Metformin is associated with higher lactate concentrations during exercise in adults with prediabetes and type 2 diabetes
Metformin May Raise Lactate During Exercise
This meta-analysis of 325 participants evaluated the impact of metformin on exercise metabolism and capacity. The analysis found that metfor…
A new analysis suggests metformin may increase lactate levels during exercise, which could affect workout intensity.
GLP-1 agonists show short-term metabolic benefit in PCOS but reproductive effects remain uncertain
Doctors suggest GLP-1 drugs help weight but need careful planning before pregnancy in PCOS
A meta-analysis of GLP-1 receptor agonists in PCOS found relatively robust support for short-term metabolic benefit, but reproductive outcom…
New analysis shows GLP-1 drugs help with weight loss for PCOS patients. However, doctors are unsure if these drugs improve fertility and nee…
Sitagliptin and liraglutide superior for CGM targets in type 2 diabetes
Two diabetes drugs outperform others in long-term glucose control
This randomized trial compared adding sitagliptin, liraglutide, glimepiride, or insulin glargine to metformin in 1,080 participants with typ…
A five-year trial shows sitagliptin and liraglutide offer better glucose stability and safety than glimepiride or insulin glargine for peopl…
Metformin use linked to modest glaucoma risk reduction in diabetic patients
Metformin use linked to lower glaucoma risk in people with diabetes
A large meta-analysis of diabetic patients found metformin use associated with a modest reduction in glaucoma incidence, though evidence cer…
A massive review of over 1.2 million patients suggests metformin might lower the chance of developing glaucoma compared to other diabetes dr…
Metformin shows limited impact on gonadotropin levels in PCOS women
Metformin changes one hormone ratio but leaves others unchanged in PCOS
A meta-analysis of 51 RCTs finds metformin does not alter FSH or LH but significantly increases the LH/FSH ratio in women with PCOS.
Metformin treatment significantly increased the LH to FSH ratio in women with PCOS, while leaving FSH and LH levels alone.
Paternal metformin use during spermatogenesis shows no increased risk for major congenital malformations in over 11 000 children across five countries
New analysis shows fathers taking metformin did not raise birth defect risks for their children
A large meta-analysis involving more than 11 000 live-born children found no association between fathers taking metformin and birth defects.…
A large study of over 11,000 children found no higher risk of birth defects when dads took metformin before conception. This good news appli…
Triple oral therapy with metformin, SGLT-2, and DPP-4 inhibitors lowers HbA1c better than dual regimens in adults with type 2 diabetes
Triple oral diabetes drugs lower blood sugar better than two-drug regimens
A systematic review and meta-analysis of 2,606 adults with type 2 diabetes found that triple oral therapy combining metformin, an SGLT-2 inh…
A large analysis shows that taking three specific oral diabetes medicines together lowers blood sugar more effectively than taking just two …
Systematic review and meta-analysis of metformin for pediatric overweight and obesity shows modest BMI reduction
Metformin shows promise for weight management in children with overweight or obesity
This systematic review and meta-analysis evaluated metformin versus placebo in children with overweight or obesity across 19 original studie…
A meta-analysis of 19 studies suggests metformin may help lower BMI and weight in children with overweight or obesity compared to placebo.
Narrative review suggests precision interventions for preeclampsia phenotypes
At-a-Glance
This narrative review examines prevention strategies for preeclampsia in pregnant women. The authors note that standard low-dose aspirin eff…
Preeclampsia prevention is moving beyond aspirin for everyone, with new research showing that matching treatments to a woman's specific risk…
Guideline on severe pediatric obesity with MC4R variant and puberty management
Two siblings with severe obesity and early puberty found to have genetic changes affecting their growth and health over fourteen years
This guideline, based on a case report of two Chinese siblings with a heterozygous MC4R variant, synthesizes long-term management of monogen…
Two Chinese brothers with severe obesity and early puberty received special treatments for fourteen years. Their puberty slowed down, blood …
Nurse-led care coordination fails to improve medication adherence in high-need patients
Nurse-led care coordination did not improve medication adherence for most common chronic conditions
This pragmatic randomized controlled trial tested nurse-led care coordination versus usual care in high-need, high-cost commercially insured…
A large trial found that nurse-led care coordination did not improve how often people took their diabetes, heart, or thyroid medications com…
Review of NHANES data links metformin use to lower mortality and inflammatory markers in type 2 diabetes
Metformin use linked to lower death risk and better inflammation markers in U.S. adults with diabetes
This review of NHANES 2013-2018 data (2,116 adults) found that metformin use was associated with lower all-cause and cardiovascular mortalit…
New analysis of U.S. adults with diabetes suggests metformin use connects to lower death risk and improved inflammation markers, though more…
All metformin Articles
- Metformin is associated with higher lactate concentrations during exercise in adults with prediabetes and type 2 diabetes
- GLP-1 agonists show short-term metabolic benefit in PCOS but reproductive effects remain uncertain
- Sitagliptin and liraglutide superior for CGM targets in type 2 diabetes
- Metformin use linked to modest glaucoma risk reduction in diabetic patients
- Metformin shows limited impact on gonadotropin levels in PCOS women
- Paternal metformin use during spermatogenesis shows no increased risk for major congenital malformations in over 11 000 children across five countries
- Triple oral therapy with metformin, SGLT-2, and DPP-4 inhibitors lowers HbA1c better than dual regimens in adults with type 2 diabetes
- Systematic review and meta-analysis of metformin for pediatric overweight and obesity shows modest BMI reduction
- Narrative review suggests precision interventions for preeclampsia phenotypes
- Guideline on severe pediatric obesity with MC4R variant and puberty management
- Review of NHANES data links metformin use to lower mortality and inflammatory markers in type 2 diabetes
- Nurse-led care coordination fails to improve medication adherence in high-need patients
- Review of observational data links semaglutide and tirzepatide to survival in breast cancer
- Metformin, fluvoxamine, or ivermectin for non-hospitalized COVID-19 adults in a Phase 3 trial
- Computational model review predicts dual optima for combination therapy in ageing
- Metformin use in Type 2 Diabetes shows inconsistent clinical effects in review
- Semaglutide linked to lower neuropsychiatric event risk vs other diabetes drugs in observational study
- Meta-analysis finds preadmission metformin use associated with reduced mortality in diabetic sepsis patients
- Review summarizes fenofibrate, metformin, and MSC modulation in Primary Sjögren disease management
- Narrative review explores metformin and trimetazidine in cardiovascular conditions
- Bayesian network meta-analysis evaluates antidiabetic medications and dementia risk in 4,382,897 patients
- Mini-review links insulin to worse COVID-19 outcomes in type 2 diabetes patients
- Semaglutide dose linked to lower mortality and cardiovascular risk in patients with baseline CVD
- Orforglipron shows superior HbA1c reduction versus oral semaglutide in adults with type 2 diabetes on metformin
- Meta-analysis finds liraglutide improves menstrual frequency and BMI in overweight women with PCOS
- Systematic review links neutrophil extracellular trap dysregulation to pregnancy complications
- FDA Approves Dapagliflozin and Metformin Hydrochloride Extended-Release Tablets for Type 2 Diabetes and Related Risks
- Oral quadruple therapy reduces HbA more than metformin uptitration in type 2 diabetes on triple therapy
- Phase 4 trial compares pioglitazone versus dapagliflozin add-on in type 2 diabetes
- Offline peer support improves BMI and glucose in type 2 diabetes; hybrid support reduces HbA1c
- Metformin with standard therapy shows no significant survival benefit in gynecologic cancers
- Phase 2 trial tests metformin with neoadjuvant radiochemotherapy for locally advanced rectal cancer