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Home › Conditions › Oral Cancer

Oral Cancer

7 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Oral Cancer

51 trials tracked for Oral Cancer: 6 in phase 3 or 4 and 3 with published results. The most-cited published study has 151 citations.

51Trials tracked
6Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 3 6 Phase 2 36 Phase 1 2 Other / NA 7
  1. Phase 3 Erlotinib Prevention of Oral Cancer (EPOC) Completed · 151 cited
  2. Phase 3 Radiation Therapy With Durvalumab or Cetuximab in Treating Patients With Locoregionally Advanced Head and Neck Cancer Who Cannot Take Cisplatin Completed · 54 cited
  3. Phase 3 Efficacy and Safety Study of Leukocyte Interleukin,Injection (LI) to Treat Cancer of the Oral Cavity Completed · 4 cited
  4. Phase 3 Docetaxel Based Chemotherapy Plus or Minus Induction Chemotherapy to Decrease Events in Head and Neck Cancer (DeCIDE) Completed
  5. Phase 3 DOM-INNATE: Study of SGX942 for the Treatment of Oral Mucositis in Patients With Concomitant Chemoradiation Therapy for Head and Neck Cancer Completed
  6. Phase 3 GM-CSF Mouthwash for Preventing and Treating Mucositis in Patients Undergoing Radiation Therapy for Head and Neck Cancer Completed
Show 44 more trials
  1. Phase 2 GSK1120212 in Surgically Resectable Oral Cavity Squamous Cell Cancer Completed
  2. Phase 2 Dasatinib in Treating Patients With Recurrent or Metastatic Head and Neck Cancer Completed
  3. Phase 2 Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer Completed
  4. Phase 2 Vandetanib in Preventing Head and Neck Cancer in Patients With Precancerous Head and Neck Lesions Completed
  5. Phase 2 Vorinostat in Treating Patients With Locally Advanced, Recurrent, or Metastatic Adenoid Cystic Carcinoma Completed
  6. Phase 2 Capecitabine and Lapatinib Ditosylate in Treating Patients With Squamous Cell Cancer of the Head and Neck Completed
  7. Phase 2 F-18 Fluorothymidine PET Imaging for Early Evaluation of Response to Therapy in Head & Neck Cancer Patients Completed
  8. Phase 2 Cisplatin and Radiation Therapy With or Without Erlotinib Hydrochloride in Treating Patients With Stage III or Stage IV Head and Neck Cancer Completed
  9. Phase 2 Sunitinib in Treating Patients With Recurrent and/or Metastatic Head and Neck Cancer Completed
  10. Phase 2 Tadalafil and Pembrolizumab in Recurrent or Metastatic Head and Neck Cancer Completed
  11. Phase 2 Bowman-Birk Inhibitor Concentrate in Preventing Cancer in Patients With Oral Leukoplakia Completed
  12. Phase 2 Temsirolimus With or Without Cetuximab in Patients With Recurrent and/or Metastatic Head and Neck Cancer Who Did Not Respond to Previous Therapy Completed
  13. Phase 2 IRX-2 Regimen in Patients With Newly Diagnosed Stage II, III, or IVA Squamous Cell Carcinoma of the Oral Cavity Completed
  14. Phase 2 Pembrolizumab in Treating Patients With High Risk Oral Intraepithelial Neoplasia Completed
  15. Phase 2 Sodium Thiosulfate in Preventing Ototoxicity for Squamous Cell Cancer Patients Undergoing Chemoradiation With Cisplatin Completed
  16. Phase 2 Nivolumab, Carboplatin, and Paclitaxel in Treating Patients With Stage III-IV Head and Neck Squamous Cell Carcinoma That Can Be Removed by Surgery Completed
  17. Phase 2 Clinical Evaluation of Bioadhesive Gels for Oral Cancer Chemoprevention Completed
  18. Phase 2 Akt Inhibitor MK2206 in Treating Patients With Progressive, Recurrent, or Metastatic Adenoid Cyst Carcinoma Completed
  19. Phase 2 Rapamycin Therapy in Head and Neck Squamous Cell Carcinoma Completed
  20. Phase 2 Depsipeptide in Unresectable Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck Completed
  21. Phase 2 Phase II Randomized Trial of the Combination of Cetuximab and Sorafenib or Single Agent Cetuximab Completed
  22. Phase 2 Ficlatuzumab w/wo Cetuximab in Patients w/Cetuximab-Resistant, Recurrent or Metastatic Head/Neck Squamous Cell Carcinoma Completed
  23. Phase 2 Bortezomib With or Without Irinotecan in Treating Patients With Locally Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck Completed
  24. Phase 2 Saracatinib in Treating Patients With Recurrent or Metastatic Head and Neck Cancer Completed
  25. Phase 2 Soy Isoflavones in Preventing Head and Neck Cancer Recurrence in Patients With Stage I-IV Head and Neck Cancer Undergoing Surgery Completed
  26. Phase 2 Reduced-Dose Intensity-Modulated Radiation Therapy With or Without Cisplatin in Treating Patients With Advanced Oropharyngeal Cancer Completed
  27. Phase 2 Combination Chemotherapy With or Without Erlotinib Hydrochloride in Treating Patients With Metastatic or Recurrent Squamous Cell Carcinoma of the Head and Neck Completed
  28. Phase 2 Cetuximab & Nivolumab in Patients With Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma Completed
  29. Phase 2 Vitamin D Plus Celecoxib Therapy to Stimulate Intratumoral Immune Reactivity Completed
  30. Phase 2 PI3K Inhibitor BKM120 and Cetuximab in Treating Patients With Recurrent or Metastatic Head and Neck Cancer Completed
  31. Phase 2 SB-715992 in Treating Patients With Recurrent or Metastatic Head and Neck Cancer Completed
  32. Phase 2 18F-FPPRGD2 PET/CT or PET/MRI in Predicting Early Response in Patients With Cancer Receiving Anti-Angiogenesis Therapy Completed
  33. Phase 2 Acetylcysteine Rinse in Reducing Saliva Thickness and Mucositis in Patients With Head and Neck Cancer Undergoing Radiation Therapy Completed
  34. Phase 2 Fluorouracil, Hydroxyurea, Cetuximab and Twice-daily Intensity Radiation Therapy for Advanced Head and Neck Cancer Completed
  35. Phase 2 Low-cost Enabling Technology for Image-guided Photodynamic Therapy (PDT) of Oral Cancer Cancer. Completed
  36. Phase 2 Lapatinib in Treating Patients With Recurrent and/or Metastatic Adenoid Cystic Cancer or Other Salivary Gland Cancers Completed
  37. Phase 1 Inhibition of Oral Tumorigenesis by Antitumor B Completed
  38. Phase 1 Pharmacokinetic (PK) Analysis of Antitumor B in Patients With Oral Cancer Completed
  39. N/A Oral Care Protocol for the Management of Chemotherapy and Radiation Therapy-Induced Oral Mucositis Completed
  40. N/A Oral Pathology Asynchronous Telementoring Pilot Study Completed
  41. N/A Low-Cost, Portable Flexible Nasopharyngoscope in Head & Neck Cancers in Low Resource Settings - Optimization Phase Completed
  42. N/A Evaluations of Alcohol Warning Labels Completed
  43. N/A Prevention of Oral DNA Damage by Black Raspberries Completed
  44. N/A Prepare to Care, A Supported Self-Management Intervention for Head and Neck Cancer CaregiversHead and Neck Cancer Completed

Showing the 50 most-cited and recently-updated of 51 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Berberine exhibits antimicrobial and anti-inflammatory effects for managing various oral mucosal and dental conditions
Drug Pipeline Sys. Review
Berberine exhibits antimicrobial and anti-inflammatory effects for managing various oral mucosal and dental conditions Berberine Shows Potential for Treating Various Oral Health Conditions
This systematic review synthesizes the pharmacological properties of berberine in treating oral diseases including periodontitis, caries, an…
A review of berberine suggests it may help manage oral diseases like periodontitis and dental caries through its anti-inflammatory and antio…
Frontiers Jul 25, 2026
Hyperspectral imaging shows strong diagnostic performance for oral cancer detection in scoping review
Oncology Sys. Review
Hyperspectral imaging shows strong diagnostic performance for oral cancer detection in scoping review Hyperspectral imaging shows promise for detecting oral cancer
This scoping review of 15 studies found that hyperspectral imaging (HSI) demonstrates strong diagnostic performance for detecting and charac…
A new review finds hyperspectral imaging can spot oral cancer with high accuracy, offering a non-contact alternative for margin assessment.
Frontiers Jul 9, 2026
Epigallocatechin-3-gallate shows positive therapeutic effects on various digestive system diseases in animal models
Oncology Meta-analysis
Epigallocatechin-3-gallate shows positive therapeutic effects on various digestive system diseases in animal models Green tea compound shows potential for several digestive diseases
This meta-analysis of 63 preclinical studies involving 738 animals indicates that Epigallocatechin-3-gallate (EGCG) has a positive therapeut…
A review of animal studies suggests a green tea compound could help treat various cancers and digestive conditions.
Frontiers Jun 11, 2026
Advanced experimental models and computational tools provide dynamic frameworks for understanding oral disease progression
Neurology Sys. Review
Advanced experimental models and computational tools provide dynamic frameworks for understanding oral disease progression New Research Tools Help Map Complex Oral Diseases
This mini-review examines the integration of advanced experimental models, such as organ-on-chip systems and patient-derived organoids, with…
Advanced modeling and AI tools are helping researchers better understand the molecular causes behind conditions like gum disease and oral ca…
Frontiers Jun 9, 2026
Personalized swallowing rehab improves outcomes after oral cancer surgery
Geriatrics & Aging RCT
Personalized swallowing rehab improves outcomes after oral cancer surgery New Swallowing Therapy Helps Oral Cancer Patients Eat and Speak More Easily
This randomized controlled trial in 300 patients with oral squamous cell carcinoma found that a personalized swallowing rehabilitation progr…
Personalized swallowing therapy helps oral cancer patients recover faster, eat more naturally, and avoid dangerous complications like pneumo…
Frontiers Apr 23, 2026
Systematic review finds serum biomarkers show variable diagnostic accuracy for oral cancer detection
Oncology Meta-analysis
Systematic review finds serum biomarkers show variable diagnostic accuracy for oral cancer detection Blood Tests Could Spot Oral Cancer Sooner
A systematic review and meta-analysis of 3,309 subjects (2,069 with oral squamous cell carcinoma, 1,240 controls) examined multiple serum bi…
New blood tests using specific proteins could detect oral cancer before a visible lump forms, potentially saving lives through earlier diagn…
Apr 11, 2026
Oral and IV metronidazole show similar tissue concentrations in oral cancer flap reconstruction
ENT (Otolaryngology) RCT
Oral and IV metronidazole show similar tissue concentrations in oral cancer flap reconstruction Oral and IV metronidazole show similar tissue levels in small oral cancer surgery study
A randomized trial in 18 patients undergoing FAMM flap reconstruction after oral cancer surgery found no significant difference in tissue AU…
Oral and IV metronidazole reach the same tissue levels in oral cancer surgery, suggesting patients might take the antibiotic by mouth instea…
Apr 8, 2026

Questions about Oral Cancer

Are serum biomarkers accurate enough to detect Oral Cancer early?

Serum biomarkers show promise but are not yet accurate enough alone for early oral cancer detection; combining multiple biomarkers improves accuracy.

Full answer →
Can personalized swallowing rehab help after surgery for Oral Cancer?

Yes, personalized swallowing rehab significantly improves swallowing ability, reduces feeding tube dependence, and shortens hospital stay after oral cancer surgery.

Full answer →