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Home › Medications › pirtobrutinib

pirtobrutinib

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of pirtobrutinib

11 trials tracked of pirtobrutinib.

11Trials tracked
0Phase 3 & 4
0Recruiting
0With published results
Phase distribution
Phase 1 11
  1. Phase 1 A Drug Drug Interaction (DDI) Study of Pirtobrutinib (LOXO-305) and Different Formulations of Midazolam in Healthy Participants Completed
  2. Phase 1 A Study to Evaluate Pirtobrutinib (LOXO-305) in Healthy Adult Participants Completed
  3. Phase 1 A Study of Effect of Multiple Doses of LOXO-305 on the Pharmacokinetics of Single Oral Doses of CYP1A2, CYP2C9, CYP2C19 Substrates in Healthy Participants Completed
  4. Phase 1 Study of Pirtobrutinib (LOXO-305) in Participants With Impaired Kidney Function and Healthy Participants Completed
  5. Phase 1 A Study of the Effects of Pirtobrutinib (LOXO-305) on Repaglinide (CYP2C8 Substrate) in Healthy Participants Completed
  6. Phase 1 Study of Pirtobrutinib (LOXO-305) in Participants With Impaired Liver Function and Healthy Participants Completed
Show 5 more trials
  1. Phase 1 A Drug Drug Interaction (DDI) Study of Pirtobrutinib (LOXO-305) and Digoxin (P-Glycoprotein Substrate) in Healthy Participants Completed
  2. Phase 1 A Study of Two Different Formulations of Pirtobrutinib (LOXO-305) In Healthy Participants Completed
  3. Phase 1 A Study to Evaluate the Effect of Pirtobrutinib (LOXO-305) on QTc Interval in Healthy Participants Completed
  4. Phase 1 A Study of the Effect of Food on Pirtobrutinib (LOXO-305) in Healthy Participants Completed
  5. Phase 1 A Drug Drug Interaction (DDI) Study of Pirtobrutinib (LY3527727) and Rosuvastatin in Healthy Participants Completed

Showing the 11 most-cited and recently-updated of 11 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Pirtobrutinib Combined with Venetoclax and Rituximab Improves Progression Free Survival
Oncology RCT
Pirtobrutinib Combined with Venetoclax and Rituximab Improves Progression Free Survival Trial shows pirtobrutinib improves survival for chronic lymphocytic leukemia
Adding pirtobrutinib to a venetoclax-rituximab regimen significantly extends progression-free survival in patients with chronic lymphocytic …
A new combination treatment involving pirtobrutinib may help patients with chronic lymphocytic leukemia live longer without their cancer pro…
Aug 9, 2026
Pirtobrutinib shows activity in relapsed and refractory marginal zone lymphoma patients in a Phase 1/2 trial
Oncology Phase I
Pirtobrutinib shows activity in relapsed and refractory marginal zone lymphoma patients in a Phase 1/2 trial Early trial shows pirtobrutinib helped some patients with relapsed marginal zone lymphoma
This Phase 1/2 trial evaluated pirtobrutinib in 36 patients with relapsed and refractory marginal zone lymphoma.
A new drug helped more than half of patients with relapsed lymphoma shrink their tumors, offering hope for those who have run out of other t…
Apr 16, 2026