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Mini review of Explainable AI for kidney stone segmentation in resource-constrained settingsExplainable AI tools may help doctors spot kidney stones in low-resource areas

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Key Takeaway
Note that XAI for kidney stone segmentation faces dataset diversity and validation limitations.

This mini review examines the application of Explainable AI techniques, including SHAP, LIME, Grad-CAM, Layer-wise Relevance Propagation, and EigenCAM, within deep learning and hybrid models for kidney stone segmentation. The scope focuses on resource-constrained settings where such technologies aim to improve diagnostic workflows. The authors note that these approaches are intended to enhance clinicians' trust and support clinical decision-making.

The review identifies several key limitations that constrain current implementation. These include a lack of diversity in datasets, an absence of multimodal integration, and a scarcity of real-world validation. Because these gaps exist, the synthesized evidence does not yet support broad clinical adoption without further verification.

The authors conclude that while these AI tools offer potential benefits for early diagnosis, their utility remains theoretical in many contexts. Practice relevance is currently limited to enhancing trust rather than replacing standard diagnostic protocols. Clinicians should await more robust validation before integrating these specific XAI methods into routine care.

A mini review examined eighteen representative studies on using Explainable AI techniques like SHAP and LIME for kidney stone segmentation. These methods integrate with deep learning and hybrid models to help identify stones in medical images. The focus was on resource-constrained settings where advanced imaging tools may be scarce. The review aimed to see if these AI tools could enhance clinician trust and support early diagnosis.

The studies looked at various AI approaches but noted several gaps. There was a lack of diversity in the datasets used, which could limit how well the tools work across different patient groups. Additionally, the research did not include multimodal integration, meaning it did not combine multiple data types for a fuller picture. Real-world validation was also scarce, as most tests occurred in controlled environments rather than busy clinics.

Safety concerns were not reported in the reviewed literature because these are software tools rather than drugs or devices. However, the absence of real-world testing means clinicians should proceed with caution. The main reason to be careful is that the current evidence is limited by data gaps and a lack of practical testing in diverse populations. Readers should view this as a promising but incomplete area of research that requires more study before widespread adoption.

What this means for you:
AI tools may aid kidney stone detection in low-resource areas, but data diversity and real-world testing are currently limited.

Study Details

Study typeSystematic review
EvidenceLevel 1
PublishedMay 2026
View Original Abstract ↓
Kidney stones are one of the most common renal disorders that can produce severe complications if not diagnosed and treated early. Recently, advances in AI have ensured that deep learning and explainable AI enable the automatic segmentation and detection of kidney stones from medical imaging, thus improving diagnostic efficiency and accuracy. For this review, eighteen representative studies using machine learning, deep learning, and hybrid models for kidney stone segmentation were considered, which were published in the period between 2020 and 2025. The XAI techniques being mainly utilized with the discussed models in the study are SHAP, LIME, Grad-CAM, Layer-wise Relevance Propagation, and EigenCAM. Such approaches tend to enhance clinicians’ trust in allowing early diagnosis and supporting clinical decision-making, especially in resource-constrained settings. Regardless of the towering results, this area still suffers due to certain limitations such as lack of diversity in datasets, absence of multimodal integration, and scarcity of real-world validation. All in all, integrating DL with XAI presents a transparent, reliable, and clinically acceptable approach to detecting and segmenting kidney stones.
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