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Resting-state fMRI shows brain activity differences in women with functional constipation and stress urinary incontinenceDoes stress incontinence and constipation change how your brain works?

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Key Takeaway
Note brain activity differences in FCon-SUI, but interpret cautiously as observational.

This cohort study included 34 female patients with functional constipation and stress urinary incontinence (FCon-SUI), 24 with functional constipation without SUI (FCon-NSUI), and 29 healthy controls. It used resting-state functional magnetic resonance imaging (fMRI) to compare brain activity, measured by amplitude of low-frequency fluctuations (ALFF) and functional connectivity, with FCon-NSUI and healthy controls as comparators. The primary outcomes were ALFF and functional connectivity, with secondary outcomes assessing correlations between brain functional irregularities and clinical symptoms.

Main results showed that ALFF was elevated in the right supplementary motor area (SMA) and right middle frontal gyrus (MFG), and reduced in the left inferior temporal gyrus (ITG) in FCon-SUI patients relative to FCon-NSUI patients. Additionally, right SMA ALFF was positively correlated with KESS scores, indicating a link between brain activity and constipation severity. Exact numbers, effect sizes, and p-values or confidence intervals were not reported for these outcomes.

Safety and tolerability data were not reported in the input. A key limitation is that no prior research has investigated abnormalities in neural regulation mechanisms for patients with comorbid functional constipation and stress urinary incontinence, highlighting the preliminary nature of these findings. The study's practice relevance is to provide valuable insights for monitoring brain changes in FCon-SUI patients and identifying potential therapeutic targets, but it does not establish causality or immediate clinical applications.

For many women, dealing with both functional constipation and stress urinary incontinence is a daily struggle that affects their confidence and comfort. A new look at their brains reveals something surprising: the way their brains process signals is different from women who have only incontinence or no issues at all. Researchers used a special scan called resting-state fMRI to see how different parts of the brain talk to each other when a person is just sitting quietly.

The study looked at 34 women with both conditions, 24 with only incontinence, and 29 healthy women. It found that activity in the right supplementary motor area and right middle frontal gyrus was higher in women with both problems. At the same time, activity in the left inferior temporal gyrus was lower. These brain areas help control movement and process visual information.

The researchers also found that higher activity in the right supplementary motor area matched up with worse scores on a test measuring constipation severity. This suggests a link between brain function and how severe the constipation feels. However, this is the first time anyone has looked at these specific brain patterns in women with both conditions. We do not know if these brain changes cause the symptoms or if the symptoms change the brain. More research is needed to understand exactly what this means for treatment.

What this means for you:
Brain scans show unique activity patterns in women with both constipation and incontinence, offering new clues for future care.

Study Details

Study typeCohort
EvidenceLevel 3
PublishedApr 2026
View Original Abstract ↓
BackgroundNo prior research has investigated whether abnormalities exist in the neural regulation mechanisms of patients with comorbid Functional Constipation (FCon) and Stress Urinary Incontinence (SUI). This study employed neuroimaging to examine differences in brain activity and functional connectivity between female FCon patients with and without SUI.Materials and methodsResting-state fMRI data were prospectively obtained from 34 female patients diagnosed with FCon comorbid with SUI (FCon-SUI), 24 female patients with FC without SUI (FCon-NSUI), and 29 Healthy Controls (HC). The study compared the Amplitude of Low-Frequency Fluctuation (ALFF) among the three groups to identify regions manifesting abnormal local spontaneous neural activity. Regions demonstrating significant ALFF variances were subsequently utilized as seeds for seed-based functional connectivity (FC) analysis. Additionally, correlations between brain functional irregularities and clinical symptoms were examined.ResultsFCon-SUI and FCon-NSUI patients exhibited aberrant ALFF and FC values across various brain regions. Specifically, the FCon-SUI cohort demonstrated elevated ALFF in the right supplementary motor area (SMA) and the right middle frontal gyrus (MFG), as well as reduced ALFF in the left inferior temporal gyrus (ITG) relative to the FCon-NSUI group. In FCon-SUI, right SMA ALFF was positively correlated with KESS scores.ConclusionOur findings highlight the unique neural activity characteristics of FCon-SUI, and provide valuable insights for monitoring brain changes in FCon-SUI patients and identifying potential therapeutic targets.
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