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Shift work associated with 43% higher odds of chronic kidney disease in meta-analysisShift work linked to higher odds of chronic kidney disease in adults

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Key Takeaway
Consider shift work as a potential risk factor for CKD, but recognize this is observational evidence.

This systematic review and meta-analysis examined the association between shift work and chronic kidney disease (CKD) in adults. The analysis included 12 observational studies, with 6 studies providing data for the meta-analysis. Shift workers (including night or rotating shifts) were compared to non-shift workers, with CKD outcomes defined as reduced estimated glomerular filtration rate, proteinuria, or albuminuria.

The main finding was that shift workers had significantly higher odds of CKD, with a pooled odds ratio of 1.43 (95% CI: 1.06-1.92). The analysis did not report absolute numbers, follow-up duration, or specific safety or tolerability data. The modest heterogeneity and moderate to low risk of bias across studies support the robustness of this association.

Key limitations include varying definitions of CKD outcomes across included studies and the observational nature of the evidence, which precludes causal inference. The authors note these findings support the need for targeted occupational health surveillance and preventive strategies for shift-working populations. However, clinicians should interpret these results cautiously as they represent an association rather than proven causation.

Researchers reviewed 12 existing studies to see if there is a link between working shifts and chronic kidney disease (CKD) in adults. CKD is a condition where the kidneys don't work as well as they should over time. The studies looked at people who worked night shifts or rotating shifts and compared them to people who worked regular daytime hours.

The main finding was that shift workers had higher odds of having CKD. Specifically, the combined data showed shift workers had about 43% higher odds. This means the link was statistically significant, but it's important to remember this comes from observational studies. These types of studies can find associations, but they cannot prove that shift work directly causes kidney disease.

There are a few reasons to be careful with these results. The different studies in the review did not all define kidney disease outcomes in exactly the same way. Also, while the overall quality of the studies was moderate to low risk of bias, other lifestyle factors common among shift workers (like sleep patterns or diet) could play a role. The researchers did not report on specific safety concerns or side effects.

What this means for readers is that there appears to be a connection between shift work and kidney health. This supports the idea that people who work shifts might benefit from more targeted health check-ups. However, because this is an observed link and not proof of cause, more research is needed to understand exactly why this connection exists.

What this means for you:
Observational studies link shift work to higher odds of kidney disease, but more research is needed to understand why.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedApr 2026
View Original Abstract ↓
OBJECTIVES: This systematic review and meta-analysis is aimed to critically evaluate and quantify the association between shift work and chronic kidney disease (CKD). METHODS: We searched PubMed, Embase, and Web of Science through May 2025 for observational studies examining shift work-including night or rotating shifts-and CKD outcomes among adults. Eligible outcomes included reduced estimated glomerular filtration rate (eGFR), proteinuria, or albuminuria. Study quality was assessed using the Newcastle-Ottawa Scale, and meta-analyses were performed where feasible. RESULTS: Twelve studies were included in this systematic review. Most studies defined CKD as eGFR below 60 mL/min/1.73 m or presence of albuminuria, although outcome definitions varied. Meta-analysis of 6 studies found that shift workers had significantly higher odds of CKD (pooled odds ratio: 1.43; 95% CI: 1.06-1.92) compared to non-shift workers. Risk of bias was moderate to low across studies. Heterogeneity was modest, and no significant publication bias was detected. CONCLUSIONS: Shift work is associated with a modestly increased risk of CKD. Circadian disruption and related metabolic disturbances may underlie this relationship. Given the widespread prevalence of shift work and the global burden of CKD, these findings support the need for targeted occupational health surveillance and preventive strategies for shift-working populations.
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