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Oncology
Case report on asciminib plus ponatinib or axitinib in CML relapse with B lymphoblastic blast crisis
New combo drug stops leukemia that fought back against two drugs
This case report describes a single CML patient who relapsed with B lymphoblastic blast crisis harboring a T315I mutation and a novel e6a3 B…
A new three-drug mix stops a tough leukemia that grew stronger after two drugs failed to control it.
medRxiv
Apr 24, 2026
Oncology
RCT
Asciminib superior to IS-TKIs in newly diagnosed CML-CP: MMR 74.1% vs 52.0% at 96 weeks
Could a new leukemia drug work better and cause fewer side effects than current treatments?
In the ASC4FIRST trial, asciminib demonstrated superior efficacy vs investigator-selected TKIs (IS-TKIs) in newly diagnosed CML-CP. At week …
A new leukemia drug helped more patients reach deep disease control with fewer side effects than current standard treatments after two years…
Blood
Mar 30, 2026