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In-hospital delays before reperfusion correlate with worse outcomes in patients undergoing endovascular thrombectomyTime matters for stroke patients receiving endovascular thrombectomy

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Key Takeaway
Note that in-hospital delays between randomization and reperfusion correlate with higher disability in LVO stroke patients.

This meta-analysis evaluated the impact of timing on outcomes for patients with large vessel occlusion (LVO) strokes presenting within 6 to 24 hours of onset. The study analyzed 505 patients undergoing endovascular thrombectomy (EVT) compared to medical therapy alone, focusing on disability and functional independence as primary and secondary outcomes.

The analysis found no significant association between onset-to-randomization time and either disability (aOR 1.02; 95% CI 0.96-1.08) or functional independence (aOR 1.06; 95% CI 0.95-1.17). However, longer randomization-to-reperfusion times were associated with worse outcomes in the EVT group, specifically showing higher disability (aOR 0.58; 95% CI 0.37-0.91) and lower functional independence (aOR 0.51; 95% CI 0.28-0.96).

In the control group, outcomes worsened with increasing time from onset to randomization for both disability (aOR 0.93; 95% CI 0.87-1.00) and functional independence (aOR 0.84; 95% CI 0.73-0.97). The authors note that while EVT remains beneficial in the 6-24 hour window with advanced imaging, in-hospital delays are associated with poorer outcomes. These findings suggest that minimizing time to reperfusion is critical for maximizing the efficacy of endovascular interventions.

How this fits prior evidence

This meta-analysis addresses a gap regarding the impact of specific timing metrics on stroke outcomes. It extends existing knowledge by identifying that while onset-to-randomization may not be a primary driver of outcome in the 6-24 hour window, internal delays (randomization-to-reperfusion) are significantly associated with worse disability and lower functional independence. This finding complements other evidence regarding endovascular thrombectomy for ischemic stroke.

When a person suffers a major stroke involving a large blood vessel, time is everything. Doctors often use a procedure called endovascular thrombectomy (EVT) to remove the blockage. New data looking at 505 patients shows that while the treatment remains effective for people arriving within 6 to 24 hours of their symptoms starting, internal hospital timing is critical.

While the initial window of arrival matters less than previously thought because of advanced imaging, delays inside the hospital can hurt a patient's chances. Specifically, longer times between being admitted and actually receiving the procedure were linked to higher levels of disability and lower rates of functional independence.

This means that while patients have a decent window for treatment after their symptoms begin, moving quickly once they are in the hospital is vital. The study highlights that speed during the actual medical process directly impacts how well a patient can function three months later.

What this means for you:
While some flexibility exists in arrival time, rapid in-hospital treatment is vital for better stroke recovery.

Common questions

How does the time of arrival affect stroke treatment?

For patients with large vessel occlusion strokes arriving between 6 and 24 hours after symptoms start, the specific minute of arrival did not show a significant link to disability or functional independence. This suggests that advanced imaging helps identify suitable candidates even later in the window.

Why is hospital speed so important for recovery?

Even if a patient arrives within the 6-to-24-hour window, delays between being admitted and receiving the procedure (randomization-to-reperfusion) are linked to worse outcomes. Longer times in this phase were associated with higher disability and lower functional independence.

What is functional independence?

Functional independence refers to a patient's ability to perform daily activities without significant help. The study found that longer delays during the hospital treatment process led to lower rates of functional independence for patients receiving endovascular thrombectomy.

Study Details

Study typeMeta analysis
Sample sizen = 505
EvidenceLevel 1
Follow-up840.0 mo
PublishedAug 2026
View Original Abstract ↓
BACKGROUND AND OBJECTIVES: Time to endovascular thrombectomy (EVT) is a critical determinant of outcomes for large vessel occlusion (LVO) strokes presenting within 6 hours of onset. Its impact in the extended (6-24-hour) window remains uncertain. We aimed to evaluate the association between treatment times and outcomes in this window. METHODS: Individual patient-level data from 6 randomized trials enrolling patients in the extended window were pooled. The primary outcome was degree of disability at 90 days (modified Rankin Scale [mRS] 0-6). Secondary outcomes included functional independence (mRS 0-2), mortality, and symptomatic intracranial hemorrhage. RESULTS: Among 505 participants (median age 70 years; baseline NIH Stroke Scale 16; 51.3% female; advanced imaging selection 86.5%), 266 (52.7%) received EVT and 239 (47.3%) medical therapy alone. In EVT-treated patients, longer onset-to-randomization times were not associated with differences in disability (adjusted odds ratio [aOR] per 60 minutes 1.02; 95% CI 0.96-1.08; = 0.53) or functional independence (aOR 1.06; 95% CI 0.95-1.17; = 0.28). Conversely, control patients exhibited worse outcomes with increasing onset-to-randomization times (aOR for disability 0.93; 95% CI 0.87-1.00; = 0.041; functional independence 0.84; 95% CI 0.73-0.97; = 0.019), resulting in greater treatment benefit at later times (-interaction = 0.033 and 0.003, respectively). No association was observed between onset-to-puncture or onset-to-reperfusion and outcomes in EVT patients. However, longer randomization-to-reperfusion times correlated with worse disability (aOR 0.58; 95% CI 0.37-0.91; = 0.018) and lower functional independence (aOR 0.51; 95% CI 0.28-0.96; = 0.038). DISCUSSION: This study demonstrates that the benefit of EVT is consistently preserved across the extended (6-24-hour) time window when patients are selected using advanced imaging criteria. In this highly selected population, enriched with slow progressors, the apparent increase in treatment effect with longer onset-to-presentation times reflects the validity of physiologic selection rather than true time insensitivity. However, this observation should not diminish the critical importance of time: imaging-based selection effectively resets the treatment clock, masking the harmful impact of prehospital delays. Notably, longer in-hospital delays were strongly associated with worse outcomes, reinforcing that "time is brain," even in extended-window cohorts.
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