Review of ESBL-producing E. coli epidemiology and fluoroquinolone resistance in Mexican community isolates
Photo by Navy Medicine / Unsplash
Key Takeaway
Consider local surveillance for ESBL and fluoroquinolone resistance in community E. coli isolates.
This retrospective cross-sectional study examines the epidemiology and predictive factors associated with ESBL-producing E. coli and its concomitant fluoroquinolone resistance among community-acquired clinical isolates in Mexico. The analysis included a sample size of 244 isolates. The study is categorized as a review of observational data rather than a randomized trial.
Key findings indicate that 165 of 244 isolates were ESBL producing, representing 68% of the total. Resistance among these ESBL-producing isolates was observed at 30% for levofloxacin and 35% for ciprofloxacin. The highest frequency of ESBL production occurred in the 20 to 39 age group. Additionally, 73% of ESBL-positive isolates were obtained from women, though the association was non-significant with an OR of 1.29 and a 95% CI of 0.72 to 2.31. Urine samples showed the highest concentration of ESBL-positive isolates.
The authors underscore the need to strengthen antimicrobial use management and local surveillance strategies. Safety data, including adverse events and tolerability, were not reported. The study does not establish causality, and limitations regarding the observational nature of the data are inherent to the design.
Practice relevance is directed toward monitoring resistance patterns in community settings. Clinicians should interpret these resistance rates as indicators for empirical therapy choices in specific demographic groups.
More on Urinary Tract Infections
Molecular epidemiology study of rifampicin-resistant TB in Vietnam shows high resistance to other drugs
Vietnam’s TB Crisis Hides a Dangerous Pattern
This molecular epidemiology study analyzed 252 rifampicin-resistant TB isolates from Vietnam using whole genome sequencing. It found high co…
A hidden pattern in Vietnam’s tuberculosis cases reveals most drug-resistant strains also resist other key medicines, changing how doctors m…
Meta-analysis of antimicrobial resistance prevalence in Tanzanian hospital pathogens
Common Antibiotics Are Failing in Tanzania, New Data Reveals
This systematic review and meta-analysis synthesizes data from 28 studies on antimicrobial resistance in clinically relevant pathogens withi…
This research shows that common antibiotics are losing their power in Tanzania, urging a critical update to how infections are treated.
Retrospective cohort study assesses Acinetobacter baumannii prevalence and resistance in ventilator-associated infections.
ICU Infection Risk Skyrockets Without Local Drug Data
This retrospective observational cohort analyzed 3,540 non-duplicate clinical isolates from a tertiary-care ICU in South India. The study ev…
ICU patients with breathing tubes face higher infection risks when doctors lack fresh local data on which antibiotics actually work against …
Machine learning models predict ciprofloxacin resistance in Shigella isolates from Ontario.
New Test Predicts Drug Failure Before It Starts
This primary research article evaluates machine learning models using k-mer features from whole-genome sequencing data to predict ciprofloxa…
A smart new computer program can tell doctors if a specific bug will ignore a common antibiotic, helping them pick a drug that actually work…
View Original Abstract ↓
Urinary tract infections (UTIs) are among the most common infectious diseases worldwide, with Escherichia coli being the predominant uropathogen. The increasing prevalence of extended-spectrum beta-lactamase (ESBL)producing strains and their association with fluoroquinolone resistance pose a significant challenge to empirical therapy, particularly in community settings. The aim of this study was to determine the epidemiology and predictive factors associated with ESBL-producing E. coli and its concomitant fluoroquinolone resistance in community acquired clinical isolates. A retrospective cross-sectional study was conducted analyzing 244 clinical E. coli isolates. Demographic and microbiological data were collected, including age, sex, sample type, and antibiotic susceptibility. Associations between variables and ESBL production were assessed using Pearson's chi squared test, and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Of the isolates, 165 (68%) were ESBL producing. A significant association was observed between age group and ESBL production (p < 0.001), with the highest frequency in the 20 to 39 age group. Most ESBL positive isolates were obtained from women (73%), although odds ratio (OR) analysis suggested a non-significant trend toward a higher probability in men (OR = 1.29; 95% CI: 0.72 to 2.31). High rates of fluoroquinolone resistance were identified among the ESBL producing isolates, with 30% resistance to levofloxacin and 35% to ciprofloxacin (p < 0.001). Urine samples showed the highest concentration of ESBL positive isolates, with a significant association between sample type and resistance (p < 0.001). The high prevalence of ESBL producing E. coli and its concomitant resistance to fluoroquinolones highlight a critical challenge for the empirical treatment of urinary tract infections in Mexico, underscoring the need to strengthen antimicrobial use management and local surveillance strategies.
Metformin, fluvoxamine, or ivermectin for non-hospitalized COVID-19 adults in a Phase 3 trial
Metformin Cuts Long Covid Risk by 40%
Related in Infectious Disease
Observational study assesses MiniDock MTB diagnostic accuracy against Xpert in Indonesian TB patients
New TB test shows promise in Indonesia trial
This observational study evaluated the diagnostic accuracy of MiniDock MTB on sputum swabs compared to Xpert MTB/RIF Ultra and liquid cultur…
A new TB test called MiniDock MTB accurately detected TB in adults, but sensitivity dropped in children and low-burden cases.
Phase 1 study traces ainuovirine metabolism and excretion in healthy men
A single dose of oral ainuovirine clears the body within two days in healthy men
This phase 1 open-label study in 6 healthy men examined the pharmacokinetics and mass balance of a single dose of radiolabelled ainuovirine.…
A single dose of oral ainuovirine clears the body within two days in healthy men, with most of the drug leaving unchanged through urine and …
Nirmatrelvir/Ritonavir in Breast Milk: Low Infant Exposure in Lactating Women
Paxlovid levels low in breast milk, early study finds
This Phase 1 open-label study in 8 healthy lactating women found that nirmatrelvir/ritonavir concentrations in breast milk were consistently…
A small study finds that nirmatrelvir/ritonavir (Paxlovid) passes into breast milk at low levels, suggesting minimal infant exposure.
Islatravir and lenacapavir fixed-dose combination shows similar bioavailability to single agents in healthy volunteers
New HIV pill works with or without food in early safety tests
This open-label phase 1 study enrolled 93 people without HIV to assess the oral relative bioavailability and safety of a fixed-dose combinat…
A new HIV pill containing islatravir and lenacapavir showed similar drug levels whether taken with food or on an empty stomach, supporting f…
From Other Specialties
Late-onset rheumatoid arthritis shows higher DAS28 scores and lower remission rates compared to young-onset disease in a meta-analysis.
Meta-analysis compares treatment outcomes in older versus younger rheumatoid arthritis patients
This meta-analysis reviewed data from over 5000 patients with late-onset rheumatoid arthritis (LORA) and young-onset rheumatoid arthritis (Y…
A large review found older patients with rheumatoid arthritis had higher disease activity and lower remission rates on biologics compared to…
Systematic review and meta-analysis of supervised exercise for foot pain in rheumatoid arthritis
Exercise reduces foot pain and improves function in rheumatoid arthritis
This systematic review and meta-analysis evaluated supervised exercise programs in adults with rheumatoid arthritis and foot involvement. Th…
Supervised exercise programs significantly reduce foot pain and improve physical function in adults with rheumatoid arthritis.
Vitamin D supplementation may reduce disease activity in SLE: a systematic review and meta-analysis
Vitamin D supplements may calm lupus activity, study finds
This systematic review and meta-analysis of 847 patients with systemic lupus erythematosus found that vitamin D supplementation significantl…
A new analysis of 847 lupus patients suggests vitamin D supplements may reduce disease activity and improve immune markers.
Therapeutic Touch Reduces Crying and Improves Sleep in Infants With Colic
Therapeutic touch reduces crying in babies with colic
This randomized controlled trial in 96 infants with colic found that therapeutic touch based on Watson's Human Care Theory significantly red…
A new trial shows gentle therapeutic touch helps babies cry less and sleep better when they have infantile colic.