Clinical and laboratory abnormalities linked to higher mortality in malaria patients with acute kidney injury

This systematic review and meta-analysis aims to evaluate the predictors of mortality in malaria patients with AKI. Studies were searched in PubMed, Scopus, Ebsco, and ScienceDirect. We included observational studies that showed the association between clinical or laboratory abnormalities and mortality, reported in odds ratio. The quality of each study was assessed using the Newcastle-Ottawa Scale. Meta-analysis was performed using R. Sixteen studies with 1,104 patients were analyzed. Factors significantly associated with mortality were respiratory distress syndrome (OR: 18.50,  < 0.001), neurological involvement (OR: 12.83,  < 0.001), disseminated intravascular coagulation (OR: 12.00,  < 0.001), hypotension (OR: 18.23,  < 0.001), oliguria (OR: 3.41,  = 0.002), ventilator requirement (OR: 30.35,  < 0.001), leukocytosis (OR: 4.87,  = 0.003), hyponatremia (OR: 3.67,  = 0.048), acidosis (OR: 4.88,  < 0.001), hyperkalemia (OR: 3.99,  < 0.001), and jaundice (OR: 5.03,  = 0.001). ARDS, neurological involvement, DIC, hypotension, oliguria, ventilator requirement, leukocytosis, hyponatremia, acidosis, hyperkalemia, and jaundice were associated with mortality in malaria patients with AKI. The findings underscored the importance of heightened awareness and vigilance in managing patients with these conditions.