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Narrative review explores fMRI utility in otolaryngology disorders including tinnitus and vestibular migraine.

Narrative review explores fMRI utility in otolaryngology disorders including tinnitus and vestibular…
Photo by Pawel Czerwinski / Unsplash
Key Takeaway
Consider fMRI as a potential tool for elucidating mechanisms in otolaryngology disorders, though evidence remains conceptual.

This narrative review evaluates the role of functional magnetic resonance imaging (fMRI) within the context of otolaryngology–head and neck disorders. The scope of the article encompasses a range of specific conditions, including tinnitus, sudden sensorineural hearing loss, vestibular migraine, and olfactory dysfunction. By aggregating existing qualitative data, the authors aim to provide a comprehensive overview of how neuroimaging techniques are currently conceptualized in this field.

The primary focus of the synthesis is on elucidating the underlying neuropathological mechanisms associated with these disorders. The authors argue that understanding these mechanisms through fMRI could theoretically support precision medicine and facilitate the development of novel therapeutic strategies. However, the review does not report specific pooled effect sizes, numerical outcomes, or comparative data, as these details were not available in the source material.

The authors acknowledge that the evidence remains largely conceptual rather than empirically quantified in this specific review. Limitations include the lack of reported sample sizes, specific settings, or primary outcome data from the underlying studies discussed. Consequently, the review serves primarily to identify potential avenues for future investigation rather than to establish definitive clinical guidelines.

In terms of practice relevance, the authors suggest that fMRI may eventually guide personalized management, but current data are insufficient to mandate its routine use. The review highlights the need for further high-quality studies to determine the true utility of these imaging modalities in standard otolaryngology care.

Study Details

Study typeSystematic review
EvidenceLevel 1
PublishedApr 2026
View Original Abstract ↓
Functional magnetic resonance imaging (fMRI) is a non-invasive tool that detects neural activity via BOLD signals. In otolaryngology–head and neck disorders, such as tinnitus, sudden sensorineural hearing loss, vestibular migraine, and olfactory dysfunction, fMRI reveals disease-specific neural pathophysiology, altered functional connectivity, and compensatory brain reorganization. It aids diagnosis and differential diagnosis by distinguishing abnormal regional activity patterns, predicts individual prognosis through connectivity-based biomarkers, monitors treatment response, and informs development of targeted therapeutics. Additionally, fMRI elucidates central mechanisms underlying sensory deficits and secondary psychological or cognitive disturbances, likely resulting from chronic symptom burden or maladaptive central neuroplasticity. This review summarizes recent advances and highlights fMRI’s clinical relevance in elucidating neuropathological mechanisms, guiding personalized management, supporting precision medicine, and facilitating novel therapeutic strategies in otolaryngology.
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