Source control and antibiotic stewardship remain cornerstones of sepsis management

This narrative review summarizes current perspectives on sepsis management, focusing on foundational strategies rather than novel interventions. The authors underscore that timely source control and judicious antibiotic use remain critical to improving outcomes in septic patients. They also advise against administering live probiotics to high-risk sepsis patients due to safety concerns.

The review draws on existing literature but does not present pooled effect sizes or systematic comparisons. It reflects expert opinion and clinical consensus rather than quantitative synthesis. The authors do not report specific study populations, sample sizes, or outcomes, limiting the ability to assess the strength of evidence behind each recommendation.

Limitations of the review include its narrative design, which may introduce selection bias, and the absence of a systematic search strategy or risk-of-bias assessment. The authors do not discuss specific gaps in the evidence base or conflicting data.

For clinicians, the review reinforces established sepsis management principles: prioritize source control, adhere to antibiotic stewardship, and avoid live probiotics in immunocompromised or critically ill patients. These recommendations align with current guidelines but should be interpreted as expert opinion rather than high-certainty evidence.