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Home › Conditions › Tinnitus

Tinnitus

5 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Tinnitus

40 trials tracked for Tinnitus: 6 in phase 3 or 4 and 2 with published results. The most-cited published study has 29 citations.

40Trials tracked
6Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 2 Phase 3 4 Phase 2 6 Other / NA 28
  1. Phase 3 AM-101 in the Treatment of Acute Tinnitus 2 Completed · 29 cited
  2. Phase 4 Nitrous Oxide Treatment for Tinnitus Completed · 11 cited
  3. Phase 4 Treatment of Tinnitus With Migraine Medications Completed
  4. Phase 3 AM-101 in the Treatment of Post-Acute Tinnitus 1 Completed
  5. Phase 3 Evaluation of the CR Neuromodulation Treatment for Tinnitus Completed
  6. Phase 3 A Trial of Magnesium Dependent Tinnitus Completed
Show 34 more trials
  1. Phase 2 Zinc to Treat Tinnitus in the Elderly Completed
  2. Phase 2 Cognitive Behavioral Therapy (CBT) for Tinnitus Completed
  3. Phase 2 Investigation of the NMDA Antagonist Ketamine as a Treatment for Tinnitus Completed
  4. Phase 2 Transcranial Magnetic Stimulation for Tinnitus Completed
  5. Phase 2 rTMS To The Dorsolateral Prefrontal Cortex For Patients With Subjective Idiopathic Tinnitus. A Pilot Study Completed
  6. Phase 2 An Open-Label Study Evaluating Brexanolone in Adults With Tinnitus Completed
  7. N/A A CBT-based Internet Intervention for Adults With Tinnitus in the United Kingdom Completed
  8. N/A Neuro-Music-Therapy for Patients With Chronic Tinnitus - a Controlled Clinical Trial Completed
  9. N/A Evaluation of the Clinical Benefit of the Hearing Aids Tinnitus Feature. Completed
  10. N/A Auditory-somatosensory Stimulation to Alleviate Tinnitus Completed
  11. N/A Effect of rTMS on Resting State Brain Activity in Tinnitus Completed
  12. N/A rTMS Bimodal Treatment For Tinnitus: A Pilot Study Completed
  13. N/A Telephone Tinnitus Education for Patients With Traumatic Brain Injury (TBI) Completed
  14. N/A Network Dysregulation Among Individuals With Comorbid Tinnitus and PTSD Completed
  15. N/A Feasibility and Acceptability of Using Low-Gain Hearing Aids for Bothersome Tinnitus Completed
  16. N/A Neurobiological Similarities of Tinnitus and PTSD Completed
  17. N/A Processing Speed as an Objective Measure of Tinnitus Completed
  18. N/A Reversing Synchronized Brain Circuits With Targeted Auditory-Somatosensory Stimulation to Treat Phantom Percepts Completed
  19. N/A Internet-based Cognitive Behavioral Therapy for Tinnitus Sufferers Completed
  20. N/A Cochlear Promontory Stimulation for Treatment of Tinnitus Completed
  21. N/A Using PET-CT to Target and Validate Low-frequency TMS as Treatment for Tinnitus Completed
  22. N/A CBT-based Internet Intervention for Adults With Tinnitus in the United States Completed
  23. N/A Clinical Trial of Sound-Based Versus Behavioral Therapy for Tinnitus Completed
  24. N/A A Comparison of Three Psychoeducational Group Interventions for Veterans With Tinnitus Completed
  25. N/A Progressive Intervention Program for Tinnitus Management Completed
  26. N/A Resting-State Neural Connectivity in Patients With Subjective Tinnitus Without Bother Completed
  27. N/A Cognitive Speed as an Objective Measure of Tinnitus Completed
  28. N/A Internet-based Cognitive Behavioural Therapy for Spanish Tinnitus Sufferers Completed
  29. N/A Vagus Nerve Stimulation (VNS) Paired With Tones for Tinnitus Completed
  30. N/A Somatosensory Tinnitus Study Completed
  31. N/A Mahana Tinnitus Pilot Completed
  32. N/A Multi-Site Evaluation of Progressive Tinnitus Management Completed
  33. N/A Evaluation of Auditory Mirror-therapy for Tinnitus Completed
  34. N/A Internet-based Versus Face-to-face Clinical Care for Tinnitus Completed

Showing the 40 most-cited and recently-updated of 40 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Review compares LLM and physician responses to otologic questions on Reddit
ENT (Otolaryngology)
Review compares LLM and physician responses to otologic questions on Reddit AI Answers Ear Questions With More Empathy Than Doctors
This review analyzed 49 otology-related questions from Reddit's r/AskDocs, comparing responses from ChatGPT-4o, ClaudeAI, and Google Gemini …
AI tools might offer clearer, kinder answers to common ear problems than busy doctors.
medRxiv Jun 4, 2026
PRKRA gene variants linked to tinnitus and mild cognitive impairment
Genetics & Precision Medicine RCT
PRKRA gene variants linked to tinnitus and mild cognitive impairment Gene Variants Linked to Tinnitus and Memory Problems
This RCT of 294 adults with chronic tinnitus from five European clinics found that 15% of those with mild cognitive impairment had rare loss…
Rare gene variants may connect chronic tinnitus with mild cognitive impairment, a new study suggests.
medRxiv May 20, 2026
Meta-analysis reports ACADVL expression and lipid ratio differences in tinnitus patients compared with healthy controls
Neurology Meta-analysis
Meta-analysis reports ACADVL expression and lipid ratio differences in tinnitus patients compared with healthy controls Tinnitus linked to fatty acid metabolism gene changes
This meta-analysis examined oxidative stress-related genes in patients with tinnitus and healthy controls.
Tinnitus may involve a gene that affects how the body breaks down fats, new analysis suggests.
Frontiers Apr 28, 2026
Narrative review explores fMRI utility in otolaryngology disorders including tinnitus and vestibular migraine
Neurology Sys. Review
Narrative review explores fMRI utility in otolaryngology disorders including tinnitus and vestibular migraine The Brain Scan Changing How Doctors See Hearing and Balance Problems
This narrative review examines the application of functional magnetic resonance imaging (fMRI) in patients with otolaryngology–head and neck…
A new brain scan shows that tinnitus and hearing loss aren't just ear problems, but actually change how the brain works.
Frontiers Apr 18, 2026
Phase 2 trial of ketamine for tinnitus in 42 adults did not report main results
ENT (Otolaryngology) Phase II
Phase 2 trial of ketamine for tinnitus in 42 adults did not report main results Can a single ketamine dose quiet the brain's noise in people with tinnitus?
A phase 2 clinical trial investigated ketamine hydrochloride versus placebo in 42 adults with tinnitus.
A single ketamine dose may quiet brain noise in tinnitus by blocking glutamate receptors and boosting calming GABA chemicals, offering hope …
CT.gov Apr 3, 2026

Questions about Tinnitus

Did the phase 2 ketamine trial find main results for tinnitus?

The phase 2 ketamine trial for tinnitus was completed but has not yet reported its main results.

Full answer →