid checks in premature babies could miss a serious problem or flag a false alarm.
Frontiers Apr 16, 2026
RAI therapy shifts hyperthyroidism to hypothyroidism in HRAS-mutated HGDTC with hyperfunctioning metastases
Diabetes & Endocrinology Sys. Review
RAI therapy shifts hyperthyroidism to hypothyroidism in HRAS-mutated HGDTC with hyperfunctioning metastases Radioactive iodine therapy helped one patient with rare thyroid cancer metastases
A case report and literature review describes a 68-year-old woman with HRAS-mutated high-grade differentiated thyroid carcinoma (HGDTC) and…
Radioactive iodine therapy successfully treated a rare case of thyroid cancer that had spread to the lungs and bones while overproducing hor…
Frontiers Apr 2, 2026

Questions about Hypothyroidism

Is levothyroxine approved for TSH suppression in hypothyroidism patients?

Levothyroxine is FDA-approved for TSH suppression only as an adjunct to surgery and radioiodine therapy for well-differentiated thyroid cancer, not for benign thyroid nodules or general hypothyroidism.

Full answer →
What TSH cutoff values are used for preterm infants with hypothyroidism?

TSH cutoff values for preterm infants vary by gestational age, birth weight, and postnatal age; a 2024 study suggests a 97.5th percentile cutoff around 7.38 μIU/mL in the third postnatal week, while older studies use cutoffs like 6 mU/L.

Full answer →
Does having hypothyroidism increase the risk of chronic kidney disease?

Yes, hypothyroidism is associated with a higher prevalence of chronic kidney disease, but the evidence on causing new CKD is less clear.

Full answer →
Can levothyroxine tablets treat primary and secondary hypothyroidism?

Yes, levothyroxine tablets are FDA-approved to treat both primary and secondary hypothyroidism as replacement therapy.

Full answer →