Mode
Text Size
Log in / Sign up

Telehealth CBT improves quality of life in veterans with Parkinson's disease and comorbid depressionTelehealth therapy improved quality of life for veterans with Parkinson's and depression

AI-generated summary of the cited source, checked by automated accuracy review. How we work

Key Takeaway
Consider telehealth CBT for depression to improve quality of life in veterans with Parkinson's disease.

A randomized controlled trial evaluated PD-informed cognitive-behavioral therapy (CBT) delivered via telehealth (10 sessions) versus treatment as usual (routine VA care with monitoring) in 90 veterans with both Parkinson's disease and primary depressive disorders. The primary outcome was health-related quality of life measured with the SF-36.

At end-of-treatment, the CBT group showed significant improvement in both physical quality of life (p = 0.007) and mental quality of life (p = 0.04) compared to the control group, which did not improve. Specific effect sizes and absolute numbers for these primary outcomes were not reported. Mediation analysis indicated that depression mediated the relationship between CBT and improved physical quality of life in both parallel (B = 1.90, 95% CI [0.06, 3.94]) and parallel-serial models (B = 1.35, 95% CI [0.01, 3.13]).

Safety, tolerability, and discontinuation data were not reported in the abstract. The study population was specific to veterans with comorbid conditions, which limits generalizability to other populations. Long-term follow-up beyond the treatment period was not reported.

For practice, the findings support the routine assessment and management of depression as a key component of interdisciplinary Parkinson's disease care. The results suggest that telehealth-delivered, PD-informed CBT may be a viable option for improving quality of life in this specific veteran population, though the lack of detailed safety data and long-term outcomes warrants caution.

Researchers studied whether a special form of talk therapy, delivered by video call, could help veterans who have both Parkinson's disease and depression. The study involved 90 veterans who received either 10 sessions of this Parkinson's-informed cognitive-behavioral therapy (CBT) or continued with their usual VA care. The therapy was designed to address the unique challenges of living with Parkinson's.

At the end of the treatment, veterans who received the telehealth CBT reported better physical and mental quality of life compared to those who received standard care. The researchers also found that the therapy's positive effect on physical quality of life seemed to happen, in part, by helping to reduce symptoms of depression.

It's important to know this study focused specifically on veterans with both conditions, so the results might not apply to everyone with Parkinson's. The abstract did not report on side effects or how well people tolerated the therapy. The study also only measured results right after treatment ended, so we don't know if the benefits lasted. While the results are promising for this group, more research is needed to understand the long-term effects and how it might work for other people.

What this means for you:
A small study found telehealth CBT improved quality of life for veterans with Parkinson's and depression, but longer-term results are unknown.

Study Details

Study typeRct
Sample sizen = 90
EvidenceLevel 2
PublishedApr 2026
View Original Abstract ↓
OBJECTIVES: Parkinson's disease (PD) is associated with significant impairments in health-related quality of life (HRQoL). Little is known about the impact of psychotherapy on HRQoL in PD. This study aimed to assess the effects of virtual cognitive-behavioral therapy on HRQoL among veterans with PD, and to identify possible mediators for change. METHODS: Veterans with both PD and primary depressive disorders (n = 90) were recruited nationwide and randomized to PD-informed cognitive-behavioral therapy (CBT) or treatment as usual (TAU). The 10-session telehealth CBT intervention focused on behavioral activation, cognitive restructuring, and stress management, with strategies for problem-solving PD-related challenges highlighted throughout. The TAU group received routine VA care with clinical monitoring by study staff. HRQoL was measured with the SF-36, which included summary scores for physical and mental quality of life, along with eight health domain subscales. Depression (HAM-D), behavioral activation (BADS), and automatic negative thoughts (ATQ) were assessed as mediators of CBT and HRQoL in parallel and parallel-serial mediation models.n. RESULTS: There were significant group-by-time effects for physical (p = 0.007) and mental quality of life (p = 0.04) such that the CBT group improved in both by end-of-treatment, while the control group did not. Depression mediated the relationship between CBT and physical quality of life in both parallel (B = 1.90, 95% CI [0.06, 3.94]) and parallel-serial (B = 1.35, 95% CI [0.01, 3.13]) models. CONCLUSIONS: Cognitive-behavioral therapy holistically improves both the physical and mental challenges that Parkinson's disease places on everyday life. The routine assessment and management of depression in PD is a key component of evidence-based interdisciplinary care.
Free Newsletter

Clinical research that matters. Delivered to your inbox.

Join thousands of clinicians and researchers. No spam, unsubscribe anytime.