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Home › Conditions › Malaria

Malaria

Subtypes of Malaria

Plasmodium falciparum Malaria 2

26 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Malaria

123 trials tracked for Malaria: 27 in phase 3 or 4 and 18 with published results. The most-cited published study has 241 citations.

123Trials tracked
27Phase 3 & 4
0Recruiting
18With published results
Phase distribution
Phase 4 5 Phase 3 22 Phase 2 36 Phase 1 41 Other / NA 19
  1. Phase 3 Reducing the Burden of Malaria in HIV-uninfected Pregnant Women and Infants Completed · 241 cited
  2. Phase 3 Novel Use Of Hydroxyurea in an African Region With Malaria Completed · 153 cited
  3. Phase 3 Pyronaridine Artesunate (3:1) Versus Coartem® in P Falciparum Malaria Patients Completed · 144 cited
  4. Phase 3 Repeat Ivermectin Mass Drug Administrations for Control of Malaria: a Pilot Safety and Efficacy Study Completed · 143 cited
  5. Phase 3 Prevention of Malaria in HIV-uninfected Pregnant Women and Infants Completed · 130 cited
  6. Phase 3 HIV Protease Inhibitors for the Prevention of Malaria in Ugandan Children Completed · 112 cited
Show 44 more trials
  1. Phase 3 Pyronaridine Artesunate (3:1) in Children and Adults With Acute Plasmodium Vivax Malaria Completed · 108 cited
  2. Phase 3 Pyronaridine Artesunate 3:1 Granule Formulation vs. Coartem© Crushed Tablets in P. Falciparum Malaria Pediatric Patients Completed · 90 cited
  3. Phase 3 An Extension to Study MALARIA-055 PRI (NCT00866619) to Evaluate the Long-term Efficacy, Safety and Immunogenicity of GSK Biologicals' Candidate Malaria Vaccine in Infants and Children in Africa Completed · 70 cited
  4. Phase 3 Intermittent Preventive Treatment of Malaria in Schoolchildren Completed · 63 cited
  5. Phase 3 Protease Inhibitors to Reduce Malaria Morbidity in HIV-Infected Pregnant Women Completed · 51 cited
  6. Phase 4 A Study to Assess Safety of Current Standard Malaria Treatment and an Assessment of G6PD Status in South-east Bangladesh Completed · 48 cited
  7. Phase 3 Reducing the Burden of Malaria in HIV-Infected Pregnant Women and Their HIV-Exposed Children (PROMOTE-BC2) Completed · 47 cited
  8. Phase 3 Safety and Immunogenicity of GSK Biologicals' Investigational Malaria Vaccine in HIV Infected Infants and Children Completed · 34 cited
  9. Phase 3 Repeat Ivermectin Mass Drug Administrations for MALaria Control II Completed · 24 cited
  10. Phase 3 Optimal Chemopreventive Regimens to Prevent Malaria and Improve Birth Outcomes in Uganda Completed · 12 cited
  11. Phase 3 Efficacy of GSK Biologicals' Candidate Malaria Vaccine 257049 Against Malaria Disease in Infants and Children in Africa Completed · 12 cited
  12. Phase 4 Gut and Azithromycin Mechanisms in Infants and Children II Completed · 5 cited
  13. Phase 4 Epidemiology Study of Malaria Transmission Intensity in Sub-Saharan Africa Completed
  14. Phase 4 Evaluation of Potential Effect of Artemether - Lumefantrine and Malaria Drugs on Auditory Function Completed
  15. Phase 4 A Community Setting Study of Malaria After Systematic Treatment of Symptomatic Carriers of P. Falciparum With COA566 (Coartem®) Completed
  16. Phase 3 Consistency of Immunogenicity and Non Inferiority of GSK Biologicals' Candidate Malaria Vaccine Lots in Children Completed
  17. Phase 3 Immunogenicity and Safety Study of GSK Biologicals' Candidate Malaria Vaccine Given at 6, 7.5 and 9 Months of Age in Co-administration With Measles, Rubella and Yellow Fever (YF) Vaccines Followed by a Booster of the Malaria Vaccine. Completed
  18. Phase 3 Artemisinin-Based Combination Therapy: Clinical Trials in Cameroon Completed
  19. Phase 3 Chemopreventive Therapy for Malaria in Ugandan Children Completed
  20. Phase 3 Study to Evaluate Immunogenicity of the Hepatitis B Antigen of the GSK Biologicals' Candidate Malaria Vaccine (257049) Completed
  21. Phase 3 Chloroquine for Malaria in Pregnancy Completed
  22. Phase 2 Examine Safety and Immune Responses of GSK 257049 Vaccine When Administered to Infants Living in a Malaria-endemic Region Completed
  23. Phase 2 Safety and Immunogenicity Study of GSK Biologicals' Malaria Vaccine 257049, When Incorporated Into an EPI Regimen Completed
  24. Phase 2 OZ439 PhIIa Study in Plasmodium Falciparum: Extended Observation Completed
  25. Phase 2 Efficacy, Safety and Immunogenicity Study of GSK Biologicals' Candidate Malaria Vaccine (SB257049) Evaluating Schedules With or Without Fractional Doses, Early Dose 4 and Yearly Doses, in Children 5-17 Months of Age Completed
  26. Phase 2 Long-Term Follow-up of Children for a 2-Year Period to Confirm the Safety and Immunogenicity of GSK 257049 Vaccine Completed
  27. Phase 2 Efficacy of RTS,S/AS01 Vaccine Against Episodes of Malaria Due to P. Falciparum Infection in Children. Completed
  28. Phase 2 Safety, Tolerability, Immunogenicity and Protective Efficacy of PfSPZ Vaccine and PfSPZ-CVac in Indonesian Adults Against Naturally-Transmitted Malaria Completed
  29. Phase 2 Evaluation of Reproducibility of a Sporozoite Challenge Model for Plasmodium Vivax in Human Volunteers Completed
  30. Phase 2 A Study to Assess the Safety and Immunogenicity of the Malaria Vaccine, R21, With Matrix-M1 Adjuvant Completed
  31. Phase 2 A Study to Evaluate the Efficacy, Immunogenicity and Safety in a Sporozoite Challenge Model of a Fractional Booster Dose of GSK Biologicals' Candidate Malaria Vaccine Administered to Previously Vaccinated Healthy Malaria-naïve Adults Completed
  32. Phase 2 PfSPZ Vaccine Trial in Malian Children Completed
  33. Phase 2 Sanaria PfSPZ Challenge With Pyrimethamine or Chloroquine Chemoprophylaxis Vaccination (PfSPZ-CVac Approach): A Randomized Double Blind Placebo Controlled Phase I/II Trial to Determine Safety and Protective Efficacy Against Natural Plasmodium Falcipa... Completed
  34. Phase 2 Safety and Efficacy of CIS43LS Anti-malaria mAb in Mali Completed
  35. Phase 2 Safety and Efficacy Study of IV Artesunate to Treat Malaria Completed
  36. Phase 2 Efficacy, Safety, Tolerability and Pharmacokinetics of KAF156 in Adult Patients With Acute, Uncomplicated Plasmodium Falciparum or Vivax Malaria Mono-infection Completed
  37. Phase 2 Weekly Dosing of Malarone ® for Prevention of Malaria Completed
  38. Phase 2 A Study to Find the Minimum Inhibitory Concentration of KAE609 in Adult Male Patients With P. Falciparum Monoinfection Completed
  39. Phase 2 Studies of a Candidate Aminoquinoline Antimalarial (AQ-13) Completed
  40. Phase 2 Aggressive Antipyretics for Fever Reduction in CNS Malaria Completed
  41. Phase 2 L9LS MAb in Malian Adults Completed
  42. Phase 2 A Challenge Study to Assess the Safety, Immunogenicity and Efficacy of a Malaria Vaccine Candidate Completed
  43. Phase 2 Efficacy, Immunogenicity and Safety Study of GSK Biologicals' Candidate Malaria Vaccine Evaluating Different Dose Schedules in a Sporozoite Challenge Model in Healthy Malaria-naïve Adults Completed
  44. Phase 2 Safety of KAE609 in Adults With Uncomplicated Plasmodium Falciparum Malaria. Completed

Showing the 50 most-cited and recently-updated of 123 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Malaria: what the trials found

Several antimalarial regimens have demonstrated high efficacy in clinical and parasitological outcomes. Pyronaridine artesunate showed high crude cure rates at days 21 and 28 13 and a PCR-corrected adequate clinical and parasitological response (ACPR) rate of approximately 97.6% to 98.8% on day 28 14, with nearly 100% success on day 14 14. Additionally, pyronaridine artesunate showed a high PCR-corrected ACPR rate of over 99% on day 28 in another study 9.

Treatment regimens including Artesunate-mefloquine demonstrated high PCR-adjusted malaria cure rates (over 98%) at days 14, 28, and 42 6. Chloroquine was associated with zero instances of severe anemia (Hb <7g/dl) or recurrence of parasitemia within 16 days of follow-up 2.

Vaccine studies for Malaria Vaccine 257049 showed a significant reduction in the rate of first or only clinical episodes of Plasmodium falciparum malaria infection (CPFMI) compared to control groups 21. However, this vaccine was associated with a statistically significant increase in the incidence of clinical malaria meeting specific case definitions 15.

Prophylactic and preventive measures include monthly dihydroartemisinin-piperaquine for pregnant women 7, which showed no significant difference in maternal parasitemia at delivery or placental malaria compared to controls 18. Monthly sulfadoxine-pyrimethamine (SP) during pregnancy was associated with a mean gestational age of approximately 39.5 weeks 11. Lopinavir/Ritonavir showed no significant difference in the prevalence of placental malaria across different measures 17, though it showed a statistically significant difference in the incidence-density of malaria episodes per time at risk 12.

Recent results — preliminary, needs further review

  • [ ] The PfSPZ Vaccine is currently undergoing Phase 2 evaluation 1.

For the clinician treating this condition

  • Pyronaridine artesunate demonstrates high efficacy and rapid clearance of parasites, with nearly 100% PCR-corrected ACPR at day 14 14.
  • Artesunate-mefloquine shows high cure rates (over 98%) through day 42 6.
  • Malaria Vaccine 257049 significantly reduces the rate of first or only clinical episodes of P. falciparum infection, though it is associated with higher incidences of certain clinical malaria case definitions [15, 21].

AI synthesis of 13 cited trials, updated Jun 20, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
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Evaluating Mefloquine Dosage Effects and Tolerability in Artesunate-Mefloquine Regimens for Malaria Meta-analysis shows mefloquine dose impacts malaria recurrence in children
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SP+AQ cuts malaria incidence 54.6% versus SP alone in African children
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SP+AQ cuts malaria incidence 54.6% versus SP alone in African children Adding amodiaquine to sulfadoxine-pyrimethamine reduces malaria in children
This meta-analysis of 32 sites across 13 African countries found that sulfadoxine-pyrimethamine plus amodiaquine (SP+AQ) reduced malaria inc…
Combining two medicines significantly lowers malaria rates in children across Africa compared to using only one drug.
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Schistosomiasis infection increases odds of malaria co-infection by 1.27 in children and adolescents
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This systematic review and meta-analysis of 30 studies involving children and adolescents in Sub-Saharan Africa indicates that schistosomias…
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Pfkelch13 mutations occur in 6% of Plasmodium falciparum isolates across various African regions
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One in six blood donors in Cameroon carries Plasmodium infection, meta-analysis finds
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A systematic review and meta-analysis of 18 studies (~12,500 donations) found a 16.6% pooled prevalence of Plasmodium spp. in Cameroonian bl…
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Clinical and laboratory abnormalities linked to higher mortality in malaria patients with acute kidney injury
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Questions about Malaria

Does a child with schistosomiasis have higher odds of having malaria?

Yes, a child with schistosomiasis has about 1.27 times higher odds of also having malaria, based on a 2026 meta-analysis.

Full answer →
Does having schistosomiasis increase the risk of malaria in children?

Yes, having schistosomiasis is linked to a higher chance of malaria in children, with about 1.27 times higher odds of co-infection.

Full answer →
Can virus-like particles be engineered to protect against malaria?

Yes, virus-like particles (VLPs) can be engineered to protect against malaria, with studies showing they can display malaria antigens and induce protective immune responses in animals.

Full answer →

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