Systematic review suggests partial glossectomy with speech therapy improves speech retention and reduces costs for oral cancer patients.

Glossectomy is performed to treat and extract the malignant lesions of the tongue. The purpose of the study was to explore the effects of glossectomy on speech and introduction to speech therapy. It also focused on the mental health of patients with oral cancer during and after treatment including issues of financial burden, reentering society, and quality of life post treatment. The systematic review was conducted using databases such as PubMed, Scopus, and Web of Science, focusing on studies published between 2001 and 2025. The review included cross-sectional and prospective studies, original research, and review articles. Relevant primary studies were assessed based on predetermined inclusion criteria to ensure alignment with the research objectives. The reviewed literature showed high-quality studies with minimal bias. Findings indicated that oral cancer patients undergoing partial glossectomy have a better chance for speech retention, facilitated by speech therapy methods. Regarding cost, early-stage intervention with single-modality treatments were less costly than late-stage, multi-modality treatments. Additionally, concerns regarding appearance and reintegration into society were prevalent among participants, with many facing challenges in resuming daily activities post-treatment. Mental health outcomes revealed that more than 40% of patients experienced worsened depression during treatment. Partial glossectomy is preferred due to its potential for smoother integration to society and improved speech recovery with therapy. Mental health support remains a key focus as oral cancer patients navigate through the ongoing challenges.