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Vascular risk factors and diagnostic findings in young stroke patients across sixteen MENA centersYoung Adults Are Having Strokes — And the Causes May Surprise You

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Key Takeaway
Note regional variability and diagnostic limitations when evaluating young stroke patients in the MENA region.

This retrospective cohort study analyzed data from 3,971 young adults admitted with stroke at sixteen centers across nine countries in the Middle East and North Africa region. The investigation focused on vascular risk factors, stroke etiologies, and treatment patterns in this specific demographic.

Hypertension was identified as the most common risk factor across all stroke subtypes. For ischemic stroke and intracerebral hemorrhage, diabetes mellitus and hypertension were noted as risk factors. In subarachnoid hemorrhage cases, smoking and hypertension were associated with the condition. Overall, ischemic stroke represented 63.6% of cases, whereas intracerebral hemorrhage accounted for 19.2%.

Diagnostic evaluation revealed that 67.4% of patients had positive results from CT angiogram or carotid Doppler. Abnormalities on transthoracic or transesophageal echocardiogram were found in 11.2% of patients. Positive antiphospholipid screening tests were observed in 3.5% of the cohort. In ischemic stroke cases, undetermined etiology was present in 22.2% of instances.

Treatment administration varied significantly. Intravenous thrombolysis was administered to 8.5% of patients, while mechanical thrombectomy was performed in 3.7%. Anticoagulation therapy was offered to 20% of patients. Endovascular treatment was performed in 5.2% of cases, and surgical interventions were done in 5.6%. The study utilized multinomial logistic regression to evaluate associations, though causality cannot be inferred from this observational design. Key limitations include limited literature from the region, striking variability in patient profiles and healthcare responses between countries, and persistent diagnostic limitations.

Stroke Is Not Just an Older Person's Problem

Stroke occurs when blood flow to part of the brain is cut off or a blood vessel bursts. Brain cells begin dying within minutes. The faster a person gets treatment, the better the chance of survival and recovery.

Globally, stroke rates in young adults are rising. But most stroke research focuses on older Western populations. That gap in knowledge matters because risk factors, causes, and access to care can look very different depending on where you live.

What This Region Faces Differently

Until now, there was very little coordinated data on young stroke in the MENA region — a large and diverse area spanning from Morocco to Iran, covering more than 600 million people.

Risk factors common in this region, including high rates of hypertension (high blood pressure), diabetes, and smoking, may be starting earlier and going untreated longer. That combination is dangerous. But the details of who gets strokes, why, and what treatment they receive had never been studied at this scale.

A Five-Year Look Across Nine Countries

Researchers gathered data from 16 stroke centers in nine MENA countries, covering a five-year period from 2018 to 2022. All patients were young adults — defined as those presenting with stroke at a young age. In total, 3,971 patients were included. Nearly two-thirds (65.5%) were male.

This was not a simple database review. Researchers applied statistical modeling to understand which risk factors were most strongly tied to specific types of stroke.

Hypertension was the most common risk factor across all stroke types, affecting 38% of patients. Diabetes and high blood pressure together were the top risk factors for ischemic stroke (the most common type, where a clot blocks blood flow) and for intracerebral hemorrhage (bleeding inside the brain).

The most common stroke type was ischemic stroke, making up 63.6% of cases. Nearly one in five strokes (19.2%) involved bleeding in the brain. Subarachnoid hemorrhage — bleeding around the brain — was less common but tended to affect smokers.

This is where the treatment picture becomes deeply concerning.

Only 8.5% of patients received intravenous thrombolysis — the clot-dissolving medication that is considered standard care for ischemic stroke in most of the world. Mechanical thrombectomy (a procedure to physically remove the clot) was performed in just 3.7% of cases. These numbers are well below what guidelines recommend and what wealthier countries typically achieve.

In about 22% of ischemic stroke cases, no clear cause was ever found — classified as "undetermined etiology." This points to significant diagnostic limitations in the region, including inconsistent access to imaging and specialist testing.

Why These Gaps Matter

The underuse of clot-removing treatments is not simply a matter of preference. It reflects a combination of late hospital arrival, limited specialist availability, and diagnostic resource constraints. When treatment is delayed or unavailable, the long-term damage from stroke is greater — meaning more disability and more burden on families and healthcare systems.

This report represents the first regionally coordinated effort to examine young stroke across the MENA region. That alone makes it significant. It identifies both the scale of the problem and the variation between countries — suggesting that a single policy solution will not work everywhere.

If you live in the MENA region and have risk factors like high blood pressure, diabetes, or a smoking habit — even in your 20s or 30s — stroke is a real concern worth discussing with a doctor. The warning signs of stroke (sudden weakness, confusion, trouble speaking, vision loss, severe headache) are the same at any age. Acting fast — calling emergency services immediately — can make the difference between full recovery and permanent disability.

This was a retrospective study, meaning researchers looked back at existing records rather than following patients forward in time. Data quality varied between centers and countries. Some diagnostic tests were not performed consistently across all patients, making it harder to identify causes in every case. The findings reflect hospital-based data and may not capture the full picture of young stroke in the region.

This study lays the groundwork for targeted public health action in the MENA region. Researchers and health authorities now have a clearer picture of which risk factors to prioritize in prevention campaigns, where treatment infrastructure needs strengthening, and which gaps in diagnosis need to be closed. Future work will need to track whether interventions — better hypertension control, faster stroke recognition, wider access to thrombolysis — actually reduce the burden of young stroke in this part of the world.

Study Details

Study typeCohort
EvidenceLevel 3
PublishedApr 2026
View Original Abstract ↓
BackgroundStroke at a young age is on the rise globally. The diverse range of underlying etiologies and risk factors for stroke in young adults make it challenging. There are very limited papers in this regard from our Middle East and North Africa (MENA) region.ObjectivesIdentifying risk factors, etiologies and treatment offered to young stroke patients in the MENA region.MethodA five-year multicenter retrospective study across nine MENA countries (2018–2022) was conducted. Multinomial logistic regression was applied to evaluate associations between vascular risk factors and stroke subtypes (adjusted for age, sex, and country).Results16 centers participated including 3,971 patients, 65.5% were male. Hypertension (HTN) was the most common risk factor among all stroke subtypes (38%). Diabetes mellitus (DM) and HTN, were the most frequent risk factors for ischemic stroke (IS) and Intracerebral hemorrhage (ICH). Smoking and HTN were common in subarachnoid hemorrhage (SAH). All patients had either Cerebral Computed topography (CT) angiogram or Carotid Doppler, 32.6% of 67.4% showed positive results. A total of 2,441 (61.9%) patients had Transthoracic Echocardiogram (TTE) and/or Transesophageal Echocardiogram (TEE). 11.2% of the patients showed abnormalities. The antiphospholipid screening tests were done in 31.4% of the patients and were positive only in 3.5%. IS was the most common stroke subtype 63.6%, followed by (ICH) 19.2%. Undetermined etiology (UDE) was the most common underlying etiology of IS in 22.2%. Intravenous thrombolysis therapy (IVT) was given in 8.5% of patients. Mechanical thrombectomy (MT) was performed in 3.7%. Anticoagulation therapy was offered in 20% of patients. Endovascular treatment (EVT) was performed in 5.2% of patients. Surgical intervention including clipping or hemicortectomy or hematoma evacuation was done in 5.6% of patients.ConclusionThis study offers the first regionally coordinated effort to examine the risk factors, and etiologies of stroke in young adults across the (MENA) region. The data clearly reflects not only the high burden of disease but also striking variability in patient profiles and healthcare responses between countries. Emerging non-traditional risk factors, and persistent diagnostic limitations, point to the complexity of tackling stroke in the young. Yet, in this complexity lies opportunity.
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