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Home › Medications › linaclotide

linaclotide

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of linaclotide

14 trials tracked of linaclotide: 9 in phase 3 or 4 and 3 with published results. The most-cited published study has 70 citations.

14Trials tracked
9Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 1 Phase 3 8 Phase 2 5
  1. Phase 3 A Trial of Linaclotide 290 μg in Patients With Irritable Bowel Syndrome With Constipation (IBS-C) Completed · 70 cited
  2. Phase 3 Linaclotide Safety and Efficacy in Pediatric Participants, 6 to 17 Years of Age, With Irritable Bowel Syndrome With Constipation (IBS-C) or Functional Constipation (FC) Completed · 31 cited
  3. Phase 3 A Phase 3, International, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Efficacy and Safety Trial of Linaclotide Administered Orally for 12 Weeks to Patients With Irritable Bowel Syndrome With Constipation (IBS-C) Completed · 8 cited
  4. Phase 4 An Open-Label, Long-term Study to Assess the Immunogenicity of LINZESS® (Linaclotide) Administered Orally to Adult Participants With Irritable Bowel Syndrome With Constipation or Chronic Idiopathic Constipation Completed
  5. Phase 3 Trial of Linaclotide in Patients With Chronic Idiopathic Constipation Completed
  6. Phase 3 An Open-label, Long-term Safety Study of Linaclotide in Patients With Chronic Constipation or Irritable Bowel Syndrome With Constipation Completed
Show 8 more trials
  1. Phase 3 An Open-Label, Long-Term Safety Study of Linaclotide in Patients With Chronic Constipation or Irritable Bowel Syndrome With Constipation Completed
  2. Phase 3 A Study to Assess Adverse Events and Change in Symptoms With Linaclotide Versus Placebo in Pediatric Subjects, Ages 2 to 5 Years, With Functional Constipation Completed
  3. Phase 3 Trial of Linaclotide in Patients With Chronic Constipation Completed
  4. Phase 2 Randomized, Double-blind, Dose-range-finding, Phase 2 Study of Linaclotide Administered to Patients With Irritable Bowel Syndrome With Constipation (IBS-C) Completed
  5. Phase 2 Linaclotide Safety and Efficacy in 2 to 5-Year-Old Participants With Functional Constipation Completed
  6. Phase 2 A Study to Assess Adverse Events and Change in Disease Activity in Pediatric Participants (Age 6 Months to <2 Years) With Functional Constipation Who Are Treated With Linaclotide Completed
  7. Phase 2 Dose-range-finding, Phase 2 Trial of Oral Linaclotide Acetate Administered to Patients With Chronic Constipation Completed
  8. Phase 2 Trial of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation (IBS-C) Completed

Showing the 14 most-cited and recently-updated of 14 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Linaclotide combined with polyethylene glycol significantly improves bowel preparation quality in patients with constipation
Gastroenterology Meta-analysis
Linaclotide combined with polyethylene glycol significantly improves bowel preparation quality in patients with constipation Combining two medications improves bowel prep for patients with constipation
This meta-analysis of randomized controlled trials evaluated the impact of linaclotide-PEG versus PEG alone on bowel preparation for patient…
A new combination treatment helps people with constipation get a cleaner colon during preparation for a colonoscopy.
Frontiers Jul 15, 2026
Adding linaclotide to PEG did not improve bowel prep quality in high-risk colonoscopy patients undergoing screening procedures
Gastroenterology RCT
Adding linaclotide to PEG did not improve bowel prep quality in high-risk colonoscopy patients undergoing screening procedures Adding Linaclotide to PEG does not improve bowel preparation for colonoscopy
A randomized trial found that adding linaclotide to polyethylene glycol did not significantly improve adequate bowel preparation rates or ad…
A trial found that adding linaclotide to polyethylene glycol did not improve bowel preparation or adenoma detection compared to placebo plus…
Jun 5, 2026